Abstract: The present disclosure provides peptides that modulate an immune response in an individual. The present disclosure provides peptides that modulate cellular responses in vitro. The present disclosure provides compositions comprising the peptides. The peptides and compositions are useful in methods of modulating an immune response in an individual, which methods are also provided.

Abstract: A system for releasing an additive manufactured part from a build location is disclosed having a cure inhibitor transport system to resupply a cure inhibitor at a cure inhibited photopolymer resin layer where the additive manufactured part is built, the transport system comprises a cure inhibiting reservoir to initially hold the cure inhibitor, a cure inhibiting distributor layer adjacent to the cure inhibiting reservoir through which the cure inhibitor passes from the cure inhibitor reservoir to the cure inhibited photopolymer resin layer and into the adjacent photopolymer creating a cure inhibited photopolymer resin layer. Another system and method are also disclosed.

Abstract: A system for releasing an additive manufactured part from a build location is disclosed having a cure inhibitor transport system to resupply a cure inhibitor at a cure inhibited photopolymer resin layer where the additive manufactured part is built, the transport system comprises a cure inhibiting reservoir to initially hold the cure inhibitor, a cure inhibiting distributor layer adjacent to the cure inhibiting reservoir through which the cure inhibitor passes from the cure inhibitor reservoir to the cure inhibited photopolymer resin layer and into the adjacent photopolymer creating a cure inhibited photopolymer resin layer. Another system and method are also disclosed.

Abstract: A sealing membrane assembly including a flange having a body with a through passage. A first sealing membrane defines a first flexible panel with a first axial sealed opening extending therethrough. The first axial sealed opening extends at an acute angle. A second sealing membrane defines a second flexible panel with a second axial sealed opening extending therethrough. The second axial sealed opening extends at an obtuse angle. The first and second sealing membranes are secured relative to the flange such that the first and second axial sealed openings crisscross one another and the first and second sealing membranes seal the through passage except through the first and second sealed openings.

Abstract: Systems, methods and computer program products are disclosed that facilitate measuring the light output of an additive manufacturing device light source without utilizing additional equipment, such as a light meter. Once the light source output has been measured, such information can be utilized for a variety of purposes, including, but not limited to: (i) delivering a uniform amount of light energy over time to each portion of a layer being formed; (ii) adjusting the intensity of each controllable element (e.g., pixel) of the light source to the measured minimum, thereby creating a uniformly intense light source; and (iii) minimizing the build time of layers or portions of a layer being formed based on the maximum intensity available within a given area of the build area.

Abstract: A system and method for guiding the placement of a peripherally inserted central catheter in a patient is provided. The system includes a peripherally inserted central catheter; at least one sensor configured to be coupled to said catheter and structured to sense and transmit an electrical signal associated with a P wave; a data base including known data corresponding to standard and non-standard P waves including peaks, deflections and transition points; and a processing device in operable communication with said at least one sensor and said data base, said processing device configured to receive said electrical signal and identify P waveform attributes of said signal, cross-reference said waveform attributes and said electrical signal with known data in said base data, and output indicia representative of said P waveform attributes and said signal based on said cross-reference.

Abstract: An embodiment of the present disclosure is an acoustic logging tool for determining a characteristic of a ground formation during a drilling operation. The acoustic logging tool includes a transmitter section that houses a transmitter that is configured to emit an acoustic signal and a receiver section spaced from the transmitter section along an axial direction. The receiver section includes a receiver that is configured to receive at least a portion of the acoustic signal. The acoustic logging tool also includes an isolator section positioned between the transmitter section and the receiver section along the axial direction.

Abstract: A system for releasing an additive manufactured part from a build location is disclosed having a cure inhibitor transport system to resupply a cure inhibitor at a cure inhibited photopolymer resin layer where the additive manufactured part is built, the transport system comprises a cure inhibiting reservoir to initially hold the cure inhibitor, a cure inhibiting distributor layer adjacent to the cure inhibiting reservoir through which the cure inhibitor passes from the cure inhibitor reservoir to the cure inhibited photopolymer resin layer and into the adjacent photopolymer creating a cure inhibited photopolymer resin layer. Another system and method are also disclosed.

Abstract: A method including creating an additive manufactured part layer by layer with an additive manufacturing device, determining, with a processor, at least one of a speed and a rate at which the additive manufacturing device at least one of lifts, delays, and lowers the part with respect to a build plate after an additive layer has been added to the part based on sizing information about the part being built at least one of real-time during the build process and prior to beginning the build process, and operating the additive manufacturing device at one of the speed and the rate during a build process of the part to create the part. Another method is also included.

