Abstract: A wireless electrostimulation system can comprise a wireless energy transmission source, and an implantable cardiovascular wireless electrostimulation node. A receiver circuit comprising an inductive antenna can be configured to capture magnetic energy to generate a tissue electrostimulation. A tissue electrostimulation circuit, coupled to the receiver circuit, can be configured to deliver energy captured by the receiver circuit as a tissue electrostimulation waveform. Delivery of tissue electrostimulation can be initiated by a therapy control unit.

Abstract: Methods of installing a vascular closure device, the vascular closure device adapted for sealing an opening in biological tissue and comprising an anchor, a compressible plug, a cinch and a suture, the method comprising the steps of providing an insertion sheath, inserting the insertion sheath into the opening in the biological tissue, providing a device sheath having the vascular closure device preloaded therein with a proximal portion of the suture attached to the device sheath, subsequent to the step of inserting the insertion sheath, inserting the device sheath into the insertion sheath, and retracting the insertion sheath and device sheath simultaneously, wherein during the retraction, the insertion sheath and the device sheath are fixed to one another and devices adapted to the methods.

Abstract: The present disclosure relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In one illustrative embodiment, a device is provided for delivering and deploying an anchor, plug, filament, and locking element adjacent to the opening in the vessel wall and/or tissue tract.

Abstract: A medical device system includes an elongated body with a distal end that is configured and arranged for insertion into a patient. A housing is disposed in the distal end of the body. A rotatable magnet is disposed in the housing. At least one magnetic field winding is configured and arranged to generate a magnetic field at the location of the magnet. The magnetic field causes rotation of the magnet at a target frequency. An array of magnetic field sensors is disposed external to the patient. The magnetic field sensors are configured and arranged to sense the location and orientation of the magnet in relation to the array of magnetic field sensors.

Abstract: An imaging assembly comprises a catheter having a distal end and a proximal end, an ablation tip at the distal end of the catheter, and an imaging device disposed within the ablation tip. The catheter defines a catheter lumen that extends from the proximal end to the distal end. The catheter is configured and arranged for insertion into a body lumen such as a blood vessel or heart chamber. The ablation tip has a wall that defines a lumen in communication with the lumen of the catheter. The imaging device is disposed within the lumen of the ablation tip, and is configured to transmit pulsed acoustic waves for generating images of body tissue at a target ablation site within the body.

Abstract: Systems for nerve and tissue modulation are disclosed. An illustrative system may include an intravascular nerve modulation system including a catheter shaft, a first flexible mount, and a cylindrical ablation transducer. The ablation transducer may be affixed to the catheter shaft through the flexible mount to allow an infusion fluid to pass through a lumen of the transducer. Another illustrative system may include an intravascular nerve modulation system including an expandable basket for centering an ablation tra7nsducer within a lumen.

Abstract: A percutaneous pumping system for providing hemodynamic support to a patient includes a pumping sleeve that defines a lumen extending along the length of the pumping sleeve. The pumping sleeve is configured and arranged for insertion into patient vasculature. At least one rotatable magnet is disposed in the pumping sleeve. The at least one first magnet is configured and arranged to be driven to rotate by a magnetic field generated external to the pumping sleeve. At least one impeller is coupled to the at least one magnet. Rotation of the at least one magnet causes a corresponding rotation of the at least one impeller. An anchoring arrangement is coupled to the pumping sleeve. The anchoring arrangement is configured and arranged to anchor the pumping sleeve at a target pumping location when the pumping sleeve is inserted into patient vasculature.

Abstract: Systems for nerve and tissue modulation are disclosed. An example system may include an intravascular nerve modulation system including an elongated shaft having a first tubular member and a second tubular member. Each of the tubular members may have a proximal end a distal end. The distal end of the second tubular member may be extended distally beyond the distal end of the first tubular member. The system may further include at least one transducer affixed to the distal end region of the second tubular member. In addition, the system may include an infusion sheath having a proximal end and a distal end and the proximal end of the infusion sheath may be fixedly secured to the catheter shaft adjacent the distal end of the first tubular member.

Abstract: A wireless electrostimulation system can comprise a wireless energy transmission source, and an implantable cardiovascular wireless electrostimulation node. A receiver circuit comprising an inductive antenna can be configured to capture magnetic energy to generate a tissue electrostimulation. A tissue electrostimulation circuit, coupled to the receiver circuit, can be configured to deliver energy captured by the receiver circuit as a tissue electrostimulation waveform. Delivery of tissue electrostimulation can be initiated by a therapy control unit.

