Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

Abstract: ?-sheet mimetics and methods relating to the same are disclosed. The ?-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a ?-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.

Abstract: There are disclosed ?-sheet mimetics and methods relating to the same for imparting or stabilizing the ?-sheet structure of a peptide, protein or molecule. In one aspect, ?-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the ?-sheet mimetic is a thrombin inhibitor.

Abstract: There are disclosed ?-sheet mimetics and methods relating to the same for imparting or stabilizing the ?-sheet structure of a peptide, protein or molecule. In one aspect, ?-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the ?-sheet mimetic is a thrombin inhibitor.

Abstract: A method, system, and apparatus for configuring a signal processing device for use with a display device having a display size is disclosed. The signal processing device is configured by determining the display size of the display device and configuring the signal processing device for use with the display device based on the determined display size.

Abstract: A method for rapidly accessing program guide information is described. The method includes displaying program guide information on a grid showing a channel axis and a time axis, with each program positioned at a location in the grid representing a channel of transmission and a corresponding time of transmission. The method includes the steps of: (a) displaying the program guide information; (b) placing a time selection field on the display; (c) highlighting and activating the time selection field; (d) determining a time index in response to the activating step; (e) calculating a new time of transmission for display based on the time index; and (f) displaying the program guide information at the new time of transmission. The time selection field includes a page field, a day field and a date field. The page field is adapted to provide a six-hour time index, the day field is adapted to provide a 24-hour time index, and the date field is adapted to provide a seven-day time index.

Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

Abstract: A system and associated method of converting audio data from a television signal into textual data for display as a closed caption on an display device is provided. The audio data is decoded and audio speech signals are filtered from the audio data. The audio speech signals are parsed into phonemes in accordance by a speech recognition module. The parsed phonemes are grouped into words and sentences responsive to a database of words corresponding to the grouped phonemes. The words are converted into text data which is formatted for presentation on the display device as closed captioned textual data.

Abstract: A method and system for information presentation in an online trading environment are described. According to one aspect of the invention, the sales price of the item, plus any applicable taxes, shipping, and any applicable payment surcharge are included in the total cost displayed for each item. The list of items may optionally be sorted according to the total cost of the item. According to another aspect of the invention, the sales price of the item plus any applicable taxes and payment surcharges are included in the total cost displayed for each item, but the shipping charges are not included, thereby providing an accurate total cost when the item will be received in-person, thereby avoiding shipping charges.

Abstract: A method and apparatus for switching a cable television receiver from a non-module tuning mode to a module tuning mode is disclosed. To switch from the non-module tuning mode to the module tuning mode, a cable tuning module is detected, module tuning data is acquired, and the cable television receiver is switched from the non-module tuning mode to the module tuning mode responsive to a measure of the acquired module tuning data.

Abstract: The present invention provides compounds and methods for modulating transcription activated by ?-catenin/TCF, such as the selective inhibition of genes targeted by the Wnt/?-catenin pathway.

Abstract: The invention provides an adduct comprising a carbon nanotube and a transitional metal coordination complex, wherein the metal of the complex is attached by a covalent linkage to at least one oxygen moiety on the nanotube.

Abstract: A method, system, and apparatus for configuring a signal processing device for use with a display device having a display size is disclosed. The signal processing device is configured by determining the display size of the display device and configuring the signal processing device for use with the display device based on the determined display size.

Abstract: There are disclosed &bgr;-sheet mimetics and methods relating to the same for imparting or stabilizing the &bgr;-sheet structure of a peptide, protein or molecule. In one aspect, &bgr;-sheet mimetics are disclosed having utility as protease inhibitors in general and, more specifically, as serine protease inhibitors such as thrombin, elastase and Factor X inhibitors. In one embodiment, the &bgr;-sheet mimetic is a thrombin inhibitor.

Abstract: Methods, systems, and apparatus to customize television channel lists are disclosed. The television channel lists are updated by adding/deleting ranges of channels from the channel list where the channel ranges are defined by a user.

Abstract: A method, apparatus, and system for returning to a previously viewed channel is disclosed. A user defines a preferred time period for a timed return feature. A viewer then invokes the timed return feature while viewing a primary channel presented on a display device associated with a television receiver. The timed return feature allows the viewer to view channels other than the primary channel during the preferred time period. At the end of the preferred time period, the primary channel is again presented to the viewer on the display device. The preferred time period is retained in memory so that each time the timed return feature is invoked, the preferred time period is used for the timed return feature.

Abstract: The invention involves compounds having the general formula (I) as described in the claims and pharmaceutical compositions comprising such compounds. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer.

Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

Abstract: Conformationally constrained compounds which mimic the secondary structure of &bgr;-strand regions of biologically active peptides and proteins are disclosed. Such &bgr;-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the &bgr;-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.