Abstract: The present disclosure provides particles with a polymeric core containing a pharmaceutically active agent; and an antibody fragment conjugated to the surface of the particle, wherein the antibody fragment targets an endogenous immune cell subset (e.g., an endogenous T-cell or a myeloid-derived suppressor cell). The present invention provides methods for forming and methods for using the particles. The particles described herein may be useful in treating and/or preventing proliferative disease, inflammatory disease, or neoplastic disorders (e.g., cancer, autoimmune diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a particle described herein.

Abstract: A turbine engine assembly is provided. The assembly includes a low-pressure turbine assembly including a first turbine section configured to rotate in a first rotational direction at a first rotational speed, and a second turbine section configured to rotate in a second rotational direction at a second rotational speed. The second rotational direction is opposite the first rotational direction and the second rotational speed is lower than the first rotational speed. The assembly also includes a first drive shaft coupled to the first turbine section, and a fan assembly including a first fan section coupled to the first drive shaft such that the first fan section rotates in the first rotational direction at the first rotational speed, and a second fan section coupled to the second turbine section such that the second fan section rotates in the second rotational direction at the second rotational speed.

Abstract: A propulsion system for an aircraft includes a turbomachine, a primary fan, and an electric machine. The turbomachine includes a first turbine and a second turbine, with at least one of the first turbine or second turbine operably connected to the electric machine and the second turbine driving the primary fan. The propulsion system additionally includes an auxiliary propulsor assembly configured to be mounted at a location away from the turbomachine and the primary fan. The electric machine is in electrical communication with the auxiliary propulsor assembly for transferring power with the auxiliary propulsor assembly during operation of the propulsion system.

Abstract: An aircraft propulsor assembly includes a fan having a nacelle and plural fan blades radially disposed within the nacelle. The fan blades are configured to be rotated by torque generated by a turbine engine of an aircraft to generate thrust for propelling the aircraft. The assembly also includes an electric motor including a stator in the nacelle of the fan and a rotor in tips of two or more of the fan blades. The electric motor is configured to generate torque that also rotates the fan blades to generate thrust for propelling the aircraft. The assembly also includes a controller configured to reduce or prevent an increase in an operating temperature of the turbine engine of the aircraft by automatically supplanting at least some of the torque generated by the turbine engine with the torque generated by the electric motor.

Abstract: An initial image associated with a stored profile of the user is presented on a display device. Input including a manipulation of the initial image to transform the initial image to a manipulated initial image is received on an input device. The user is authenticated in response to the manipulated initial image sufficiently matching a target manipulated image associated with the stored profile of the user. Optionally, prior to presenting the initial image, a facial image of the user is captured. The user is identified by applying a facial recognition technique to the captured facial image of the user. The display device is arranged to present the initial image in response to identifying the user as having a stored profile.

Abstract: There is provided a method (100) for aligning and positioning an implant (305). The method (100) comprises creating a reference using a guide (500) configured in accordance with patient specific data; fixing the reference using a reference marker (920) and delivering the implant (305) with an impactor (1005) aligned in accordance with the reference. Guide light emission means (515a) may be employed to create the reference, reference marker light emission means (515b) may be employed to fix the reference and impactor light emission means (515c) may be employed to align an impactor (1005).

Abstract: A shrouded fan assembly for use with a gas turbine engine includes a central hub and a plurality of variable-pitch fan blades coupled to and extending radially outward from the central hub. Each variable-pitch fan blade includes a radially outer tip is rotatable about a longitudinal axis extending therethrough. A shroud is coupled to each radially outer tip.

Abstract: A processing unit includes a circuit including a current mirror, and a capacitor providing a weight based on a charge level of the capacitor. The capacitor is charged or discharged by the current mirror.

Abstract: A resistive processing unit (RPU) includes a circuit including at least two current mirrors connected in series, and a capacitor connected with the at least two current mirrors, the capacitor providing a weight based on a charge level of the capacitor. The capacitor is charged or discharged by one of the at least two current mirrors.

