Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist and a DPP-4 inhibitor.

Abstract: Methods are provided for providing a user with real-time access to supplemental information about named entities that appear within a conversation in a messaging application on a user terminal. Named entities, conversational topics, and sentiments are recognized as the user enters messages into the application. These are provided to a semantic search engine in a server system, that classifies the named entities into one of a variety of domains. Each domain has an associated tool for retrieving detailed supplemental information about the named entity. The server system transmits, to the user terminal, indicia that allow the user terminal to retrieve the supplemental information. Advertising related to a named entity having favorable sentiment also may be transmitted to the user terminal for display. These functions occur without the need for a separate search interface in the messaging application.

Abstract: Some aspects of the present disclosure provide system and method of operation of a driving circuit for a light emitting element in a Time-of-Flight (ToF) camera. A DC-DC converter is configured to emit a constant current, and is coupled in parallel to a first modulation switch configured to connect the driving circuit to ground. The first modulation switch is further configured to alternate connections between the current source and ground at a frequency in a desired range of operation to produce an AC current. In some embodiments, an RC circuit element is coupled to an output electrode of the light emitting element and configured to apply a reverse bias to decrease turn-off time of the light emitting element. In some embodiments, a second modulation switch is coupled to the output electrode and configured to apply the reverse bias across the light emitting element. Other systems and methods are also disclosed.

Abstract: The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long-acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: A hair treatment formulation comprises a plurality of composite nanoparticles in solution. The composite nanoparticles of at least one alternative embodiment are specifically prepared having a first inner polymeric gel layer comprising one or more acidic component, a second inner polymeric gel layer comprising one or more thiolate reactant having a carboxylic group, and an outer polymeric gel layer comprising peptides formed one or more amino acids of hydrolyzed keratin protein. At least one treatment component is embedded in at least one of the first inner polymeric layer, second inner polymeric layer, or the outer polymeric gel layer. Alternative methods of preparing a hair treatment formulation comprising composite nanoparticles is disclosed along with alternative methods of use of the alternative hair treatment formulations comprising a plurality of composite nanoparticles.

Abstract: A device is provided for hanging a frame member against a wall includes a crossbar and first and second vertical arms oriented perpendicular to the crossbar. The crossbar has a longitudinal track and a leveling bubble. The first and second vertical arms each have a linear track that extends along the length, and a marker on the rearward surface thereof. The vertical arms are retained to the crossbar by knuckles having a guide for slideably engaging the linear track of the vertical arms and the first vertical arms are retained perpendicular to the crossbar and are longitudinally moveable perpendicular to the linear edge.

Abstract: A system and method for blade angle position feedback. The system comprises an annular member operatively connected to rotate with a propeller, a sensor fixedly mounted adjacent the annular member and configured for detecting a passage of each singularity as the annular member is rotated and axially displaced and for generating a sensor signal accordingly, the annular member and sensor configured for relative axial displacement between a first relative axial position and a second relative axial position respectively corresponding to the first and the second mode of operation, and a detection unit connected to the sensor for receiving the sensor signal therefrom, determining on the basis of the sensor signal a time interval elapsed between the passage of successive singularities, and computing from the time interval blade angle position.

Abstract: Representative implementations of devices and techniques provide dynamic calibration for imaging devices and systems. A reference pixel is arranged to receive an electrical reference signal and to output a calibration signal. The reference signal may be based on imaging illumination.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: A computer-implemented system and method for obtaining product related information. Information related to a product obtained from a plurality of different sources is transformed into processed product data with a plurality of levels. Callouts and contexts are identified in the processed product data. A product-to-chemical continuum is generated by creating callout-context pathway segments between the plurality of levels of the processed product data based on the callouts and contexts identified. A query request for product information is transformed into a set of context search parameters, which is used to traverse the product-to-chemical continuum through the callout-context pathway segments that span the plurality of levels. The product information that matches the set of context search parameters is extracted from the product-to-chemical continuum. The callout-context pathway segments reduce processing resources and time needed to obtain the product information.

Abstract: A connector includes a cable tray configured to receive and retain a cable in a stable position and couple with a top cap configured to create an electrical connection with the cable as the top cap is manipulated in a predetermined manner while coupled with the cable tray. An upper surface of the cable tray is configured to receive the cable. The cable tray also includes a finger extending beyond the first end for some distance longitudinally. The finger includes a protrusion that protrudes to some extent in a transverse direction so that a cable-accommodating gap is defined between the protrusion and the first end. The protrusion is configured to bear against the cable and retain the cable in the stable position when the cable is inserted between the protrusion and the first end (before, during and/or after an electrical connection is established).

Abstract: A connector includes a cable tray configured to receive and retain a cable in a stable position and couple with a top cap configured to create an electrical connection with the cable as the top cap is manipulated in a predetermined manner while coupled with the cable tray. An upper surface of the cable tray is configured to receive the cable. The cable tray also includes a finger extending beyond the first end for some distance longitudinally. The finger includes a protrusion that protrudes to some extent in a transverse direction so that a cable-accommodating gap is defined between the protrusion and the first end. The protrusion is configured to bear against the cable and retain the cable in the stable position when the cable is inserted between the protrusion and the first end (before, during and/or after an electrical connection is established).

Abstract: Methods, systems, and computer program products determine, for a number of individuals having a common interest, locations relevant to that common interest. Each individual possesses a user terminal that has a location and executes a messaging application. During the course of a messaging conversation, the application transmits search parameters to a central server. The search parameters may be entered manually or determined automatically by analyzing the conversation. The server identifies clusters of locations that satisfy the search parameters in addition to satisfying geographic proximity to the participants in the conversation. The server scores the clusters, and transmits to the user terminal data relating thereto, for integrated display in the messaging application. Relevant advertising may be identified and transmitted for contemporaneous display.

Abstract: Representative implementations of devices and techniques provide adaptive distance estimation for imaging devices and systems. Distance estimation may be based on phase delays in reflected light. Reference phases used to determine phase delay values may be changed for subsequent frame events. Multiple frame events may be selected for some distance calculations based on whether object movement is detected within a predetermined area.

Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug, a poorly aqueous soluble non-ionizable cellulosic polymer, and a poorly aqueous soluble polymeric amphiphilic non-ionizable block copolymer.

Abstract: The present disclosure relates to devices, methods and kits for accelerating the rate of whitening of teeth using an oxidizing agent, a photocatalytic agent, and a portable lightsource.

Abstract: Representative implementations of devices and techniques provide adjustable parameters for imaging devices and systems. Dynamic adjustments to one or more parameters of an imaging component may be performed based on changes to the relative velocity of the imaging component or to the proximity of an object to the imaging component.