Abstract: The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Abstract: A golf car scorecard holder assembly, wherein the assembly includes a baseplate having a topside face, an underside face and a clip attachment portion. The assembly additionally includes a retention clip pivotally connectable to the clip attachment portion of the baseplate such that a pivot axis of the retention clip relative to the baseplate is adjacent the underside face of the baseplate. The assembly further includes a biasing device disposed between a backside of the retention clip and the topside face of the baseplate, the biasing device structured and operable to exert a closing force on the retention clip to bias the retention clip to a Closed position.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: Wearable compression systems, which may comprise one or more or a plurality of actuator(s) embedded within a textile structure and may be configured to provide a compression function to a therapy target of an individual. Wearable compression systems may comprise a circuit or the like. Methods of operating a wearable compression system. Methods of designing (e.g., automatically designing) wearable compression systems. Methods of designing may comprise receiving a set of measurements, generating default dimensions, default number of actuators, and/or default actuator locations for a wearable compression system and/or a graphical representation of same, optionally modifying default dimensions, default number of actuators, and/or default actuator locations, updating the wearable compression system and/or graphical representation of same, and generating an instruction file. Methods of treating edema or symptoms of edema.

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

Abstract: Disclosed are a container assembly and a food processing system (20) comprising thereof. The container assembly includes a sealable body including a chamber (32), a chamber opening (56) formed in the sealable body, and a vacuum sealing assembly (52) mounted to the sealable body adjacent the chamber opening (56). The vacuum sealing assembly (52) includes a needle valve (60) having a needle valve opening formed therein. The needle valve (60) is movable relative to the chamber opening (56) such that the needle valve opening is movable into and out of the chamber (32). A biasing mechanism (74) is operably coupled to the needle valve (60) to move the needle valve opening out of the chamber (32).

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: A housing assembly for a fluid sensor assembly includes a housing having a first and second sensing volumes. A fluid port attached to the housing has a porous membrane covering first and second fluid apertures. The first sensing volume included a vertically-oriented waveguide and is fluidly coupled to an exterior of the housing through the first fluid aperture, where the first aperture port has an area smaller than an area of a cross section of the waveguide. The second sensing volume is coupled to the exterior of the housing through the second fluid aperture, the second fluid aperture having an area larger than a cross section of the second sensing volume. While the first sensing volume and the second sensing volume are both in fluid communication with an exterior of the housing, the fluid port and porous membrane internally isolate the first sensing volume from the second sensing volume.

Abstract: A stabilized luggage article is disclosed. In one practice, the luggage article comprises a plurality of swiveling wheel assemblies, each assembly comprising one or more wheels having a horizontal axis of rotation and mounted to a pivot member, such as a pivot post that has a vertical axis of wheel rotation; the vertical axis of rotation is laterally spaced from the horizontal axis of rotation and is projected outwardly toward the front wall of the luggage but not beyond it, the pivot post extending downwardly at least to the level of the horizontal axis of wheel rotation, preferably beyond it for further increased stability.

Abstract: Disclosed is a physical unclonable function generator circuit and method.

Abstract: A container (32) includes a sealable body including a chamber (42), at least one opening formed in the sealable body, and a vacuum sealing assembly (52) mounted to the sealable body adjacent at least one opening. The vacuum sealing assembly (52) includes a valve (60) and a mechanism (70) moveable between a first position that maintains the valve (60) in a sealing engagement with at least one opening and a second position that removes the valve (60) from the sealing engagement or exposes the valve (60) for removal from the sealing engagement.

Abstract: This invention discloses novel systems and methods for providing visual confirmation that a passenger has a valid ticket and has previously paid for additional items such as luggage, suitcase, briefcase, bicycle, musical instrument, wheelchair, car, vehicle, motorcycle, automobile (in the case of, for example, a ferry). The visual validation display object allows tickets and additional items to be easily and quickly confirmed.

Abstract: A computer system is provided that is programmed to select feature sets from a large number of features. Features for a set are selected based on metagradient information returned from a machine learning process that has been performed on an earlier selected feature set. The process can iterate until a selected feature set converges or otherwise meets or exceeds a given threshold.

