Patents by Inventor Michael Koehler

Michael Koehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080042505
    Abstract: The invention relates to a method for the production of a soft magnetic core for generators and generator with a core of this type. To produce a core, a plurality of magnetically activated and/or magnetically activatable textured laminations is produced from a CoFeV alloy. This plurality of laminations is then stacked to form a core assembly. Then the core assembly, if consisting of magnetically activatable laminations, is magnetically activated. Finally, the magnetically activated core assembly is eroded to produce a soft magnetic core. A core of this type is suitable for a generator with a stator and a rotor for high-speed aviation turbines, the laminations in the core assembly being oriented in different texture directions relative to one another.
    Type: Application
    Filed: July 18, 2006
    Publication date: February 21, 2008
    Applicant: Vacuumschmelze GMBH & Co. KG
    Inventors: Joachim Gerster, Witold Pieper, Rudi Ansmann, Michael Koehler, Michael Von Pyschow
  • Patent number: 7263445
    Abstract: The invention relates to a method for the simultaneous dissection in specific positions of filiform organic molecular chains, in particular DNA. The aim of the invention is to provided a method, by which a highly specific dissection can take place on certain sequences that can be freely selected and simultaneously on numerous filiform molecules. To achieve this, nanoparticles (1) are provided with a molecular chain (11) of any predeterminable sequence, which is selected to be complementary to a sequence of a molecule (2) that is to be dissected, said molecular chain(s) (11) is/are hybridised in the usual manner with the molecule, or specifically linked to said molecule in another manner and the nanoparticles (1) are subsequently subjected to a high-energy radiation of at least one wavelength, which can be absorbed by said nanoparticles (1).
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: August 28, 2007
    Inventors: Wolfgang Fritzsche, Karsten Koenig, Johann Michael Koehler
  • Patent number: 7168202
    Abstract: Hook holder (1) for a hook (4), especially a fish hook, having a shank (5) and one or more curved end (portions) extending from the shank, said hook holder including a container part (2) provided with a cavity (7) for accommodating the curved end portions of the hook, and a container opening (8)through which the curved end portions of the hook are insertable into the cavity. The hook holder further includes retaining means to prevent the hook's curved end portions from unintentionally leaving the container part.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: January 30, 2007
    Inventor: Michael Køhler
  • Publication number: 20070014090
    Abstract: An apparatus includes a heat receiving portion which receives heat within a footprint from a heat generating structure, and a cooling arrangement which causes flow of a coolant that absorbs heat at the heat receiving portion, the cooling arrangement being disposed in its entirety within a width of the footprint in a particular direction. A different feature involves an apparatus which includes a heat receiving portion at which a coolant receives heat, and a coolant separating portion which receives coolant traveling away from the heat receiving portion, and which separates liquid coolant from vapor coolant.
    Type: Application
    Filed: September 19, 2006
    Publication date: January 18, 2007
    Applicant: Raytheon Company
    Inventors: Richard Weber, George Barson, Michael Koehler
  • Patent number: 7118711
    Abstract: The invention relates to a microcolumn reactor for carrying out reactions on solid phases and/or with biological cells. The aim of the invention is to provide a microcolumn reactor for processes of synthesis and separation on small sample volumina that replaces an alternating sequence of binding and elution processes on a phase that is stationary bound during a test series and makes it possible to exchange the stationary phase, for example once it has been loaded. To this end, the microcolumn reactor consists of at least one first and one second substrate wafer (1; 2) that are linked with one another across their surfaces. At least one of the substrate wafers (1; 2) is provided with an elongate channel (3) which comprises in a defined section (a) of its length two passage openings (41, 42) that are implemented in the opposite substrate wafer. Said openings (41, 42) are separated from the channel (3) by a partially permeable sieve-type membrane (5).
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: October 10, 2006
    Assignee: Clondiag Chip Technologies GmbH
    Inventor: Johann Michael Koehler
  • Publication number: 20060135430
    Abstract: The present invention relates to polypeptides that block BLyS signaling, nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related disease or cancer using the polypeptides and compositions of the invention. The present invention also relates to methods for identifying inhibitors of BLyS signaling.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 22, 2006
    Applicant: GENENTECH, INC.
