Abstract: An (SOA) system includes a tunable VCSEL laser with one or more active regions having quantum wells and barriers. The one or more active regions are surrounded by one or more p-n junctions. The one or more active regions can include a selected shape structure, one or more tunnel junctions (TJ), one or more apertures provided with the selected shape structure, one or more buried tunnel junctions (BTJ) or oxide confine apertured, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process, the VCSEL having an HCG grading. At least one of an ASIC and driver controller coupled to the VCSEL laser, the ASIC monitoring an output of a light pulse over wavelength.

Abstract: Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

Abstract: An (SOA) system includes a tunable VCSEL laser with one or more active regions having quantum wells and barriers. The one or more active regions are surrounded by one or more p-n junctions. The one or more active regions can include a selected shape structure, one or more tunnel junctions (TJ), one or more apertures provided with the selected shape structure, one or more buried tunnel junctions (BTJ) or oxide confine apertured, additional TJ's, planar structures and or additional BTJ's created during a regrowth process that is independent of a first growth process, the VCSEL having an HCG grading. At least one of an ASIC and driver controller coupled to the VCSEL laser, the ASIC monitoring an output of a light pulse over wavelength.

Abstract: A water splashing toy includes an outer shell having an inner cavity and a plurality of water passages communicated to the inner cavity, and an inner water retaining bladder disposed in the inner cavity of the outer shell. The water splashing toy is easy and convenient for quick water filling, and the toy bounces well on a user body and does not explode, so that the user will not get hurt or feel pain when playing the water splashing toy.

Abstract: Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

Abstract: A scalable Ising machine system comprises a plurality of chips, each chip comprising a plurality of N nodes, each node comprising a capacitor, a positive terminal, and a negative terminal, a plurality of N×M connection units, arranged in N rows and M columns, each connection unit comprising a set of reconfigurable resistive connections, each connection unit configurable to connect a pair of the N nodes via the reconfigurable resistive connections, and a plurality of interconnects, wherein each chip of the plurality of chips is communicatively connected all other chips of the plurality of chips via at least one interconnect. A method of calculating a Hamiltonian of a system of coupled spins is also disclosed.

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

Abstract: Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.

Abstract: Patients with congenital adrenal hyperplasia (CAH) need adequate care and treatment in order to lead normal lives. Hence, there is a need for new methods of treating CAH. This disclosure provides new compounds, salts, compositions and uses thereof in the treatment of CAH.

Abstract: A bistable resistively-coupled system comprises a plurality of visible nodes, a plurality of hidden nodes, and a plurality of coupling elements, each electrically connected to a visible node of the plurality of visible nodes and a hidden node of the plurality of hidden nodes, wherein each of the plurality of coupling elements comprises a programmable resistor. A coupling device for first and second nodes in a network and a method of training a bistable, resistively coupled system are also described.

Abstract: Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity, movement disorders, and related conditions.

Abstract: Systems and methods are described for determining a second entity having a similar trademark portfolio as a first entity. In embodiments, a user submits a request identifying a first entity. A trademark portfolio generator compiles a trademark portfolio of the first entity by accessing a database of trademarks. A trademark portfolio analyzer analyzes the features of the trademark portfolio to form a trademark portfolio profile. A portfolio similarity score calculator determines a trademark portfolio similarity score based by determining the similarity between the trademark portfolio profile of the first entity and trademark portfolio profiles of the second entity. In embodiments, feature vectors related to trademark portfolio profiles of two or more entities are compared to generate portfolio similarity scores. Based on the portfolio similarity scores, a user interface presents the second entity to the user as an entity having a similar trademark portfolio as the first entity.

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

Abstract: An ultrasound imaging system includes an array of ultrasound transducer elements chat send ultrasound energy into an object when energized for respective transmission time periods and provide responses to ultrasound energy emitted from the object for respective reception time periods, a reception modulation circuit modulating the responses with irregular sequences of modulation coefficients, a combiner circuit combining the modulated responses, and an image reconstruction processor configured to computer-process the combined modulated responses into one or more images of the object.

Abstract: The present disclosure provides compositions and methods for intra-articular delivery of anti-CSF1R antibodies to a tissue that is impacted by a disease that is treatable with CSF1/CSF1R inhibition and/or that expresses CSF1R. It was conventional knowledge that the intra-articular dwell time of proteins in joints is typically a few hours or less. The present disclosure shows, however, that intra-articular delivery of an anti-CSF1R antibody can lead to sustained exposure and pharmacologic activity of the antibody in the joints far beyond a few hours, providing an effective means for targeted and extended delivery of the therapeutic agent.

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

Abstract: The present invention provides novel pharmaceutical compositions comprising -(4-Chloro-2-(morpholin-4-yl)thiazol-5-yl)-7-(1-ethylpropyl)-2,5-dimethylpyrazolo(1,5-a)pyrimidine and methods of using the same for the treatment of Congenital adrenal hyperplasia (CAH).

Abstract: The present disclosure provides compositions and methods for intra-articular delivery of anti-CSF1R antibodies to a tissue that is impacted by a disease that is treatable with CSF1/CSF1R inhibition and/or that expresses CSF1R. It was conventional knowledge that the intra-articular dwell time of proteins in joints is typically a few hours or less. The present disclosure shows, however, that intra-articular delivery of an anti-CSF1R antibody can lead to sustained exposure and pharmacologic activity of the antibody in the joints far beyond a few hours, providing an effective means for targeted and extended delivery of the therapeutic agent.

Abstract: An Ising machine having a network of resistively coupled circuit nodes where at least one node comprises a capacitor whose voltage between its terminals represents a state variable of the node and the voltage is resistively coupled to at least one other node in the network and a two-terminal active electronics element connected in parallel with the capacitor supplying energy to the node, and the element having an odd-symmetric current-voltage characteristic exhibiting a negative current gradient for voltages across its terminals that are below a predetermined threshold value in magnitude, and a positive gradient otherwise and zero current for three voltage instances: zero volts, +V1 volts, and ?V1 volts, where V1 is a constant greater than the predetermined threshold.

Abstract: A system and method can be provided for constructing and training a decision tree for machine learning. A training set can be received. The decision tree can be initialized by constructing a root node and a root solver can be trained with the training set. A processor can grow the decision tree by iteratively splitting nodes of the decision tree, where at a node of the decision tree, dimension reduction is performed on features of data of the training set received at the node, and the data having reduced dimension is split based on a routing function, for routing to another node of the decision tree. The dimension reduction and the split can be performed together at the node based on solving a nonlinear optimization problem.