Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and X are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

Abstract: The present invention provides compounds of formula (I) 1

Abstract: The present invention provides compounds of formula (I) 1

Abstract: The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.

Abstract: The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.

Abstract: A tricycle type vehicle that uses a reciprocating crank system to drive the vehicle is shown. In this design, the operating parts of the vehicle are enclosed by a padded shell that has a soft removable cover. The padded shell ensures that a child has no access to the moving parts while the vehicle is in motion The soft removable covers have different designs, such as animals (horses, lions, etc.), dinosaurs, cartoon characters, or any popular style. The soft covers are also designed to be used a bedding for children, throw rugs or as large stuffed toys. The device also has fenders to prevent contact with the large rear wheels. Finally, sound effects can be added to further enhance the overall operating effect as a toy.

Abstract: A method and apparatus for removing stepper guides that are adhesively bonded to a reticle. A reticle is supported in a generally horizontal position with the stepper guides in contact with heater blocks. Heating elements are placed within the heater blocks and are supplied with a controlled electrical current to maintain the heater blocks at a predetermined temperature. Heat is transferred from the heater blocks to the stepper guides. After a sufficient amount of time, the adhesive begins to flow and the stepper guides may be removed from the reticle. Separate heater blocks are configured to accommodate standard field and wide field guides.