Abstract: Robot includes a propulsion system configured to transport the robot and a controller in communication with the propulsion system. A material handler is carried by the robot and configured for depositing articles into one or more destination containers. The material handler has a tilt tray having sections that are configured for tilting in any number of directions relative to a vertical of the robot. Each section of the tilt tray may include a respective conveyor that moves articles at variable speed.

Abstract: In various embodiments, neuroprotective compositions and uses thereof are provided. In certain embodiments, a method of protecting mammalian neurons from neurotoxins, oxidative stress or protein aggregation, mitochondrial dysfunction, inflammatory gene expression, induced cell death is provided where the method involves contacting the cells, such as neurons, with an effective amount of: a plurality of proteins that are secreted by induced pluripotent stem cells (iPSCs) derived from a healthy mammal and/or from a mammal with a disease, such as neurodegenerative pathology, exemplified by amyotrophic lateral sclerosis (ALS) where said proteins are secreted when said iPSC cells are pluripotent; and/or biologically active fragments of said proteins; and/or biologically active analogs of said proteins.

Abstract: A fluid connection for a vehicle includes a duct extending from a compartment wall of the vehicle. The duct defines a first channel and a second channel each in fluid communication with a climate control system of the vehicle. A container is selectively coupled with the duct and defines a receptacle configured to receive the duct to provide fluid communication between an interior of the container and the climate control system. At least one first aperture and at least one second aperture are each formed on the duct. The at least one first aperture fluidly interposes the interior and the first channel and the at least one second aperture fluidly interposes the interior and the second channel when the container is coupled with the duct.

Abstract: A catheter pump system is disclosed. The catheter pump system can include a shaft assembly and an impeller coupled with a distal portion of the shaft assembly. A motor assembly can impart rotation on the impeller through the shaft assembly, the motor assembly comprising a motor which rotates the shaft assembly. The catheter pump system can include a fluid pathway which conveys fluid proximally during operation of the catheter pump system. A seal can be disposed between the motor assembly and the impeller. The seal can be configured to impede or prevent the fluid from the fluid pathway from entering the motor assembly at least about an outer periphery of the shaft assembly. The seal can comprise an opening through which a portion of the shaft assembly extends.

Abstract: A system and method for aiding in the proper placement of ECG electrodes and other resuscitation parameters. The system includes motion sensors disposed on the ECG electrodes, and a defibrillator control system operable to interpret motion signals from the motions sensors to determine that an electrode is in motion, and thus being handled by rescuer setting up the system for use, and, based on this determination, prompt the rescuer to place the electrode in its intended location on the body of the patient.

Abstract: The present disclosure relates to, inter alia, compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to an epitope of CD137 and agonize CD137, and to use of the compounds in methods for treating, or ameliorating one or more symptoms of, cancer.

Abstract: Provided herein is an antifolate predictive response signature for use in determining the response of a subject suffering from cancer to antifolate therapy. Also provided are methods and compositions for determining proliferation in a sample obtained from a subject suffering from cancer through the use of a proliferation gene signature as well as methods for predicting response of a subject suffering from cancer based on an assessment of proliferation in a sample obtained from the subject.

Abstract: A method for training a fault probability model using warranty claim data includes obtaining, by a processing circuit, a first data set for failed building devices based on warranty claim data associated with the building devices; receiving, by the processing circuit, design change data associated with the building devices and determining a design change date based on the design change data; comparing, by the processing circuit, a manufacturing date for each of the failed building devices with the design change date; removing, by the processing circuit, any building devices from the first data set in response to the manufacturing date preceding the design change date to create an updated first data set; generating, by the processing circuit, a training data set comprising the updated first data set; and training, by the processing circuit, a fault probability model using the training data set to produce a trained model.

Abstract: A package is formed that encapsulates first and second components having respective first and second thickness differing from each other. Each component has lower surface provided with electrical contact pads and an upper surface opposite the lower surface. A volume of molding material encapsulates the first component. The package includes a set redistribution layers including a set of electrically-conductive interconnects surrounded by electrically-insulating material. The redistribution layers are disposed above the upper surface of the first component. The package includes one or more electrically conductive interconnects that pass through the redistribution layers to the lower surface of the first component; The second component is disposes at a location adjacent to the first component. A first portion of the second component is surrounded by the volume of molding material and a second portion of the second component is surrounded by one or more of the redistribution layers.

Abstract: A thermally managed storage system for a vehicle that includes a partition structure that couples with and is expandable in a compartment of the vehicle. The partition structure includes a first wall fixed with the compartment and a plurality of second walls that are each moveable between a retracted position and an extended position. The plurality of second walls forms a space between the first wall and the plurality of second walls in the extended position. A casing is disposed in a space and selectively couples with a climate control system of the vehicle via a fluid connection with the compartment.

