Abstract: The present disclosure relates to electronic devices and methods of manufacturing electronic devices. A method of manufacturing a dissolvable electronic device includes forming a dissolvable sheet; applying a self-sintering agent to the dissolvable sheet to form a substrate; and depositing electrically conductive ink onto the substrate in a trace. A method of manufacturing a meltable electronic device includes mixing a conductive material with a melted wax to form a conductive wax mixture in liquid form; molding the conductive wax mixture; and solidifying the conductive wax mixture to obtain the meltable electronic device. A method of manufacturing an edible electronic device includes cutting a layer of conductive material to form a pattern that defines a circuit; applying the layer of conductive material to an edible medium, wherein the edible medium is in liquid or semi-solid form; and solidifying the edible medium to obtain the edible electronic device.

Abstract: In various examples, surface profile estimation and bump detection may be performed based on a three-dimensional (3D) point cloud. The 3D point cloud may be filtered in view of a portion of an environment including drivable free-space, and within a threshold height to factor out other objects or obstacles other than a driving surface and protuberances thereon. The 3D point cloud may be analyzed—e.g., using a sliding window of bounding shapes along a longitudinal or other heading direction—to determine one-dimensional (1D) signal profiles corresponding to heights along the driving surface. The profile itself may be used by a vehicle—e.g., an autonomous or semi-autonomous vehicle—to help in navigating the environment, and/or the profile may be used to detect bumps, humps, and/or other protuberances along the driving surface, in addition to a location, orientation, and geometry thereof.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: Methods and systems provide for predicting and constraining kinematic trajectories of an object within an environment. In one embodiment, the system obtains sensor data from one or more sensor data streams; predicts, via an inertial tracking model, a trajectory of an object in an environment in a continuous fashion using the sensor data; retrieves environmental data consisting of a number of environmental constraints relating to the environment; generating, via a reinforcement learning (RL) agent, a number of corrections to the trajectory of the object based on the environmental constraints within the environmental data; and provides real-time tracking and navigation of the object in the environment based on the continuously predicted trajectory and the corrections to the predicted trajectory.

Abstract: A firearm safety mechanism assembly is provided. The firearm safety mechanism assembly includes a firearm with a receiver, a trigger guard coupled to the firearm, and a housing pin. The firearm safety mechanism assembly includes a trigger safety mechanism. The trigger safety mechanism includes a plate, a rod extending from the plate, a trigger coupled to the rod, and a lever nested within the trigger. The lever includes a lever first end and a lever second end, where the lever rotates between a first position and a second position. In the first position, the lever first end abuts a housing pin.

Abstract: Systems, devices and methods for implanting neuromodulation systems and, in some cases, spinal fixation systems using a single surgical incision and placing the system components with direct visual and physical access through an open access. Implantable pulse generators of the neuromodulation systems include lead receptacles and, in some cases, the leads may bifurcate into two leads at a proximal side of the leads. Anchors are provided that are capable of anchoring a body of a neuromodulation lead to the rod of a spinal fixation system and/or engaging bone.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open direct visual and/or physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure may be performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open direct visual and/or physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure may be performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: Detection of mechanical coupling slippage in rotary encoder systems is provided where position data samples are obtained from a rotary encoder coupled to rotating element and angular acceleration data is determined based on the position data samples. At least two acceleration peaks are detected in the angular acceleration data, including at least one negative acceleration peak and at least one positive acceleration peak. Slippage occurrence of the mechanical coupling are detected when an interval between a negative acceleration peak and a positive acceleration peak of the at least two acceleration peaks is less than a first time period. If at least a threshold number of slippage occurrences are detected within a second time period, a mechanical coupling error signal is generated.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: Detection of mechanical coupling slippage in rotary encoder systems is provided where position data samples are obtained from a rotary encoder coupled to rotating element and angular acceleration data is determined based on the position data samples. At least two acceleration peaks are detected in the angular acceleration data, including at least one negative acceleration peak and at least one positive acceleration peak. Slippage occurrence of the mechanical coupling are detected when an interval between a negative acceleration peak and a positive acceleration peak of the at least two acceleration peaks is less than a first time period. If at least a threshold number of slippage occurrences are detected within a second time period, a mechanical coupling error signal is generated.

Abstract: The present invention provides a lead template for optimal lead placement and spacing during a surgical method and procedure for implantation of a neuromodulation system at a spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open direct visual and/or physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels include at least one dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the low-profile pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention discloses a system and method for providing an alert when an interesting segment is imminent during the delivery of a digital content such as, for example, the beginning of a play during a football game, to direct the focus of one or more viewers towards the digital content. The present invention is further configured to embed a commercial message in conjunction with the alert on directing the focus of the viewers. The alerts and commercial messages are inserted by the use of industry standard tags such as those defined by Society of Cable Telecommunications Engineers (SCTE) standards SCTE 35 and SCTE 104. The tags are subsequently replaced by the required alert and commercial message media files at some point in the delivery path of the digital content. The system is adapted to activate the alert either manually or automatically.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open direct visual and/or physical access to an identified spinal treatment site that comprises both targeted vertebral and spinal levels to be treated, wherein the spinal levels comprise at least one dorsal root ganglion. A spinal treatment procedure may be performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrical lead(s) on the at least one dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Electrical stimulation may be generated with the pulse generator through the electrical leads to the at least one dorsal root ganglion during and/or after the closure of the identified spinal treatment site.

Abstract: The present invention provides a single surgical method, procedure and/or system that creates open visual and physical access to an identified spinal treatment site that initially comprises spinal levels to be treated, wherein the spinal levels comprise at least one targeted dorsal root ganglion. A spinal treatment procedure is performed generally in combination with implantation of a neuromodulation system that may comprise placement of electrodes located on leads, the electrodes placed on separate ones of the at least one targeted dorsal root ganglion, wherein each lead is in operative connection with a pulse generator that may also be implanted during the surgical method. Placement of each electrode is facilitated by direct visual and/or direct physical access to the targeted dorsal root ganglion.