Abstract: The disclosure is directed to treatment regimens for treating Multiple Sclerosis (MS). These methods utilize administration of ofatumumab, an anti-CD20 monoclonal antibody, to the patient during a loading dose regimen and a maintenance regimen.

Abstract: Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or C1-C6 alkyl; ring A is cyclohexyl or phenyl, optionally substituted; ring B is aryl or a nitrogen-containing heteroaryl, optionally substituted; ring C is phenyl substituted with hydroxyl; each L1, L2 and L3 is independently C1-C6 alkyl, —CONR2— or —CONR2—X—C1-C6 alkyl-, each optionally substituted; R2 is hydrogen or C1-C6 alkyl; and X is a bond or a 5-6 membered heterocycle containing up to 3 ring heteroatoms; and methods of use such as a method for increasing hematopoiesis, for enhancing expansion of a hematopoietic stem cell (HSC), or for inhibiting an interaction between a ?-, and/or ?-catenin protein in a cell or a subject by administering a compound of Formula (I) to the subject.

Abstract: Described herein are devices and systems relating to sports training equipment, for example, for baseball. These devices and systems can comprise a mat with markers identifying a plurality of positions on the mat. In some embodiments, the system can comprise removably attachable footpads to identify ideal foot positions for an athletic performance. In some embodiments, the footpads comprise one or more pressure sensors. The system can comprise one or more position sensors on a ball, and one or more position sensors removably attachable to a hand-held sports instrument. In some embodiments, the system can comprise a memory, communicatively coupled to a processor and a camera, with executable instructions to implement a set-up component, a user recognition component, a practice component, and instructional component, and a play component.

Abstract: Provided are: methods for treating aging or an age-related condition, symptom or disease; methods for stimulating hair growth, regrowth or pigmentation (or preventing hair loss); methods for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); methods for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of a CBP/catenin (e.g., CBP/?-catenin) antagonist as disclosed, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g.

Abstract: Provided are: composition and methods for: treating aging or an age-related condition, symptom or disease; stimulating hair growth, regrowth or pigmentation (or preventing hair loss); for increasing adenosine receptor expression in dermal cells (in combination with hair growth); for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrancy). The methods comprise administering a sufficient amount of the disclosed CBP/catenin (e.g., CBP/(?-catenin) antagonist compositions, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g.

Abstract: Provided are composition and methods for treating radiation-induced cell damage, and in particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced induced depletion of tissue stem cells and injury to the supportive stem cell niche, and in even more particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced gastrointestinal syndrome (RIGS), comprising sequential administration of a Wnt pathway activator/agonist (e.g., Rspo1 or a small molecule inducer thereof) that amplifies the surviving intestinal stem cell (ISC) pool post-radiation exposure, followed by a selective antagonist of the ?-Catenin-CBP interaction (e.g., ICG-001 or other exemplary compounds disclosed herein) that accelerates differentiation of the stimulated (e.g., Rspo1-stimulated) ISC in crypt-villi axis, promoting villous regeneration and intestinal restitution, thereby mitigating RIGS. Adjunctive and combination therapy embodiments are encompassed.

Abstract: A method of converting a recliner from manual actuation to powered actuation that includes providing a recliner having a frame, a recliner mechanism with a base coupled to the frame and a hinged linkage movably coupled to the base, and a manual actuator that releases the hinged linkage to move under an occupant-applied force. The method also includes disconnecting and removing the manual actuator from the recliner and, without disassembly of the recliner mechanism from the frame, removing a spring assist device extending between the hinged linkage and the base, installing a drive unit to the recliner mechanism, installing a power actuator on the frame with electrical communication to the drive unit, and establishing electrical communication between the drive unit and a source of electrical power, so that activation of the power actuator causes the drive unit to move the hinged linkage under powered actuation.

Abstract: Provided are: composition and methods for: treating aging or an age-related condition, symptom or disease; stimulating hair growth, regrowth or pigmentation (or preventing hair loss); for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of the disclosed CBP/catenin (e.g., CBP/B-catenin) antagonist compositions, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g.

Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

Abstract: A method of converting a recliner from manual actuation to powered actuation that includes providing a recliner having a frame, a recliner mechanism with a base coupled to the frame and a hinged linkage movably coupled to the base, and a manual actuator that releases the hinged linkage to move under an occupant-applied force. The method also includes disconnecting and removing the manual actuator from the recliner and, without disassembly of the recliner mechanism from the frame, removing a spring assist device extending between the hinged linkage and the base, installing a drive unit to the recliner mechanism, installing a power actuator on the frame with electrical communication to the drive unit, and establishing electrical communication between the drive unit and a source of electrical power, so that activation of the power actuator causes the drive unit to move the hinged linkage under powered actuation.

Abstract: The invention provides ?-helix mimetic structures and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of diseases including fibrosis, such as pulmonary fibrosis.

Abstract: Provided are: methods for treating aging or an age-related condition, symptom or disease; methods for stimulating hair growth, regrowth or pigmentation (or preventing hair loss); methods for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); methods for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of a CBP/catenin (e.g., CBP/?-catenin) antagonist as disclosed, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g.

Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

Abstract: The invention provides ?-mimetic structures represented by Formula (VI) and a chemical library relating thereto. Additionally, the invention provides methods wherein ?-mimetic compounds are used to treat cancer stem cells.

Abstract: A system includes multiple input ports that forward received data (e.g., data packets) to each of multiple queues. Data received at the input ports of the system can be somewhat random or “bursty” at times. That is, the input ports can receive data at a variable bit rate or unspecified bit rate from an internal system source or an external source such as an FTP (File Transfer Protocol) server or SCSI disk array. The queues output data at a constant bit rate. A two-dimensional scheduler associated with the system forces random inbound server traffic from the input ports to adhere to a QoS (Quality of Service) agreement such that the random nature of the inbound traffic does not negatively affect the deterministic guarantees of existing server traffic output from the queues. In other words, techniques herein ensure adherence to QoS requirements among the data flows, without overflowing the queues.

Abstract: A single data bus to a memory device can be split up into a number of data bus portions, each of which is managed by a different respective controller chip of multiple controller chips. During a memory access to a respective memory device, each of the multiple controller chips controls a different corresponding portion of the data bus to retrieve data from or store data to the memory device depending on whether the access is a read or write. To perform the data access, a synchronizer circuit (internal and/or external to the memory controller chips) synchronizes the multiple memory controller chips such that one of the memory controller chips drives the address bus and/or control signals to the memory device. After setting the address to the memory device, the memory controller chips either read data from or write data to the memory device based on the address.

Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.