Abstract: The present disclosure is generally directed to an attachment mechanism suitable for attaching a module to an object, e.g. to a portion of a drug delivery device. Further, the disclosure is directed to an electronic system, e.g. an electronic add-on module, which is configured to be, e.g. releasably, attached to a drug delivery device as well as an assembly including the electronic add-on module as well as the drug delivery device. The attachment mechanism may include at least one attachment member with a longitudinal axis, an adhesive distal end surface and an opposite adhesive proximal end surface.

Abstract: Embodiments of the disclosed subject matter provide a device that includes an organic light emitting device (OLED), and a drive circuit to control the operation of the OLED, comprising a response time accelerator thin film transistor (TFT) configured to short or reverse bias the OLED for a predetermined period of time during a frame time. Other embodiments include an OLED having a plurality of sub-pixels, where one or more of sub-pixels configured to emit light of at least a first color comprises a first emissive area and a second emissive area that are independently controllable, where the first emissive area is larger than the second emissive area. The controller is configured to control the second emissive area to have (i) a higher brightness, and/or (ii) a higher current density than the first emissive area for a first sub-pixel luminance level that is less than a maximum luminance.

Abstract: Disclosed is a physical unclonable function generator circuit and method. In one embodiment, a physical unclonable function (PUF) generator comprising: a plurality of PUF cells, wherein each of the plurality of PUF cells comprises a first MOS transistor and a second MOS transistor, wherein terminal S of the first MOS transistor is connected to terminal D of the second MOS transistor at a dynamic node, terminal D of the first MOS transistor is coupled to a first bus and terminal G of the first NMOS transistor is coupled to a second bus, and terminals S and G of the second NMOS transistor are coupled to ground; a plurality of dynamic flip-flop (DFF) circuits wherein each of the plurality of DFF circuits is coupled to each of the plurality of PUF cells respectively; a population count circuit coupled to the plurality of DFF circuits; and an evaluation logic circuit having an input coupled to the population count circuit and an output coupled to the plurality of DFF circuits.

Abstract: Examples determine a reference complex impedance of a reference cell over a range of one or more frequencies. Examples determine an in situ complex impedance, over the range of one or more frequencies, of each of one or more cells of a battery with measurement equipment, the battery and the measurement equipment in situ in an end use system, the measurement equipment including sense conductor(s) coupled to each cell and force conductor(s) coupled to the battery. For each cell of the battery, examples determine a model complex impedance that, when in combination with the impedance of the cell, accounts at least in part for a difference between the in situ impedance of the cell and the reference impedance, the examples then adjust the in situ impedance as a function of the model impedance. Examples control operation of the battery based on the adjusted impedance of each of the particular cells.

Abstract: Liquid chromatography systems described herein are smaller in size and with a reduced extra-column volume due to direct connection of a liquid chromatography column and/or detector to an injector valve and due to eliminating the need for a column oven by relying on heating of the liquid chromatography column and detector by a preheater. The size of the liquid chromatography systems are enough that the liquid chromatography systems may be deployed adjacent to automated sample preparation robotics, adjacent to a process stream, or adjacent to the inlet of a mass spectrometer. In addition, the extra-column volume of the liquid chromatography systems may be reduced by eliminating many of the connection tubes and by situating components of the liquid chromatography system in closer proximity.

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

Abstract: A hierarchical network enables access for a stacked memory system including or more memory dies that each include multiple memory tiles. The processor die includes multiple processing tiles that are stacked with the one or more memory die. The memory tiles that are vertically aligned with a processing tile are directly coupled to the processing tile and comprise the local memory block for the processing tile. The hierarchical network provides access paths for each processing tile to access the processing tile's local memory block, the local memory block coupled to a different processing tile within the same processing die, memory tiles in a different die stack, and memory tiles in a different device. The ratio of memory bandwidth (byte) to floating-point operation (B:F) may improve 50× for accessing the local memory block compared with conventional memory. Additionally, the energy consumed to transfer each bit may be reduced by 10×.