Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: A stacked processor-plus-memory device includes a processing die with an array of processing elements of an artificial neural network. Each processing element multiplies a first operand—e.g. a weight—by a second operand to produce a partial result to a subsequent processing element. To prepare for these computations, a sequencer loads the weights into the processing elements as a sequence of operands that step through the processing elements, each operand stored in the corresponding processing element. The operands can be sequenced directly from memory to the processing elements or can be stored first in cache. The processing elements include streaming logic that disregards interruptions in the stream of operands.

Abstract: Apparatus and methods for measuring backlash of a drive train of an equipment unit. The drive train may comprise an input member operatively connected with an actuator and an output member operatively connected with a work portion of the equipment unit. An example apparatus may include a sensor operable to facilitate operational measurements indicative of an operational parameter associated with the drive train, and a processing device operable to cause the actuator to move the input member until the output member moves, record the operational measurements while the actuator moves the input member, and determine a backlash of the drive train by determining a difference between the operational measurements when the input member starts to move and the operational measurements when the output member starts to move.

Abstract: Systems and methods provide real-time shipping optimization recommendations for reducing the cost of shipping freight units in a shipment. System comprises a measurement system in communication with a computer system that comprises a client computer device in communication with a host computer system. The measurement system comprises multiple sensing devices to determine weight, dimensions, and other shipping parameters of the freight units in the shipment. The computer system computes a current shipping cost and density based on the shipping parameters. The computer system determines shipping recommendations including recommended adjustments to the shipping parameters that reduce the current shipping cost. The shipping recommendations are transmitted to the client computer device prior to loading the shipment onto a carrier vehicle for the shipment.

Abstract: Row hammer is mitigated by issuing, to a memory device, mitigation operation (MOP) commands in order to cause the refresh of rows at a specified vicinity of a suspected aggressor row. These mitigation operation commands are each associated with respective row addresses that indicate the suspected aggressor row and an indicator of which neighbor row in the vicinity of the suspected aggressor row is to be refreshed. The mitigation operation commands are issued in response to a fixed number of activate commands. The suspected aggressor row is selected by randomly choosing, with equal probability, one of the N previous activate commands to supply its associated row address as the suspected aggressor row address. The neighbor row may be selected randomly with a probability that diminishes inversely with the distance between the suspected aggressor row and the neighbor row.

Abstract: Techniques are described for controlling data and resource access. For example, methods and systems can facilitate controlled token distribution across systems and token processing in a manner so as to limit access to and to protect data that includes access codes.

Abstract: Provided is a magnetoresistive random-access memory (MRAM) cell. The MRAM cell comprises a top contact, a hard mask layer below the top contact, and a magnetic tunnel junction (MTJ) below the hard mask layer. The MRAM cell further comprises a diffusion barrier below the MTJ, a bottom contact below the diffusion barrier, and a magnetic liner arranged around the bottom contact.

Abstract: Facility layouts and configurations for an automated crop production system for controlled environment agriculture. In particular implementations, the core of the facility comprises a controlled growth environment and a central processing system. The controlled growth environment includes systems for exposing crops housed in modules, such as grow towers, to controlled environmental conditions. The central processing system may include various stations and functionality both for preparing crop-bearing modules to be inserted in the controlled growth environment, for harvesting crops from the crop-bearing modules after they have been extracted from the controlled growth environment, and for cleaning or washing crop-bearing modules for re-use. The controlled growth environment may include vertical farming structure having vertical grow towers and associated conveyance mechanisms for moving the vertical grow towers along one or more grow lines.

Abstract: An integrated circuit (IC) memory device includes an array of storage cells configured into multiple banks. Interface circuitry receives refresh commands from a host memory controller to refresh the multiple banks for a first refresh mode. On-die refresh control circuitry selectively generates local refresh commands to refresh the multiple banks in cooperation with the host memory controller during a designated hidden refresh interval in a second refresh mode. Mode register circuitry stores a value indicating whether the on-die refresh control circuitry is enabled for use during the second refresh mode. The interface circuitry includes backchannel control circuitry to transmit a corrective action control signal during operation in the second refresh mode.