Abstract: Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

Abstract: A percutaneous pumping system for providing hemodynamic support to a patient includes a pumping sleeve that defines a lumen extending along the length of the pumping sleeve. The pumping sleeve is configured and arranged for insertion into patient vasculature. At least one rotatable magnet is disposed in the pumping sleeve. The at least one first magnet is configured and arranged to be driven to rotate by a magnetic field generated external to the pumping sleeve. At least one impeller is coupled to the at least one magnet. Rotation of the at least one magnet causes a corresponding rotation of the at least one impeller. An anchoring arrangement is coupled to the pumping sleeve. The anchoring arrangement is configured and arranged to anchor the pumping sleeve at a target pumping location when the pumping sleeve is inserted into patient vasculature.

Abstract: A wireless electrostimulation system can comprise a wireless energy transmission source, and an implantable cardiovascular wireless electrostimulation node. A receiver circuit comprising an inductive antenna can be configured to capture magnetic energy to generate a tissue electrostimulation. A tissue electrostimulation circuit, coupled to the receiver circuit, can be configured to deliver energy captured by the receiver circuit as a tissue electrostimulation waveform. Delivery of tissue electrostimulation can be initiated by a therapy control unit.

Abstract: A seed assembly for delivery to an interior of a heart includes an electrical stimulation circuit for delivering an electrical stimulus to cardiac tissue. A first electrode assembly is mechanically and electrically coupled to the seed assembly via a micro lead the first electrode assembly configured to deliver the electrical stimulus generated by the electrical stimulation circuit to the cardiac tissue. The seed assembly and the first electrode assembly are sized and shaped to fit entirely within the heart.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device includes a pressure sensing guidewire. The pressure sensing guidewire may include an elongate shaft including a core wire having a distal portion and a coil disposed over the distal portion. A pressure sensor may be disposed along the distal portion of the core wire and within the coil. One or more leads may be coupled to the pressure sensor. An opening may be formed in the coil that provides access to the pressure sensor.

Abstract: Systems for nerve and tissue modulation are disclosed. An example system may include a first elongate element having a distal end and a proximal end and having at least one nerve modulation element disposed adjacent the distal end. The nerve modulation element may be positioned or moveable to target a particular tissue region. The nerve modulation element may be an ultrasound transducer.

Abstract: An imaging assembly for an intravascular ultrasound system includes a catheter, an imaging core, and at least one transducer conductor. The imaging core is insertable into the catheter and extendable from a distal end of the catheter. The imaging core includes a rotatable magnet, a tilted reflective surface, and at least one fixed transducer all disposed in a body. The rotatable magnet is configured and arranged to rotate by a magnetic field generated external to the catheter. The tilted reflective surface rotates with the magnet. The at least one transducer is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. The at least one transducer conductor is electrically coupled to the at least one transducer and is configured and arranged to extend into the catheter when the imaging core is extended from the catheter.

Abstract: Some embodiments of pacing systems employ wireless electrode assemblies to provide pacing therapy. The wireless electrode assemblies may wirelessly receive energy via an inductive coupling so as to provide electrical stimulation to the surrounding heart tissue. In certain embodiments, the wireless electrode assembly may include one or more biased tines that shift from a first position to a second position to secure the wireless electrode assembly into the inner wall of the heart chamber.

Abstract: An implantable cardiac tissue excitation system includes an implantable pacing controller unit with a pulse generation circuit. The system also includes a lead with a lead body extending between a proximal lead end attachable to the pacing controller unit and a distal lead end configured to be implanted within a heart. A lead conductor extends within the lead body. The system also includes a transmitter assembly located near the distal lead end that is electrically connected to the pulse generation circuit through the lead conductor to wirelessly transmit pacing control information and pacing energy. The system also includes a leadless electrode assembly configured to be implanted within the heart that includes a receiver to receive the wireless transmission, a charge storage unit to store the charge energy, and an electrical stimulation circuit to deliver an electrical stimulus to cardiac tissue using the pacing control information and the charge energy.

Abstract: The present disclosure relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In one illustrative embodiment, a device is provided for delivering and deploying an anchor, plug, filament, and locking element adjacent to the opening in the vessel wall and/or tissue tract.

Abstract: Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.