Abstract: The present disclosure provides a medical optical fiber comprising a renewable distal end. The renewable distal end comprising several detachable segments where the detachable segments can be selectively and/or automatically detached to renew the distal most tip of the optical fiber.

Abstract: An electronic add-on module configured for releasable attachment to a drug delivery device is described. The electronic add-on module includes at least a body configured to be releasably attached to the device housing, a coupler configured to be releasably attached to the device dial grip, and a dial configured to be axially displaceable with respect to the coupler. The electronic add-on module further includes a tube which is configured to be permanently rotationally constrained to the body and configured to be axially displaceable relative to the body wherein the dial is configured to be rotatable relative to the tube at least in a dialing mode.

Abstract: A method includes obtaining multiple video frames. The method also includes determining whether a bi-directional optical flow between the multiple video frames satisfies an image quality criterion for bi-directional consistency. The method further includes identifying a non-linear curve based on pixel coordinate values from at least two of the video frames. The at least two video frames include first and second video frames. The method also includes generating interpolated video frames between the first and second video frames by applying non-linear interpolation based on the non-linear curve. In addition, the method includes outputting the interpolated video frames for presentation.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: The present disclosure describes 4?-fluoromethyl nucleosides for treating viral infections, including Dengue.

Abstract: A vehicle, wherein the vehicle comprises a chassis, a plurality of wheels operatively connected to the chassis, a passenger compartment supported by the chassis, and at least one multi-use accessory retention loop disposed on the vehicle and structured and operable to retain a passenger personal item.

Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of a vapor deposition coated frit together with an uncoated frit in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having a single coated frit within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.

Abstract: Embodiments of the disclosed subject matter provide a device that includes an organic light emitting device (OLED), and a drive circuit to control the operation of the OLED, comprising a response time accelerator thin film transistor (TFT) configured to short or reverse bias the OLED for a predetermined period of time during a frame time. Other embodiments include an OLED having a plurality of sub-pixels, where one or more of sub-pixels configured to emit light of at least a first color comprises a first emissive area and a second emissive area that are independently controllable, where the first emissive area is larger than the second emissive area. The controller is configured to control the second emissive area to have (i) a higher brightness, and/or (ii) a higher current density than the first emissive area for a first sub-pixel luminance level that is less than a maximum luminance.

Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.

Abstract: Disclosed is a physical unclonable function generator circuit and method.

Abstract: A compressor system can include a lubricant injection system useful to supply lubricant to an airend. The compressor system can include a variable lubricant flow valve which can be regulated by a controller on the basis of operating conditions of the compressor system. In one form the compressor system also includes an oil separator and/or an oil cooler with or without a thermal control valve. The controller can have one or more modes of operation, including a mode in which the controller regulates the flow of lubricant to the airend to increase an internal flow area of the valve when the airend is operated at an unloaded or loaded condition. In some forms the controller can regulate the lubricant flow valve and/or the thermal control valve and/or the lubricant cooler.

Abstract: A system and a method for providing rewards to a user for in-game achievements across multiple third-party game platforms are disclosed. The system includes a user account module for storing user profiles, an SDK module integrated with each game platform for defining in-game achievements and associated rewards, and an API module for receiving information about these achievements. The API module generates an achievement signal when a user completes an achievement. A processing module receives this signal, determines the corresponding rewards using the SDK module, and adds these rewards to the user's profile via the user account module, providing a personalized gaming experience across multiple platforms.

Abstract: Embodiments of the present disclosure relate to application partitioning for locality in a stacked memory system. In an embodiment, one or more memory dies are stacked on the processor die. The processor die includes multiple processing tiles and each memory die includes multiple memory tiles. Vertically aligned memory tiles are directly coupled to and comprise the local memory block for a corresponding processing tile. An application program that operates on dense multi-dimensional arrays (matrices) may partition the dense arrays into sub-arrays associated with program tiles. Each program tile is executed by a processing tile using the processing tile's local memory block to process the associated sub-array. Data associated with each sub-array is stored in a local memory block and the processing tile corresponding to the local memory block executes the program tile to process the sub-array data.

Abstract: The exemplary embodiments may provide a collective insulating sleeve for a plurality of chromatography columns or may provide separate insulating sleeve for each of the chromatography columns in a plurality. As a result, column ovens are not needed, and pre-heaters may not be required for each chromatography column in some exemplary embodiments. Thus, parallel column arrangements in the exemplary embodiments may be more compact than conventional arrangements.

Abstract: Liquid chromatography systems described herein are smaller in size and with a reduced extra-column volume due to direct connection of a liquid chromatography column and/or detector to an injector valve and due to eliminating the need for a column oven by relying on heating of the liquid chromatography column and detector by a preheater. The size of the liquid chromatography systems are enough that the liquid chromatography systems may be deployed adjacent to automated sample preparation robotics, adjacent to a process stream, or adjacent to the inlet of a mass spectrometer. In addition, the extra-column volume of the liquid chromatography systems may be reduced by eliminating many of the connection tubes and by situating components of the liquid chromatography system in closer proximity.

Abstract: A home occupancy status and information system may be used to track information about human and animal occupants within a structure and provide information to first responders in the event of an emergency. A rescue beacon may be positioned near an entrance to a home, and when an audible alarm or alarm signal is detected by the beacon it will provide visual alerts and/or audible alerts to attract the attention of a first responder, and will provide information on occupants in the home, such as a number of pets, a number of humans, and other information. A rescue device may also be carried by each pet or other occupant in the house, which may be activated by a wireless signal from a rescue beacon, or by a detected alarm audio/signal. When activated, the rescue device will provide audible and/or visual alerts to aid first responders in locating the occupant.

Abstract: A computer system is provided that is programmed to select feature sets from a large number of features. Features for a set are selected based on metagradient information returned from a machine learning process that has been performed on an earlier selected feature set. The process can iterate until a selected feature set converges or otherwise meets or exceeds a given threshold.

Abstract: A system and a method for managing an avatar across multiple three-dimensional (3D) rendering platforms are disclosed. The system includes a content database, a content delivery module, a Software Development Kit (SDK) module, and an Application Programming Interface (API) module. The content database stores a 3D avatar model and associated first assets. The SDK module integrates with an in-engine avatar customization module of each 3D rendering platform and allows users to use these assets to customize their avatar during runtime. The API module receives requests for avatar and asset data. The content delivery module fetches requested avatar data and assets in response to requests received at the API module and delivers the requests to the SDK module. Additionally, the content delivery module fetches, stores, and manages second assets used for avatar customization from the SDK module.

Abstract: Disclosed is a physical unclonable function generator circuit and testing method. In one embodiment, a physical unclonable function (PUF) generator includes: a PUF cell array comprising a plurality of bit cells configured in a plurality of columns and at least one row, wherein each of the plurality of columns is coupled to at least two pre-discharge transistors, and each of the plurality of bit cells comprises at least one enable transistor, at least two access transistors, and at least two storage nodes, and a PUF control circuit coupled to the PUF cell array, wherein the PUF control circuit is configured to access the plurality of bit cells to pre-charge the at least two storage nodes with substantially the same voltages allowing each of the plurality of bit cell having a first metastable logical state; to determine a second logical state; and based on the determined second logical states of the plurality of bit cells, to generate a PUF signature.

Abstract: A method for operating an aggregated web service to display location-based items and services and allow for their remote purchase and pick-up or delivery. Algorithms provided to vendors allow for automated pricing adjustments to encourage purchase in competitive geographical locations.