Patents by Inventor Michael Seul

Michael Seul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150126407
    Abstract: This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
    Type: Application
    Filed: September 15, 2014
    Publication date: May 7, 2015
    Inventors: Michael Seul, Chiu Wo Chau, Hui Huang, Sukanta Banerjee, Jiacheng Yang, Ye Hong
  • Publication number: 20150126389
    Abstract: In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps: adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
    Type: Application
    Filed: August 1, 2014
    Publication date: May 7, 2015
    Inventors: Michael SEUL, Yi ZHANG, Sukanta BANERJEE, Jiacheng YANG, Chiu CHAU
  • Patent number: 8999731
    Abstract: The present application provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: April 7, 2015
    Assignee: BioArray Solutions, Ltd.
    Inventors: Michael Seul, Chiu Wo Chau
  • Publication number: 20150032632
    Abstract: Genetic information relating to clinically significant attributes are generated as unique molecular signatures, which are provided to a subscriber to be carried as a card or in another form, including for display by a subscriber's computer or smart-phone or PDA. The signature is periodically updated as new clinically significant attributes become known. The process of updating the signature and using it to obtain suitable products (which don't have an unacceptable risk of generating an adverse reaction or outcome) is also described.
    Type: Application
    Filed: June 19, 2014
    Publication date: January 29, 2015
    Inventor: Michael Seul
  • Publication number: 20150024974
    Abstract: The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interations of a number of analyte molecules in a sample.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 22, 2015
    Applicant: BioArray Solutions, Ltd.
    Inventors: Sukanta BANERJEE, Michael Seul, Alice X. Li
  • Patent number: 8932989
    Abstract: A method of selecting nucleic acid samples from a plurality of nucleic acid samples based on desired alleles including the steps of performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the desired alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to select nucleic acid sample. In some embodiments, the first reaction may not be performed. A source tag sharing number “d” may be determined for each of the alleles. Alleles may be binned together.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: January 13, 2015
    Assignee: Bioinventors & Entrepreneurs Network, LLC
    Inventor: Michael Seul
  • Publication number: 20140369579
    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
    Type: Application
    Filed: March 10, 2014
    Publication date: December 18, 2014
    Applicant: Bioarray Solutions, Ltd.
    Inventors: Michael Seul, Xiongwu Xia, Chiu Chau, Scott Determan
  • Publication number: 20140358446
    Abstract: Disclosed are methods for establishing the compatibility between two blood types on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of blood types constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.
    Type: Application
    Filed: April 18, 2014
    Publication date: December 4, 2014
    Applicant: BIOARRAY SOLUTIONS, LTD.
    Inventors: Yi Zhang, Michael Seul
  • Publication number: 20140262782
    Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations.
    Type: Application
    Filed: February 14, 2014
    Publication date: September 18, 2014
    Applicant: Bioarray Solutions, Ltd
    Inventor: Michael Seul
  • Publication number: 20140257858
    Abstract: Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be Integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 11, 2014
    Applicant: BIOARRAY SOLUTIONS, LTD.
    Inventors: Michael Seul, Robert Danehy
  • Patent number: 8795960
    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3? terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: August 5, 2014
    Assignee: Bioarray Solutions, Ltd.
    Inventors: Michael Seul, Sukanta Banerjee, Jiacheng Yang, Tatiana Vener
  • Patent number: 8795966
    Abstract: In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps: adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: August 5, 2014
    Assignee: BioArray Solutions, Ltd.
    Inventors: Michael Seul, Yi Zhang, Sukanta Banerjee, Jiacheng Yang, Chiu Chau
  • Patent number: 8712123
    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: April 29, 2014
    Assignee: Bioarray Solutions, Ltd.
    Inventors: Xiongwu Xia, Michael Seul, Chiu Chau, Scott Determan
  • Patent number: 8691594
    Abstract: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: April 8, 2014
    Assignee: Bioarray Solutions, Ltd.
    Inventor: Michael Seul
  • Patent number: 8615367
    Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: December 24, 2013
    Assignee: Bioarray Solutions, Ltd.
    Inventors: Michael Seul, Chiu Wo Chau, Enqing Tan
  • Publication number: 20130317845
    Abstract: Apparatuses, methods, and computer readable medium, for fulfilling a need for at least one perishable item, the method including reserving a plurality of perishable items with at least partially unknown attribute profiles from a supplier; receiving values for at least some of the reserved at least partially unknown attribute profiles, wherein the received values are determined by tests conducted after the reserving step; determining based on the received values which of the plurality of perishable items satisfy the need for the at least one perishable item; and if at least one of the plurality of perishable items does not satisfy the need for the at least one perishable item, unreserving the at least one perishable item of the plurality of perishable items determined not to satisfy the need for the at least one perishable item.
    Type: Application
    Filed: August 5, 2013
    Publication date: November 28, 2013
    Applicant: Bioinventors & Entrepeneurs Network, LLC
    Inventors: Michael Seul, Andreas E. Gocksch
  • Publication number: 20130288920
    Abstract: The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interations of a number of analyte molecules in a sample.
    Type: Application
    Filed: June 26, 2013
    Publication date: October 31, 2013
    Inventors: Sukanta Banerjee, Michael Seul, Alice X. Li
  • Patent number: 8504388
    Abstract: Apparatuses, methods, and computer readable medium, for fulfilling a need for at least one perishable item, the method including reserving a plurality of perishable items with at least partially unknown attribute profiles from a supplier; receiving values for at least some of the reserved at least partially unknown attribute profiles, wherein the received values are determined by tests conducted after the reserving step; determining based on the received values which of the plurality of perishable items satisfy the need for the at least one perishable item; and if at least one of the plurality of perishable items does not satisfy the need for the at least one perishable item, unreserving the at least one perishable item of the plurality of perishable items determined not to satisfy the need for the at least one perishable item.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: August 6, 2013
    Assignee: Bioinventors & Entrepeneurs Network, LLC
    Inventors: Michael Seul, Andreas E. Gocksch
  • Patent number: 8486720
    Abstract: The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: July 16, 2013
    Assignee: BioArray Solutions, Ltd.
    Inventors: Sukanta Banerjee, Michael Seul, Alice X. Li
  • Patent number: 8486629
    Abstract: Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5?-end, (or possibly at the 3? end) to an encoded carrier such as a color-coded microparticle (“bead”). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: July 16, 2013
    Assignee: BioArray Solutions, Ltd.
    Inventors: Sukanta Banerjee, Jiacheng Yang, Michael Seul