Abstract: An electronic device package and method of fabricating such a package includes a first and second components encapsulated in a volume of molding material. A surface of the first component is bonded to a surface of the second component. Upper and lower sets of redistribution lowers that include, respectively, first and second sets of conductive interconnects are formed on opposite sides of the molding material. A through-package interconnect passes through the volume of molding material and has ends that terminate, respectively, within the upper set of redistribution layers and within the lower set of redistribution layers.

Abstract: A golf ball has a generally spherical surface and a plurality of dimples separated by a land area formed on the surface. The plurality of dimples includes a plurality of non-spherical dimples each having a non-axially symmetric plan shape, a varying edge angle, and a geometric centroid of the non-axially symmetric plan shape (GC). Each dimple cross-section of each non-spherical dimple consists of two arcs, each arc extending from a defined point of maximum dimple depth to a point at the land area of the golf ball. Each non-spherical dimple is oriented at an orientation angle, ?, relative to a reference line. The orientation angle ? is dependent on the position of the GC on the surface of the golf ball.

Abstract: A multi-zone media system and method for providing multi-zone media. As a non-limiting example, various aspects of this disclosure provide a system and method that flexibly presents media content (e.g., audio content) to a user as the user moves throughout a premises.

Abstract: A fractional-N phase-locked loop (PLL) that maintains phase coherence for an output signal with a plurality of possible output frequencies. The fractional-N PLL includes an oscillator, a phase detector to receive a reference clock signal and a feedback signal, and a multi-modulus divider coupled in a feedback path between the oscillator and the phase detector. A multi-modulus pattern generator supplies a drive pattern to the multi-modulus divider to achieve a desired change in frequency of the output signal. The multi-modulus pattern generator initiates the drive pattern at a boundary time to cause the output signal to have a substantially repeatable phase when restarting switching from any one of the output frequencies to any other of the output frequencies.

Abstract: A method includes receiving an outgoing data stream and dividing the outgoing data stream to generate multiple electromagnetic signals in multiple channels using a first manifold. The method also includes modifying at least some of the electromagnetic signals in at least some of the channels to generate scrambled electromagnetic signals. The method further includes combining the scrambled electromagnetic signals to generate one or more outgoing scrambled combined electromagnetic signals using a second manifold. In addition, the method includes transmitting the one or more outgoing scrambled combined electromagnetic signals. The outgoing data stream may include an outgoing optical data stream, and a photonic integrated circuit may divide the outgoing optical data stream and produce scrambled optical signals. The photonic integrated circuit may be configured to handle outgoing optical data streams having different protocols and/or different data rates.

Abstract: One variation of a system includes: a cam block mounted to a deck of a scooter and defining cam lobes arranged about a pivot feature and cam heels between the set of cam lobes; a pivot block pivotably coupled to the pivot feature and defining followers riding over the cam lobes; a pair of wheel uprights locating a pair of wheel assemblies; a first lateral link extending between and coupled to the pair of wheel uprights and pivotably coupled to the pivot block; a second lateral link extending between and coupled to the pair of wheel uprights, vertically offset from the first lateral link, and coupled to the pivot block between pair of wheel uprights; and a spring element driving the followers of the pivot block into cam heels to bias the second lateral link toward a neutral position.

Abstract: Systems and methods for presenting calendar information in electronic messages can include a data processing system receiving a request for calendar information for display in an electronic message responsive to the client device accessing the electronic message. The data processing system can identify, using information in the request, the calendar information of the sender of the electronic message and calendar information of the recipient of the electronic message. The data processing system can retrieve the calendar information of the sender of the electronic message and the calendar information of the recipient of the electronic message. The data processing system can automatically generate an image depicting the calendar information of the sender of the electronic message and the calendar information of the recipient of the electronic message, and send instructions to the client device to cause display of the image within the electronic message accessed by the client device.

Abstract: The invention provides methods of preparing 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid. Also provided are compositions and pharmaceutical materials including a purified amount of 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid as well as methods of treating various diseases and conditions using the compositions and pharmaceutical materials.

Abstract: Electronic telecommunication articles are described comprising a layer of fluoropolymer composition comprising: an amorphous fluoropolymer comprising at least 80, 85, or 90% by weight of polymerized units perfluorinated monomers including one or more unsaturated perfluorinated alkyl ethers; and crystalline fluoropolymer; wherein the fluoropolymer composition lacks crosslinks of a chemical curing agent. Also described are methods of making a coated substrate, substrates comprising a fluoropolymer composition, and fluoropolymer compositions.

Abstract: A thermal management system for a vehicle includes a connection interface that is coupled with a compartment of the vehicle and is in fluid communication with a climate control system of the vehicle. A container is movably disposed in the compartment and is in fluid communication with the climate control system via the connection interface. At least one alignment feature is coupled with the compartment and engages at least one sidewall of the container to align the container with the connection interface while the container moves in the compartment.