Abstract: Methods of installing a vascular closure device, the vascular closure device adapted for sealing an opening in biological tissue and comprising an anchor, a compressible plug, a cinch and a suture, the method comprising the steps of providing an insertion sheath, inserting the insertion sheath into the opening in the biological tissue, providing a device sheath having the vascular closure device preloaded therein with a proximal portion of the suture attached to the device sheath, subsequent to the step of inserting the insertion sheath, inserting the device sheath into the insertion sheath, and retracting the insertion sheath and device sheath simultaneously, wherein during the retraction, the insertion sheath and the device sheath are fixed to one another and devices adapted to the methods.

Abstract: The present invention relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In one illustrative embodiment, a device is provided for delivering and deploying an anchor, plug, filament, and locking element adjacent to the opening in the vessel wall and/or tissue tract.

Abstract: Methods of installing a vascular closure device, the vascular closure device adapted for sealing an opening in biological tissue and comprising an anchor, a compressible plug, a cinch and a suture, the method comprising the steps of providing an insertion sheath, inserting the insertion sheath into the opening in the biological tissue, providing a device sheath having the vascular closure device preloaded therein with a proximal portion of the suture attached to the device sheath, subsequent to the step of inserting the insertion sheath, inserting the device sheath into the insertion sheath, and retracting the insertion sheath and device sheath simultaneously, wherein during the retraction, the insertion sheath and the device sheath are fixed to one another and devices adapted to the methods.

Abstract: Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrode assemblies that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Also disclosed are various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

Abstract: A catheter assembly for an intravascular ultrasound system includes an imaging core configured and arranged for inserting into a distal end of a lumen of a catheter. The imaging core includes at least one transducer mounted to a driveshaft and configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. A motor is coupled to the driveshaft between the one or more transducers and the transformer. The motor includes a rotatable magnet and at least two magnetic field windings disposed around at least a portion of the magnet.

Abstract: An imaging assembly comprises a catheter having a distal end and a proximal end, an ablation tip at the distal end of the catheter, and an imaging device disposed within the ablation tip. The catheter defines a catheter lumen that extends from the proximal end to the distal end. The catheter is configured and arranged for insertion into a body lumen such as a blood vessel or heart chamber. The ablation tip has a wall that defines a lumen in communication with the lumen of the catheter. The imaging device is disposed within the lumen of the ablation tip, and is configured to transmit pulsed acoustic waves for generating images of body tissue at a target ablation site within the body.

Abstract: Techniques are described that allow intravascular ultrasound (“IVUS”) imaging of patient tissue, e.g., a blood vessel wall, to be performed at one or more angles selected by a clinician, for example. In one example, a method includes receiving user input, via interaction with a user interface, that defines a range of angles through which a scan will be performed, determining, based on the received user input, at least one current value to be applied to at least one lead of a stator of a motor, controlling application of the at least one current to the at least one lead of the stator in order to rotate a rotor of the motor through the range of angles, and through the range of angles, receiving and processing electrical signals from at least one transducer to form at least one image.

Abstract: An apparatus and method can receive wireless energy using a wireless electrostimulation electrode assembly. In certain examples, at least some of the received wireless energy can be delivered as an electrostimulation to a heart. In certain examples, the wireless electrostimulation electrode can be mechanically supported at least partially using a ring formed by an annulus of a mitral valve of the heart. In certain examples, the wireless electrostimulation electrode assembly can be configured to be intravascularly delivered to an implant location within a chamber of the heart at the annulus of the mitral valve of the heart, and can fit entirely within the heart.

Abstract: A system for moving an elongate medical device has at least one drive element for engaging and moving an elongate medical device. Various embodiments provide for moving the separate inner and outer elements of a telescoping medical device. Some systems also provide for the rotation of a rotatable distal element on a rotatable medical device or the rotation of extension element in a telescoping medical device.

Abstract: Devices, systems, and methods associated with pressure sensing are described herein. In one or more embodiments, an intravascular pressure sensing device includes a magnetic sensing element fixedly positioned within a sensor tube, a magnet located a distance from the magnetic sensing element within the sensor tube, the magnet movably positioned within the sensor tube via a ferrofluid magnetically attached to the magnet, and an amount of compressible fluid sealed between the magnetic sensing element and the magnet.