Abstract: A vehicle traction mat for use to extricate a vehicle stuck on a slippery road surface is provided. The traction mat comprises at least a main mat segment having a plurality of surface cleats, knobs, and knob cleats on a road-facing surface thereof. The cleats and knobs provide traction between the traction mat and the slippery surface. The traction mat may be provided with edge mat segments foldably connected to opposite ends of the main mat segment. The traction mat may have cleats, knobs, and knob cleats on the tire-facing surface thereof.

Abstract: Devices, systems and methods are disclosed which facilitate reduction of separation forces in additive manufacturing devices, thereby enabling creation of higher resolution parts. In an aspect, an additive manufacturing device utilizing a photopolymer comprises a vat holding photocurable resin, a build platform movable in a vertical direction and an image source which selectively projects part cross sections into the vat in order to polymerize the resin and form a part in a layer-wise fashion. The image area of the vat is formed by a transparent film, such as Teflon FEP film, stretched under tension. A horizontally slideable shutter is slideable between the film and the imager, providing support for the film when needed.

Abstract: Devices, systems, methods and computer program products are disclosed that facilitate part layer curing by an additive manufacturing device wherein each element of the part layer is exposed to light from a light source until the element receives sufficient energy to cure. In an aspect, received energy is calculated based on both the light received directly from the light source and light received from surrounding elements due to dispersion and other effects. The present disclosure enables consistent curing across a part layer, facilitate the creation of sharp outer structures, and allow fragile structures to be built alongside larger structures without a loss of quality, clarity, or resolution.

Abstract: The present disclosure provides methods and compositions relating to in vitro cultures of human hepatocyte cell lines which exhibit a primary human hepatocyte phenotype. Such cell lines are susceptible to infection by a hepatotrophic virus, such as HCV or HBV, and support both viral replication and high levels of viral particle production. Such in vitro cultures find use in production and study of hepatotrophic virus, as well as methods of screening (e.g., for antiviral drugs, assessing drug metabolism), and study of primary human hepatocytes.

Abstract: An impact sensing system includes a first impact sensor having a flexible dielectric layer, a first printed electrode on a first side of the layer, and a second printed electrode on a second side of the layer. The second printed electrode overlies and is moveable toward and away from the first electrode by deformation of the flexible dielectric layer. Further, the layer maintains a capacitance between to the first electrode and the second electrode that changes with a movement of the second electrode toward or away from the first electrode. The system further includes a first readout circuit electronically coupled with the first and second electrodes to measure a change in the capacitance and output a corresponding voltage.

Abstract: Devices, methods, and computer program products for facilitating the assembly of three-dimensional parts in a layer-wise fashion are disclosed, wherein separation forces between the assembler device and the parts are minimized at certain interfaces. Parts may be produced from polymers, photopolymers, metals, or other materials. In some aspects of the present disclosure, separation forces are minimized via the utilization of a cure inhibiting layer on a top surface of the image plate and via sliding the part from contact with a portion of the image plate having high elevation to above a portion of the image plate with low elevation. In some aspects, the assembler device further comprises a sweeper configured to expose the cure inhibiting layer to a source of cure inhibitor after a cure cycle.

Abstract: A gap services router (GSR) that is a drop-in replacement of an end of life Cisco™ 2811 integrated services router (ISR). The GSR is a routing, switching, and computing platform that provides a technology refresh in the same form factor as the legacy 2811 router. The GSR is one rack unit in size and comprises the latest routing and switching technology from Cisco™, preferably a Cisco™ 5915 embedded services router (ESR) and a Cisco™ embedded services 2020 switch. The GSR contains two WAN ports and twenty-five LAN ports, with power over ethernet capability on all ports. The GSR also optionally includes an embedded server module capable of running the latest virtualization technology. An embedded server module in the GSR includes a removable solid state drive (SSD) that is zeroed upon removal. The GSR is preferably used to replace 2811 ISRs integrated in deployed military equipment.

Abstract: A replenishing device in an additive manufacturing system is disclosed having a sweeper that extends to a base of a reservoir that holds a liquid resin and horizontally across at least a portion of a cure inhibiting layer located on the base of the reservoir that functions as an imaging plate, with the sweeper positioned across at least a portion of a side of the cure inhibiting layer to at least one of retard a flow of the liquid resin across a portion of a top surface of the cure inhibiting layer by providing a physical barrier to the liquid resin, remove debris from the cure inhibiting layer, and agitate the liquid resin. Other devices are also disclosed.

Abstract: Devices, systems and methods are disclosed which facilitate reduction of separation forces in additive manufacturing devices, thereby enabling creation of higher resolution parts. In an aspect, an additive manufacturing device utilizing a photopolymer comprises a vat holding photocurable resin, a build platform movable in a vertical direction and an image source which selectively projects part cross sections into the vat in order to polymerize the resin and form a part in a layer-wise fashion. The image area of the vat is formed by a transparent film, such as Teflon FEP film, stretched under tension. A horizontally slideable shutter is slideable between the film and the imager, providing support for the film when needed.