    Inventors: Andrew Chan, Nathaniel Gordon, Robert Kelley, Michael Koehler, Melissa Starovasnik
  • Patent number: 7045494
    Abstract: A process for making an alkyl and/or alkenyl oligoglycoside preparation having a magnesium salt concentration of less than about 10 ppm involving the steps of: (a) providing an alkyl and/or alkenyl oligoglycoside preparation having an active substance content of from about 10 to 70% by weight, based on the weight of the preparation; (b) providing an acid component; (c) adjusting the pH of the alkyl and/or alkenyl oligoglycoside preparation to from about 4 to 9.5 by combining the acid component with the alkyl and/or alkenyl oligoglycoside preparation to form a pH-modified alkyl and/or alkenyl oligoglycoside preparation; (d) providing a column charged with an ion exchange resin; and (e) purifying the pH-modified alkyl and/or alkenyl oligoglycoside preparation by passing it through the column of step (d) at a viscosity of from about 20 to 6,000 mPas, and at a temperature of from about 20 to 90° C.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: May 16, 2006
    Assignee: Cognis Deutschland GmbH & Co. KG
    Inventors: Thomas Albers, Karl Heinz Schmid, Rainer Eskuchen, Michael Koehler
  • Patent number: 7002683
    Abstract: A measuring head for determining particle size in transparent media, comprising a measuring head body which has an opening for an optical measuring point with two measuring windows, consisting of an illuminating device and a light receiving device which is connected to an opto-electronic converter device. A rinsing device is used to clean the optical measuring point. The windows can be reliably prevented from becoming fouled or wetted by particles contained in the particle flow, enabling optical permeability of the measuring point and avoiding false measuring values. The rinsing device has a rinsing medium source, a channel extending to the opening inside the measuring head body for delivery of a rinsing medium and at least one discharge opening near the opening, which extends perpendicularly to and directly in front of the measuring windows. At least one defined rinsing jet is spread over the surfaces of the measuring windows.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: February 21, 2006
    Assignee: Parsum-Gesellschaft für Partikel-Strömungs-und Umweltmesstechnik mbH
    Inventors: Günter Eckardt, Stefan Dietrich, Michael Köhler
  • Publication number: 20050248749
    Abstract: The invention relates to a method for distance measurement by determining the pulse transit time, in which pulsed electromagnetic radiation is transmitted using at least one transmitter and signal pulses reflected at objects are detected using at least one receiver, wherein at least one received logic signal containing logic signals is generated from the received analog signal containing the signal pulses, in particular by means of a threshold circuit, and is evaluated with respect to the transit times of the logic signals, and wherein the received logic signal is read into a programmable logic circuit by means of a clocked data reading device and is mapped onto a time pattern in the logic circuit, in that instantaneous values of the received logic signal are stored in logic units of the logic circuit associated with the time windows for time windows of the time pattern corresponding to at least one clock pulse of the data reading device.
    Type: Application
    Filed: May 9, 2005
    Publication date: November 10, 2005
    Applicant: IBEO Automobile Sensor GmbH
    Inventors: Michael Kiehn, Kirsten Gosch, Michael Köhler, Volker Willhoeft
  • Publication number: 20050243519
    Abstract: An apparatus includes a heat receiving portion which receives heat within a footprint from a heat generating structure, and a cooling arrangement which causes flow of a coolant that absorbs heat at the heat receiving portion, the cooling arrangement being disposed in its entirety within a width of the footprint in a particular direction. A different feature involves an apparatus which includes a heat receiving portion at which a coolant receives heat, and a coolant separating portion which receives coolant traveling away from the heat receiving portion, and which separates liquid coolant from vapor coolant.
