Patents by Inventor Michael Schnall-Levin

Michael Schnall-Levin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and systems for processing polynucleotides
    Patent number: 11473138
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. In some cases, this disclosure provides methods for the generation of polynucleotide barcode libraries, and for the attachment of such polynucleotides to target polynucleotides.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: October 18, 2022
    Assignee: 10X GENOMICS, INC.
    Inventors: Benjamin Hindson, Mirna Jarosz, Paul Hardenbol, Michael Schnall-Levin, Kevin Ness, Serge Saxonov
  • Methods and compositions for nucleic acid analysis
    Patent number: 11473125
    Abstract: The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: October 18, 2022
    Assignee: 10X GENOMICS, INC.
    Inventors: Xinying Zheng, Serge Saxonov, Michael Schnall-Levin, Kevin Ness, Rajiv Bharadwaj
  • Methods and systems for processing polynucleotides
    Patent number: 11441179
    Abstract: This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provides herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: September 13, 2022
    Assignee: 10X GENOMICS, INC.
    Inventors: Christopher Hindson, Michael Schnall-Levin, Andrew Price, Paul Hardenbol, Yuan Li
  • Methods and systems for processing polynucleotides
    Patent number: 11421274
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: August 23, 2022
    Assignee: 10X GENOMICS, INC.
    Inventors: Benjamin Hindson, Serge Saxonov, Kevin Ness, Paul Hardenbol, Michael Schnall-Levin, Mirna Jarosz
  • Spatial analysis of DNA methylation
    Patent number: 11408029
    Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: August 9, 2022
    Assignee: 10x Genomics, Inc.
    Inventors: Layla Katiraee, Michael Schnall-Levin, Christina Galonska, Marlon Stoeckius
  • MOLECULAR ARRAYS AND METHODS FOR GENERATING AND USING THE ARRAYS
    Publication number: 20220228201
    Abstract: Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate. Compositions such as nucleic acid arrays produced by the methods are also disclosed. In some embodiments, provided herein is photocontrollable hybridization, where oligonucleotides with photo-caged bases prevent hybridization of complementary nucleic acid strands. Uncaging of the oligonucleotides allows hybridization and/or ligation of nucleic acid molecules at the exposed area. A large diversity of barcodes can be created in molecules on the substrate via sequential rounds of light exposure, hybridization, and ligation.
    Type: Application
    Filed: December 29, 2021
    Publication date: July 21, 2022
    Inventors: Geoffrey MCDERMOTT, David Michael PATTERSON, Andrew D. PRICE, Eswar Prasad RAMACHANDRAN IYER, Michael SCHNALL-LEVIN
  • Systems and methods for nucleic acid processing using degenerate nucleotides
    Patent number: 11371094
    Abstract: Provided herein are compositions, systems and methods for tagging molecular events, reactions, species, etc., but without the need for complex, highly diverse libraries of tagging molecules. Provided are tagging moieties that can have a smaller number, a few, or even a single original “tagging” structure that may be transformed or transformable, in situ, into a collection of larger numbers of unique tagging or “barcode” moieties.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: June 28, 2022
    Assignee: 10X Genomics, Inc.
    Inventors: Paul Ryvkin, Jason Underwood, Michael Schnall-Levin, Tarjei Mikkelsen, Benjamin Hindson
  • METHODS AND SYSTEMS FOR DROPLET-BASED SINGLE CELL BARCODING
    Publication number: 20220195420
    Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
    Type: Application
    Filed: November 2, 2021
    Publication date: June 23, 2022
    Inventors: Zahra Kamila Belhocine, Rajiv Bharadwaj, Christopher Hindson, Michael Schnall-Levin, Bill Kengli Lin, Anthony Makarewicz, Pranav Patel, Katherine Pfeiffer, Andrew D. Price, Mohammad Rahimi Lenji, Tobias Daniel Wheeler, Yifeng Yin
  • Systems and methods for nucleic acid preparation and analysis
    Patent number: 11365438
    Abstract: The present disclosure provides methods and systems for nucleic acid preparation and analysis. Nucleic acid molecules may be derived from one or more cells. Preparation of nucleic acid molecules may comprise generation of one or more mutations, such as strand-specific mutations. Nucleic acid molecules may be prepared for and analyzed by sequencing. Sequences may be identified with nucleic acid orientation information.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: June 21, 2022
    Assignee: 10X GENOMICS, INC.
    Inventors: Daniel P. Riordan, Preyas Shah, Michael Schnall-Levin
  • PARTITIONING AND PROCESSING OF ANALYTES AND OTHER SPECIES
    Publication number: 20220154175
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: November 2, 2021
    Publication date: May 19, 2022
    Inventors: Benjamin Hindson, Serge Saxonov, Kevin Ness, Paul Hardenbol, Christopher Hindson, Donald Masquelier, Mirna Jarosz, Michael Schnall-Levin
  • SPATIAL ANALYSIS OF DNA METHYLATION
    Publication number: 20220127666
    Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.
