Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R4 are as defined herein, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The invention relates to the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia using a SGLT-2 inhibitor. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Abstract: The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.

Abstract: The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a DPP-4 inhibitor and a long-acting insulin. The invention further relates to a DPP-4 inhibitor for subcutaneous or transdermal use.

Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: Example methods and apparatus to display mobile device contexts are disclosed. An example method includes displaying a first context in a user interface of a mobile device based on first device platform information, the first context including a first arrangement of information, graphics, and application icons that are associated with the first device platform information, determining that second device platform information received after the first device platform information corresponds to a second context, the second context being different from the first context and including a second arrangement of information, graphics, and applications that are associated with the second device platform information, and displaying the second context in the user interface replacing the first context without prompting a user of the mobile device.

Abstract: According to embodiments described in the specification, a method, system and apparatus for associating vendor data with keywords in a wireless mobile communication device are provided. The method comprises: receiving an auction request comprising a keyword identifying a required offering and one or more parameters associated with the keyword, each parameter defining a required attribute of the offering; retrieving a plurality of vendor bids, each bid comprising one or more vendor parameters associated with the keyword, each vendor parameter defining an attribute of a vendor offering corresponding to the required offering; determining whether each of the vendor bids satisfies the required attributes defined by the parameters; and when the determination is affirmative for at least one vendor bid, transmitting vendor data for a vendor associated with the at least one vendor bid to the mobile electronic device for storage at the mobile electronic device in association with the keyword.

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R4 are as defined herein, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Abstract: Illustrative apparatuses and methods for electrostatic discharge protection are described in which the frequency of a voltage received at a first circuit node is filtered to generate a filtered voltage, one or more control signals are generated having either a first voltage or a second voltage depending upon the value of the filtered voltage, and the first circuit node is selectively connected with a second circuit node depending upon the value of the one or more control signals.

Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.

Abstract: The present disclosure described herein relates to a system and method for distributing messages to electronic devices. The method comprises: identifying a first device that is in communication with a second device; identifying an advertisement that matches at least one attribute associated with at least one of the first and second devices; transmitting the advertisement to the first device; and upon receipt of a notification of approval of the advertisement, transmitting the advertisement to the second device.

Abstract: The present invention relates to combinations of DPP-4 inhibitors with GPR119 agonists, as well as to the use of these combinations for treating and/or preventing metabolic diseases, particularly diabetes (especially type 2 diabetes mellitus) and conditions related thereto.

Abstract: The present disclosure related to a system, method and device for distributing messages to electronic devices is provided. The method comprises: identifying two devices that have been communicating with each other and that have at least one common attribute; identifying an advertisement campaign that matches the at least one common attribute; and transmitting a set of advertisements relating to the advertisement campaign to the two devices.

Abstract: Addresses are searched in an address book on a communication device in response to various context information. A category is defined from a keyword. A context is determined. The address book is searched using the keywords and/or category and or/context to locate matching contacts. Matching contacts may be presented in a user interface, e.g., in accordance with presentation rules responsive to the context. The method may further look-up (and present) one or more addresses (e.g. advertisements) matching the keyword and/or category and/or context from a remote service. The context may be data defined from any of time, day of the week, communication device location, communication device velocity, device profile and category of a matching contact. Device profile may be determined using profile determining rules and contextual data. The method may periodically collect contextual data and define a profile determining rule in response to a pattern in the collected data.