    Type: Application
    Filed: June 15, 2005
    Publication date: November 3, 2005
    Inventors: Richard Weber, George Barson, Michael Koehler
  • Publication number: 20050176616
    Abstract: A process for making an alkyl and/or alkenyl oligoglycoside preparation having a magnesium salt concentration of less than about 10 ppm involving the steps of: (a) providing an alkyl and/or alkenyl oligoglycoside preparation having an active substance content of from about 10 to 70% by weight, based on the weight of the preparation; (b) providing an acid component; (c) adjusting the pH of the alkyl and/or alkenyl oligoglycoside preparation to from about 4 to 9.5 by combining the acid component with the alkyl and/or alkenyl oligoglycoside preparation to form a pH-modified alkyl and/or alkenyl oligoglycoside preparation; (d) providing a column charged with an ion exchange resin; and (e) purifying the pH-modified alkyl and/or alkenyl oligoglycoside preparation by passing it through the column of step (d) at a viscosity of from about 20 to 6,000 mPas, and at a temperature of from about 20 to 90° C.
    Type: Application
    Filed: June 12, 2002
    Publication date: August 11, 2005
    Inventors: Thomas Albers, Karl Schmid, Rainer Eskuchen, Michael Koehler
  • Patent number: 6903066
    Abstract: Processes for preparing light-colored alkyl and/or alkenyl oligoglycoside mixtures are disclosed. The processes disclosed include providing an initial mixture of an alk(en)yl oligoglycoside and a rheology-modifying agent, the mixture having a viscosity of from 10 to 1000 mPas at a temperature of from 85 to 130° C., and a water content of less than 2% by weight, based on the alk(en)yl oligoglycoside; and bleaching the initial mixture at a temperature of from 85 to 130° C. to form a light-colored surfactant mixture having a water content of less than 2% by weight, based on the alk(en)yl oligoglycoside. Also disclosed is the use of such mixtures in cleaning compositions, such as detergents, washing and dishwashing compositions.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: June 7, 2005
    Assignee: Cognis Deutschland GmbH & Co. KG
    Inventors: Ditmar Kischkel, Werner Leinemann, Rainer Eskuchen, Michael Koehler, Manfred Weuthen
  • Patent number: 6896855
    Abstract: A miniaturized temperature-zone flow reactor, used for thermally controlled biochemical or molecular-biological processes, especially polymerase chain reaction (PCR) enables more efficient reactions by providing at least one closed flow path which is divided into three partial paths (A1 . . . An; B1 . . . Bn and BB1 . . . BBn?1; C1 . . . Cn) with the reactor having three substrate chips (A; B; C) which are made of a material having a high heat conductivity, and which have defined channel sections that are spaced apart relative to each other, and are connected by a connecting chip (V) made of a poor heat-conductive material. The substrate chips (A; B; C) are maintained at different temperatures by various means, including the use of controlling heating elements in contact with the chips.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: May 24, 2005
    Assignee: Institut fuer Physikalische Hochtechnologie e.V.
    Inventors: Johann Michael Köhler, Andreas Mokansky, Siegfried Poser, Torsten Schulz
  • Publication number: 20050094373
    Abstract: An apparatus includes a heat receiving portion which receives heat within a footprint from a heat generating structure, and a cooling arrangement which causes flow of a coolant that absorbs heat at the heat receiving portion, the cooling arrangement being disposed in its entirety within a width of the footprint in a particular direction. A different feature involves an apparatus which includes a heat receiving portion at which a coolant receives heat, and a coolant separating portion which receives coolant traveling away from the heat receiving portion, and which separates liquid coolant from vapor coolant.
    Type: Application
    Filed: October 31, 2003
    Publication date: May 5, 2005
    Inventors: Richard Weber, George Barson, Michael Koehler
  • Patent number: 6878539
    Abstract: The invention relates to an affinity sensor for detecting specific molecular binding events, for use in the field of molecular biology, e.g., in medical diagnostics, especially in biosensor technology or in DNA microarreay tests. The aim of the invention is to provide an affinity sensor of this type for rapidity, sensitively, specifically, economically and routinely detecting the presence of molecules, especially bioactive molecules, and to provide special applications for an affinity sensor of this type. To this end, the affinity sensor consists of a support substrate which is provided with at least two electrodes. The electrodes are situated equidistantly from each other and cover an area on both sides, at least this area being provided for receiving immobilized specific binding partners which are capable of coupling complementary corresponding binding partners directly or with other specific binding molecules.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: April 12, 2005
    Assignee: Genetrix B.V.