    Type: Application
    Filed: January 11, 2022
    Publication date: April 28, 2022
    Inventors: Layla Katiraee, Michael Schnall-Levin, Christina Galonska, Marlon Stoeckius
  • SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCE ASSEMBLY
    Publication number: 20220115090
    Abstract: Methods, processes, and particularly computer implemented processes and computer program products are provided for use in the analysis of genetic sequence data. The processes and products are employed in the assembly of shorter nucleic acid sequence data into longer linked and preferably contiguous genetic constructs, including large contigs, chromosomes and whole genomes.
    Type: Application
    Filed: August 25, 2021
    Publication date: April 14, 2022
    Inventors: Michael Schnall-Levin, Iain MacCallum
  • METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES
    Publication number: 20220098659
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Application
    Filed: August 3, 2021
    Publication date: March 31, 2022
    Inventors: Benjamin Hindson, Christopher Hindson, Michael Schnall-Levin, Kevin Ness, Mirna Jarosz, Serge Saxonov, Paul Hardenbol
  • CAPSULE ARRAY DEVICES AND METHODS OF USE
    Publication number: 20220081704
    Abstract: This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation operations may be used as a prelude to one more or more analysis operations. For example, a device of this disclosure can achieve physical partitioning and discrete mixing of samples with unique molecular identifiers within a single unit in preparation for various analysis operations. The device may be useful in a variety of applications and most notably nucleic-acid-based sequencing, detection and quantification of gene expression and single-cell analysis.
    Type: Application
    Filed: June 21, 2021
    Publication date: March 17, 2022
    Inventors: Benjamin Hindson, Serge Saxonov, Michael Schnall-Levin
  • Methods and compositions for targeted nucleic acid sequence coverage
    Patent number: 11274343
    Abstract: The present invention is directed to methods, compositions and systems for analyzing sequence information from targeted regions of a genome. Such targeted regions may include regions of the genome that are poorly characterized, highly polymorphic, or divergent from reference genome sequences.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: March 15, 2022
    Assignee: 10X GENOMICS, INC.
    Inventors: Mirna Jarosz, Michael Schnall-Levin
  • Methods and systems for analysis of cell lineage
    Patent number: 11255847
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from a single cell. Such polynucleotide processing may be useful for a variety of applications, including cell lineage analysis. Cell lineage analysis may comprise the use of one or more lineage tracing nucleic acid molecules. The disclosed methods may comprise using a lineage tracing nucleic acid molecule to identify a biological particle with one or more progenitor cells.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: February 22, 2022
    Assignee: 10X Genomics, Inc.
    Inventor: Michael Schnall-Levin
  • GENERATING CAPTURE PROBES FOR SPATIAL ANALYSIS
    Publication number: 20220033888
    Abstract: The present disclosure relates to compositions and methods for generating capture probes on a substrate for identifying the location of analytes in a biological sample.
    Type: Application
    Filed: December 6, 2019
    Publication date: February 3, 2022
    Applicant: 10x Genomics, Inc.
    Inventors: Michael Schnall-Levin, Eswar Prasad Ramachandran Iyer, Yifeng Yin, Tarjei Sigurd Mikkelsen, Preyas Shah, Geoffrey McDermott, Adam Lowe, Joshua Delaney, Augusto Manuel Tentori, Rajiv Bharadwaj, Stefania Giacomello, Alexander Gagnon, Meghan L. F. Frey, Zachary Bent, Erik Leonard Henrik Borgstrom
  • Partitioning and processing of analytes and other species
    Patent number: 11193121
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: December 7, 2021
    Assignee: 10X GENOMICS, INC.
    Inventors: Benjamin Hindson, Serge Saxonov, Kevin Ness, Paul Hardenbol, Christopher Hindson, Donald Masquelier, Mirna Jarosz, Michael Schnall-Levin
  • Methods and systems for droplet-based single cell barcoding
    Patent number: 11193122
    Abstract: Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: December 7, 2021
    Assignee: 10X GENOMICS, INC.
    Inventors: Zahra Kamila Belhocine, Rajiv Bharadwaj, Christopher Hindson, Michael Schnall-Levin, Bill Kengli Lin, Anthony Makarewicz, Pranav Patel, Andrew D. Price, Mohammad Rahimi Lenji, Tobias Daniel Wheeler, Yifeng Yin
  • METHODS AND SYSTEMS FOR ANTIGEN SCREENING
    Publication number: 20210372998
    Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.
    Type: Application
    Filed: March 22, 2021
    Publication date: December 2, 2021
    Inventors: Zahra Kamila Belhocine, Jason Bell, Zachary Bent, Rajiv Bharadwaj, Christopher Hindson, Mohammad Rahimi Lenji, Bill Kengli Lin, Anthony Makarewicz, Geoffrey McDermott, Elliott Meer, Francesca Meschi, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Michael Schnall-Levin, Sarah Taylor, Jessica Michele Terry, Tobias Daniel Wheeler, Yifeng Yin, Xinying Zheng, Solongo Batjargal Ziraldo, Eswar Prasad Ramachandran Iyer, Luigi Jhon Alvarado Martinez