Abstract: Methods of installing a vascular closure device, the vascular closure device adapted for sealing an opening in biological tissue and comprising an anchor, a compressible plug, a cinch and a suture, the method comprising the steps of providing an insertion sheath, inserting the insertion sheath into the opening in the biological tissue, providing a device sheath having the vascular closure device preloaded therein with a proximal portion of the suture attached to the device sheath, subsequent to the step of inserting the insertion sheath, inserting the device sheath into the insertion sheath, and retracting the insertion sheath and device sheath simultaneously, wherein during the retraction, the insertion sheath and the device sheath are fixed to one another and devices adapted to the methods.

Abstract: The present disclosure relates to medical devices and methods, for use in a vascular system. The apparatus includes a balloon catheter having an elongate body, balloon, and fluid control valve for ischemic post-conditioning therapy and/or reperfusion.

Abstract: A percutaneous pumping system for providing hemodynamic support to a patient includes a pumping sleeve that defines a lumen extending along the length of the pumping sleeve. The pumping sleeve is configured and arranged for insertion into patient vasculature. At least one rotatable magnet is disposed in the pumping sleeve. The at least one first magnet is configured and arranged to be driven to rotate by a magnetic field generated external to the pumping sleeve. At least one impeller is coupled to the at least one magnet. Rotation of the at least one magnet causes a corresponding rotation of the at least one impeller. An anchoring arrangement is coupled to the pumping sleeve. The anchoring arrangement is configured and arranged to anchor the pumping sleeve at a target pumping location when the pumping sleeve is inserted into patient vasculature.

Abstract: A medical device system includes an elongated body with a distal end that is configured and arranged for insertion into a patient. A housing is disposed in the distal end of the body. A rotatable magnet is disposed in the housing. At least one magnetic field winding is configured and arranged to generate a magnetic field at the location of the magnet. The magnetic field causes rotation of the magnet at a target frequency. An array of magnetic field sensors is disposed external to the patient. The magnetic field sensors are configured and arranged to sense the location and orientation of the magnet in relation to the array of magnetic field sensors.

Abstract: Some embodiments of an electrode delivery system may be used to deliver a plurality of wired electrodes into one or more chambers of the heart. In particular embodiments, the plurality of wired electrodes may be delivered into a heart chamber through a single guide sheath device. Such a system may be used to deliver one or more wired electrodes to inner wall of the left atrium, the left ventricle, or both.

Abstract: A catheter assembly for an intravascular ultrasound system includes a catheter insertable into patient vasculature via a guidewire. A watertight imaging core is disposed in the distal end of the catheter. The imaging core includes a motor, at least one fixed transducer, and a signal redirection unit. The motor includes a magnet configured and arranged to rotate upon generation of a magnetic field by magnetic field windings. The signal redirection unit is coupled to the magnet such that rotation of the magnet causes a corresponding rotation of at least a portion of the signal redirection unit. The signal redirection unit includes a tilted mirror that redirects acoustic signals transmitted from the fixed transducer to patient tissue. At least one transducer conductor and at least one stator conductor are electrically coupled to the imaging core and in electrical communication with the proximal end of the catheter.

Abstract: The present disclosure relates generally to methods and devices for closing and/or sealing an opening in a vessel wall and/or an adjacent tissue tract. In one illustrative embodiment, a device is provided for delivering and deploying an anchor, plug, filament, and locking element adjacent to the opening in the vessel wall and/or tissue tract.

Abstract: Some embodiments of pacing systems employ wireless electrode assemblies to provide pacing therapy. The wireless electrode assemblies may wirelessly receive energy via an inductive coupling so as to provide electrical stimulation to the surrounding heart tissue. In certain embodiments, the wireless electrode assembly may be pivotable so that the proximal end of the wireless electrode assembly may be shifted to a position against the heart wall after the distal end has been secured to the heart wall.

Abstract: A system for moving an elongate medical device has at least one drive element for engaging and moving an elongate medical device. Various embodiments provide for moving the separate inner and outer elements of a telescoping medical device. Some systems also provide for the rotation of a rotatable distal element on a rotatable medical device or the rotation of extension element in a telescoping medical device.

Abstract: An imaging core, that is configured and arranged for insertion into a catheter, includes a mirror disposed at a distal end of a rotatable driveshaft; a motor coupled to the driveshaft and including a rotatable magnet and at least two magnetic field windings disposed around at least a portion of the magnet on a rigid slotted material; and at least one fixed transducer positioned between the motor and the rotatable mirror. The driveshaft extends through an aperture in the magnet to allow passage of the driveshaft through the at least one transducer to the rotatable mirror. At least one transducer conductor is electrically coupled to the at least one transducer and in electrical communication with the proximal end of the catheter. At least one motor conductor is electrically coupled to the magnetic field windings and in electrical communication with the proximal end of the catheter.