    Inventors: Wolfgang Fritzsche, Andrea Czaki, Johann Michael Köhler, Antje Wiegand, Louis Oosting, Frederik Schut, Paris Som Tjwan Tan
  • Patent number: 6821692
    Abstract: The present invention relates to novel thin layers for microsystem techniques and microstructuring. It is an object of the invention to provide thin layers which can be manufactured under less problems and more economically than the previous conventional layers, and which permit the use of existing technologies for microstructuring. The object is realized in that the thin layer is formed of an enzymatically degradable biopolymer in a range of layer thicknesses of from 30 nm to 3 &mgr;m. Biopolymeric thin layers manufactured according to the invention permit their application, after a respective structurizing, as test assays or in setting up substance libraries.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: November 23, 2004
    Assignee: Clondiag Chip Technologies GmbH
    Inventors: Eugen Ermantraut, Johann Michael Köhler, Torsten Schulz, Klaus Wohlfart, Stefan Wölfl
  • Patent number: 6723135
    Abstract: A laundry detergent composition containing a surfactant system having: (a) an alkyl and/or alkenyl oligoglycoside; (b) from about 5 to 35% by weight of a fatty alcohol; and (c) up to 2% by weight water, all weights being based on the weight of the surfactant system.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: April 20, 2004
    Assignee: Cognis Deutschland GmbH & Co. KG
    Inventors: Rainer Eskuchen, Ditmar Kischkel, Manfred Weuthen, Michael Koehler, Werner Leinemann
  • Patent number: 6645744
    Abstract: A bath for generating microstructures which is required in numerous fields of application of the microsystem technique and in microstructuring offers a less expensive alternative to known conventional approaches and disposal of the used bath may be carried out in a manner more environmentally friendly manner than in the previous methods for manufacture of microstructures. The bath includes at least one biogenic agent (in particular, an enzyme) which acts upon a preselectable thin layer.
    Type: Grant
    Filed: February 5, 1999
    Date of Patent: November 11, 2003
    Assignee: Clondiag Chip Technologies GmbH
    Inventors: Eugen Ermantraut, Johann Michael Köhler, Torsten Schulz, Klaus Wohlfart
  • Publication number: 20030087277
    Abstract: The present invention relates to an affinity sensor and methods suitable for use in an affinity sensor for detecting specific molecular binding events, as is particularly used in the molecular biological field, for example, in the medical diagnostics, in the biosensor technology or in the DNA-microarray technology, and application of the same. A method for detecting binding of members of a specific binding pair of the invention comprises providing a first member of said binding pair coupled to a deposition nucleus and specifically binding said first member to a surface-immobilized second member of said pair and determining the electrical resistance of said surface, the method characterized in that after binding of the members on said surface an electrically conductive deposit is formed on said surface under conditions that allow said deposit to be formed specifically on said nucleus or deposit formed.
    Type: Application
    Filed: August 9, 2002
    Publication date: May 8, 2003
    Inventors: Wolfgang Fritzsche, Andrea Czaki, Johann Michael Koehler, Robert Moeller, Frederik Schut, Louis Oosting, Paris Som Tjwan Tan
  • Patent number: 6558904
    Abstract: The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded substance libraries. To this end, a) a substrate (2) suitable for the first monolayer is provided; b) a microstructured polymer mask (1) having openings is applied to the subtrate (2) at least once in a defined direction.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: May 6, 2003
    Assignee: Clondiag Chip Technologies GmbH
    Inventors: Eugen Ermantraut, Johann Michael Köhler, Torsten Schulz, Klaus Wohlfart, Stefan Wölfl