Abstract: Systems and methods are provided for dynamically modeling and depicting overall emissions of the aviation industry and changes thereto when taking into account, for example, traffic growth and introduction of sustainability strategies, such as new and/or improved technologies, an increase in operational efficiency, and carbon offsets. Using the dynamic tool described herein, users can define scenarios on how to reduce emissions through the introduction of different sustainability strategies, both statically and over time, analyze the impact of those strategies on emissions, and understand the dependencies between select strategies.

Abstract: A high-capacity cache memory is implemented by multiple heterogenous DRAM dies, including a dedicated tag-storage DRAM die architected for low-latency tag-address retrieval and thus rapid hit/miss determination, and one or more capacity-optimized cache-line DRAM dies that render a net cache-line storage capacity orders of magnitude beyond that of state-of-the art SRAM cache implementations. The tag-storage die serves double-duty in some implementations, yielding rapid tag hit/miss determination for cache-line read/write requests while also serving as a high-capacity snoop-filter in a memory-sharing multiprocessor environment.

Abstract: A system for operating and/or lubricating a plurality of valves. The system includes at least first and second control units, each of which is associated with a respective valve. Each control unit includes a hydraulic pressure inlet, a hydraulic pressure outlet, a hydraulic pressure line connected between the hydraulic pressure inlet and the hydraulic pressure outlet, and a hydraulic port which is connectable to the valve. The hydraulic pressure inlet of the first control unit is connectable to a hydraulic pressure source and the hydraulic pressure outlet of the first control unit is connectable to the hydraulic pressure inlet of the second control unit. In operation, the control unit is operable to selectively communicate hydraulic pressure from the hydraulic pressure line to the hydraulic port.

Abstract: An interconnected stack of one or more Dynamic Random Access Memory (DRAM) die has a base logic die and one or more custom logic or processor die. The processor logic die snoops commands sent to and through the stack. In particular, the processor logic die may snoop mode setting commands (e.g., mode register set—MRS commands). At least one mode setting command that is ignored by the DRAM in the stack is used to communicate a command to the processor logic die. In response the processor logic die may prevent commands, addresses, and data from reaching the DRAM die(s). This enables the processor logic die to send commands/addresses and communicate data with the DRAM die(s). While being able to send commands/addresses and communicate data with the DRAM die(s), the processor logic die may execute software using the DRAM die(s) for program and/or data storage and retrieval.

Abstract: An example method includes capturing, via an x-ray machine, a plurality of x-ray images of a patient covering a number of different anatomy of the patient in any order, using a machine learning algorithm to process the plurality of x-ray images for identification of an anatomy in respective x-ray images of the plurality of x-ray images, associating a label with each of the plurality of x-ray images based on the identification of the anatomy, positioning each of the plurality of x-ray images upright based on a preset coordinate scheme for the anatomy, arranging the plurality of x-ray images into a predetermined order based on the species of the patient, and generating and outputting a data file including the plurality of x-ray images in the predetermined order, positioned upright, and labeled.

Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.

Abstract: An online agricultural system manages and optimizes interactions of entities within the system to enable the execution of transaction and the transportation of crop products. The online agricultural system accesses historic and environmental data describing factors that may impact crop product transactions and/or transportation to determine market prices for crop products and crop product transportation. Responsive to receiving a request from an entity, the online agricultural system determines an optimal transaction for the entity, such as a price for selling a crop product, an available crop product for purchase, or a transportation opportunity to transport a crop product.

Abstract: An intervertebral fusion device comprising inferior and superior fusion cage devices that provide an ability to correct spondylolisthesis via in-situ adjustment.

Abstract: In a method and system for viewer interaction with streaming media, a scene from a media presentation is displayed with a broadcasting device that includes an operating system level broadcaster interface overlay. The overlay generates an image frame from the scene. The image frame is sent to a viewer device. Viewer interaction parameters are received from a viewing device and a viewer interaction is displayed over a subsequent scene from the media presentation with the broadcaster interface overlay. On a viewing device an image frame from the media presentation is received from the broadcasting device. An operating system level viewer interface overlay is generated over the image frame and the image frame of the media presentation is displayed. Viewer interaction parameters are generated from a viewer interaction with the operating system level viewer interface overlay and sent to the broadcasting device.