Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-Catenin-related diseases such as adenomatous polyposis of the colon, colorectal cancer, basal cell carcinoma, breast cancer, kidney cancer, Wilms tumors, medulloblastoma, ovarian cancer, adrenocortical tumors, gastric cancer, liver cancer, melanoma, pancreatic cancers, prostate cancer, renal cancer, ectopic teeth and taste papillae, skin cancer, pilomatrixoma, anaplastic thyroid carcinoma, and uterine carcinosarcoma, oligodontia, osteoporosis, ageing, degenerative diseases, bedsores, chronic wounds and impaired wound healing, and similar and related diseases, using a therapeutically effective amount of a RNAi agent to Beta-Catenin.

Abstract: A current carrying system for use in transporting electrical current between a plurality of electrical devices is provided. The current carrying system includes a busbar having a first axial end, a second axial end, an electrically conductive shaft extending from the first axial end to the second axial end, and at least one cooling feature defined in at least a portion of the electrically conductive shaft. The current carrying system also includes a casing that defines a busbar channel configured to receive the busbar such that the casing at least partially circumscribes the busbar. The current carrying system also includes an air vent defined by the at least one cooling feature and the casing, wherein the air vent is in flow communication with ambient air, and the cooling feature is configured to facilitate a flow of air from the ambient air through the air vent.

Abstract: Methods and materials for forming in-situ features in a ceramic matrix composite component are described. The method of forming a ceramic matrix composite component with cooling features, comprises forming a preform tape, laying up said preform tape to a desired shape, placing a high-temperature resistant fugitive material insert of preselected geometry in the preform tape of the desired shape, compacting the preform tape of the desired shape, burning out the preform tape of the desired shape, melt infiltrating the desired shape, removing the high-temperature resistant insert to form the cooling features during one of the burning out or the melt infiltrating or following the burning out or the melt infiltrating.

Abstract: Calendar management devices and systems are disclosed that are configured with hardware to generate a calendar object and a calendar share identifier associated with the calendar object, and to cause the calendar share identifier to be provided to each of a plurality of calendar users. User input is received indicating a new event associated with the calendar object, and in response to the user input, the device(s) are configured to determine an authorization level of the new event based on the user input, generate a calendar event object comprising the authorization level, and automatically send a publication request to a remote server over a network, wherein said sending the publication request directs the remote server to determine a subset of the plurality of calendar users based on the authorization level and to send the event object to each of the subset of the plurality of calendar users.

Abstract: A testing machine for testing a test specimen includes an actuator assembly configured to be coupled to the test specimen; and a computing device configured to control the actuator assembly, the computing device including a graphical user interface that renders at least a visual representation or a simulated visual representation of at least a parameter of the component or the component changing in accordance with changes of the actual corresponding component on the testing machine.

Abstract: Systems and methods for detecting biometrics using microwave radar sensor modules are disclosed. Integrated microwave sensor modules can include a transmitter unit configured to generate at least one continuous wave transmit signal based upon at least one frequency control signal, a receiver unit configured to utilize a cancellation path to cancel contributions to a return signal based upon at least one cancellation path control signal, and a microcontroller unit that includes a processor, a memory containing a microcontroller application, where the microcontroller application configures the processor to generate at least one frequency control signal to generate least one CW transmit signal having a plurality of frequencies, generate at least one cancellation path control signal to automatically adjust the cancellation path in real time, receive at least one demodulated signal, digitize the at least one demodulated signal, and update the at least one frequency control and cancellation path control signals.

Abstract: A method of mitigating filter inconsistency of a heading estimate in an inertial navigation system is provided.

Abstract: One variation of a method—for controlling a breathing mask comprising a flow control module configured to mate to nostrils of a user and comprising an actuator configured to adjust obstruction to airflow out of the flow control module—includes: accessing a wake alarm time; accessing a sleep delay duration; at a first time, receiving an indicator that the user is preparing for sleep; in response to receiving the indicator, triggering the actuator to transition from a minimum-restriction position toward a maximum-restriction position at a second time succeeding the first time by the sleep delay duration, the actuator minimally obstructing airflow out of outlet port in the minimum-restriction position and maximally obstructing airflow out of outlet port in the maximally-restriction position; and, prior to the wake alarm time, triggering the actuator to transition back to the minimum-restriction position.

Abstract: An apparatus and method for feeding bees is disclosed. The apparatus comprises a fluid tray member, a sheet, and a regulating valve. The fluid tray member is configured to hold a fluid for feeding the bees. The sheet is detachably attached on the fluid tray member via a magnetic strip. The regulating valve attached to the sheet is configured to maintain the level of the fluid. The regulating valve is attached to the sheet via a fastener. The sheet further comprises an inlet tube, a plurality of cavities, and a handle enable a user to position the apparatus to a desired location. The fluid is received via the inlet tube into the fluid tray member. The sheet provides a flat surface around the cavities to support each of the bees while feeding the fluid.

