Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: This disclosure relates generally to an injection device having a plunger configured to advance a distance into a container of material, such as a viscoelastic container; a trigger mechanism configured upon an actuation of the trigger mechanism to apply a first force to a spring element; and the spring element coupled to the plunger and configured to apply a second force to the plunger and which is configured to prevent exceeding a threshold maximum force applied to the container.

Abstract: A hand-held aspiration device is provided which has a relatively small suction volume along a suction path to improve responsiveness of the aspiration device when the device is activated. The device may be manually powered and may be provided without electronic controls. The device has a suction path which may be purged into a disposal enclosure to reduce the volume of material under the influence of the suction pressure during the procedure. The suction source may also be part of the hand-held unit to further reduce the suction path and suction volume.

Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: Disclosed are devices and methods for treatment of eye disease such as glaucoma. Implants are described herein that create a flow field, such as between the anterior chamber and either the supraciliary space or suprachoroidal space. In addition, the implant can be treated with one or more treatments, including plasma treatments, for creating a variety of surface features and characteristics. Some of the surface features and characteristics can assist in controlling tissue responses to the implanted implant, including promoting or preventing tissue proliferation.

Abstract: Disclosed are devices, methods and systems for treatment of eye disease, including open angle glaucoma and narrow angle glaucoma. Implants are described herein that create a directed flow field, such as between the anterior chamber and either the supraciliary space or suprachoroidal space. In addition, the implant can include a variety of features, including extruded features, such as rings and pegs, which can assist in preventing ocular tissue from collapsing onto the implant and occluding fluid pathways.

Abstract: Systems and methods for providing transapical access to a heart chamber for performing an intra cardiac procedure are described. The systems include a helical needle driver and a dilator. The helical needle driver rotates and translates a shuttle member which advances one or more helical needles to place a helical suture within the myocardium. After removing the needles, the dilator is advanced through the pre-placed helical suture, dilating both a passage and the circumscribing suture. After performing procedure, the pre-placed suture may be closed by proximally retracting an external end of the suture.

Abstract: Disclosed herein are devices and methods related to implants for treating one or more physiological conditions of the eye. Some embodiments disclosed herein include an expandable ocular implant for implanting in an eye. The expandable implant can include an implant having an elongate tubular body and an expandable sheath securely adapted to a part of the implant. Some embodiments of the expandable sheath can have at least one expandable feature that can assist the expandable sheath in forming a compact and an expanded configuration.

Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: A device and method for moving a membrane into contact and out of contact with the surface of a skin of a patient. The membrane contains at least one active pharmaceutical ingredient (API) and is configured to release the API to the patient when the membrane is in contact with the skin. The device includes components which control the timing of the movement of the membrane based on intended drug delivery profiles. The device may control the amount of surface area of the membrane contacting the skin or the pressure of the membrane on the skin to additionally adjust the drug delivery profile. The membrane may be on a translating platform which moves to a down position where the membrane is in contact with the skin or to an up position where the membrane is not in contact with the skin.

Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: Suture anchoring devices include retention features that will hold the anchoring devices in place and resist displacement when tension is applied to an attached suture in a direction opposite direction of placement. The anchors may be deployed by a needle shaft in a placement direction (which may be straight, curved, or a combination of both), and the needle shaft may have a sharpened or a blunt tip depending on the nature of the anchor. The anchors will find use when a distal end of the suture attached to the anchor is to be left in place in solid tissue so that it cannot be tied off.

Abstract: Disclosed are devices and methods for treatment of eye disease such as glaucoma. Implants are described herein that create a flow field, such as between the anterior chamber and either the supraciliary space or suprachoroidal space. In addition, the implant can be treated with one or more treatments, including plasma treatments, for creating a variety of surface features and characteristics. Some of the surface features and characteristics can assist in controlling tissue responses to the implanted implant, including promoting or preventing tissue proliferation.

Abstract: This disclosure relates generally to methods and devices for use in treating eye conditions. In some embodiments, a site-specific therapeutic agent is mixed with a releasing agent with a dual syringe apparatus in order to achieve homogeneity. Once mixed, the site-specific therapeutic agent and releasing agent can be either dispensed directly within an area of the eye or within an implant. The implant can be at least partially filled with the site-specific therapeutic agent and releasing agent either prior to or after implantation into the eye. Some ratios of site-specific therapeutic agents to releasing agents are disclosed which provide various releasing profiles of the site-specific therapeutic agent within the eye.

Abstract: This disclosure relates generally to an injection device having a plunger configured to advance a distance into a container of material, such as a viscoelastic container; a trigger mechanism configured upon an actuation of the trigger mechanism to apply a first force to a spring element; and the spring element coupled to the plunger and configured to apply a second force to the plunger and which is configured to prevent exceeding a threshold maximum force applied to the container.

Abstract: This disclosure relates generally to methods and devices for an ocular implant which can be positioned in the Schlemm's canal of a patient's eye for improving fluid flow, such as aqueous fluid, through the eye. The ocular implant can have a variety of shapes and sizes which can allow the ocular implant to be implanted in the Schlemm's canal for applying a force, including a predetermined force, along a part of the Schlemm's canal. The force applied by the ocular implant can change the shape of the Schlemm's canal which can increase the flow volume within and through the Schlemm's canal.

Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: Disclosed are devices, methods and systems for treatment of eye disease, including open angle glaucoma and narrow angle glaucoma. Implants are described herein that create a directed flow field, such as between the anterior chamber and either the supraciliary space or suprachoroidal space. In addition, the implant can include a variety of features, including extruded features, such as rings and pegs, which can assist in preventing ocular tissue from collapsing onto the implant and occluding fluid pathways.

Abstract: Disclosed herein are devices and methods related to implants for treating one or more physiological conditions of the eye. Some embodiments disclosed herein include an expandable ocular implant for implanting in an eye. The expandable implant can include an implant having an elongate tubular body and an expandable sheath securely adapted to a part of the implant. Some embodiments of the expandable sheath can have at least one expandable feature that can assist the expandable sheath in forming a compact and an expanded configuration.