Abstract: A method for mapping SCIM resources to LDAP entries is provided. An LDAP Directory Information Tree (DIT), including a plurality of LDAP DIT entries that describe LDAP containers, users and groups, is provided. Each LDAP DIT entry includes a Distinguished Name and a plurality of LDAP attribute-value pairs, each of which include an attribute name and one or more attribute values. A SCIM directory, including a plurality of SCIM resource entries, is also provided. Each SCIM resource entry includes a plurality of SCIM attributes, each of which includes a name and one or more values. The plurality of SCIM resource entries are converted to corresponding LDAP DIT entries, and, for each SCIM resource entry that has a SCIM CMVA, the SCIM CMVA is mapped to a plurality of LDAP attributes in the corresponding LDAP DIT entry using LDAP attribute subtypes.

Abstract: Executable memory space is protected by receiving, from a process, a request to configure a portion of memory with a memory protection attribute that allows the process to perform at least one memory operation on the portion of the memory. Thereafter, the request is responded to with a grant, configuring the portion of memory with a different memory protection attribute than the requested memory protection attribute. The different memory protection attribute restricting the at least one memory operation from being performed by the process on the portion of the memory. In addition, it is detected when the process attempts, in accordance with the grant, the at least one memory operation at the configured portion of memory. Related systems and articles of manufacture, including computer program products, are also disclosed.

Abstract: A nozzle assembly is provided which is, in part, formed of a low coefficient of thermal expansion material. The assembly includes a nozzle fairing formed of the low coefficient of thermal expansion material and includes a metallic strut extending radially through the nozzle fairing. Load is transferred from the nozzle fairing to a static structure in either of two ways: first, the strut may receive the load directly and/or second, load may be transferred from the nozzle fairing to at least one of the inner and outer support rings. Further, the nozzle fairing and strut may allow for internal airflow for cooling.

Abstract: Systems and methods for inertial reference system alignment are provided. In certain embodiments, a system comprises an inertial reference system, the inertial reference system providing motion measurements; and a processing system coupled to receive the motion measurements from the inertial reference system. Further, the processing system is configured to execute instructions that direct the processing system to identify one or more frequencies in the spectrum of the motion measurements that are associated with vibrations; attenuate the motion measurements at the one or more frequencies; and use the attenuated measurements to aid in the production of navigation information.

Abstract: A method of mitigating filter inconsistency of a heading estimate in an inertial navigation system is provided.

Abstract: A testing machine for testing a test specimen includes an actuator assembly configured to be coupled to the test specimen; and a computing device configured to control the actuator assembly, the computing device including a graphical user interface that renders at least a visual representation or a simulated visual representation of at least a parameter of the component or the component changing in accordance with changes of the actual corresponding component on the testing machine.

Abstract: A computer-implemented method executed by one or more computer servers includes receiving a notification from a communication device, determining whether one or more other communication devices are within a stationary geofence, and in response to the notification, sending an emergency alert to the other communication devices determined to be within the stationary geofence. The computer-implemented method may further include receiving an acknowledgement of the emergency alert from at least one of the other communication devices determined to be within the stationary geofence and/or sending data indicating an approximate location of the communication device and an associated tolerance of the approximate location. Other example computer-implemented methods, communication devices including software applications, and systems are also disclosed.

Abstract: Embodiments are directed to securing data in the cloud, securely encrypting data that is to be stored in the cloud and to securely decrypting data accessed from the cloud. In one scenario, an instantiated trust service receives information indicating that a trust server is to be instantiated. The trust service instantiates the trust server, which is configured to store key references and encrypted keys. The trust service receives the public key portion of a digital certificate for each publisher and subscriber that is to have access to various specified portions of encrypted data. A data access policy is then defined that specifies which encrypted data portions can be accessed by which subscribers.

Abstract: A nacelle is configured to be coupled to an underside of a wing and forms a clearance space between the nacelle and a leading edge slat of the wing. A portion of an outlet cowling moves longitudinally aft when a reverse thrust configuration is activated and the leading edge slat is deployed toward the nacelle. The outlet cowling also includes another portion located adjacent to the leading edge slat that does not move when the reverse thrust configuration is activated and thus maintains its clearance space from the leading edge slat.

Abstract: A system that reduces crosstalk and return loss within electrical communication connectors includes at least two compensating capacitors connected in series that compensate each offending capacitor. An additional inductive component that is connected between two compensating capacitors so that the adjustable inductance of the inductive component can be varied to modify the capacitive coupling effect achieved by the compensating capacitors as a function of frequency. A shape-neutral structure containing two compensating capacitors and one series inductive component in between is positioned so that each compensating capacitor is juxtaposed parallel to the offending capacitor. There is no direct contact between the shape-neutral structure and the transmission lines, and the shape-neutral structure does not change the shape of PCB traces and reduces both crosstalk and return loss.

Abstract: In some embodiments, apparatuses and methods are provided herein useful for reusable containers and item delivery using reusable containers. In several embodiments, the reusable containers described herein include removable divider walls that can be used to selectively divide an interior of the container into multiple smaller portions. By a further approach, the container and divider walls can have cooperating components to mount the divider wall to the container. In some embodiments, the reusable containers described herein can also include bag handle holding features so that bags placed therein are prevented from spilling contents during transport.