Abstract: In one aspect, a particle comprising a core containing at least one pharmaceutically active agent and a coating covering the surface of the particle that comprises a biocompatible adhesive polymer is provided. The core may comprise two or more components, such as two pharmaceutically active agents or a pharmaceutically active agent and a major constituent of the core, having at least one dissimilar chemical or physical property (e.g., molecular weight, solubility, c Log P). In some such embodiments, placement of the uncoated core in certain environments results in the rapid release of a component (e.g., a pharmaceutically active agent) from and/or destabilization and breakdown of the core. In some embodiments, the biocompatible adhesive polymer in the coating acts as a molecular glue to stabilize the core and/or alter the release kinetics of at least one pharmaceutically active agent.

Abstract: A tuned cavity rotating detonation combustion system includes a an annular chamber having an inlet and an outlet; a valve plate at the inlet of the annular chamber and comprising a plurality of openings spaced circumferentially around the inlet; a plurality of tubes each having an open end in communication with a corresponding opening of the valve plate and a closed end forming a tuned cavity, and a first opening between the open end and the closed end for injection of air; and a plurality of fuel injectors corresponding to the plurality of tubes, each fuel injector being configured to inject fuel into the tube between the first opening and the open end. Each of the tuned cavities has a length sized to resonate at a same frequency as a continuous detonation frequency of at least one detonation wave in the annular chamber.

Abstract: A virtual aerodynamic component for a wind turbine including at least one rotor blade connected to a hub. The at least one rotor blade defines an inner portion and a profiled outer portion. The virtual aerodynamic component includes one or more air-blowing units configured to provide a flow of air substantially opposed to an incoming wind. The flow of air defines the virtual aerodynamic component in front of the inner portion of the at least one rotor blade and provides for redirection of the incoming wind toward the profiled outer portion of the at least one rotor blade in an operational state and allows the incoming wind to flow toward the inner portion of the at least one rotor blade in a non-operational state. Further described is a wind turbine including the above-described virtual aerodynamic component and method for aerodynamic performance enhancement of an existing wind turbine.

Abstract: In one aspect, a method for forming particles is provided. The method may allow biocompatible particles comprising an agent (e.g., pharmaceutically active agent) to be produced absent one or more purification step (e.g., removal of excess reagent). In certain embodiments, particles, produced as described herein, can be utilized in a pharmaceutical composition and/or administered to a subject without further purification. The lack of one or more purification step may simplify manufacturing and/or minimize or eliminate the loss of agent from the particle after formation. In some embodiments, the method comprises associating albumin with an agent and crosslinking to form particles, such that little or no cytotoxic molecules are produced and/or remain after particle formation. Cross-linked albumin particles formed via the methods described herein may serve as biocompatible carriers for a variety of agents.

Abstract: A shrouded fan assembly for use with a gas turbine engine includes a central hub and a plurality of variable-pitch fan blades coupled to and extending radially outward from the central hub. Each variable-pitch fan blade includes a radially outer tip is rotatable about a longitudinal axis extending therethrough. A shroud is coupled to each radially outer tip.

Abstract: Various systems and methods for authenticating users via image manipulation are described herein. In various embodiments, an initial image associated with a stored profile of the user is presented on a display device. Input including a manipulation of the initial image to transform the initial image to a manipulated initial image is received on an input device. The user is authenticated in response to the manipulated initial image sufficiently matching a target manipulated image associated with the stored profile of the user. In various embodiments, prior to presenting the initial image, a facial image of the user is captured. The user is identified by applying a facial recognition technique to the captured facial image of the user. The display device is arranged to present the initial image in response to identifying the user as having a stored profile.

Abstract: The present disclosure relates to a method incorporating computer-implemented steps, a computing device, and a computer readable storage medium, for developing manufacturing parameters for manufacturing an orthopaedic implant. The method comprises the computer-implemented steps of being responsive to patient specific information data for deriving patient data, where the patient specific information data is indicative of one or more dynamic characteristics, being responsive to the patient data for calculating design data for the orthopaedic implant, and developing the manufacturing parameters for manufacturing the orthopaedic implant according to the design data.

Abstract: The present disclosure relates to a method incorporating computer-implemented steps, a computing device, a computer readable storage medium, and a client computing device for modelling the alignment of an orthopedic implant for a joint of a patient. The method comprises the computer-implemented steps of being responsive to patient specific information data for deriving patient data, where the patient specific information data is indicative of one or more dynamic characteristics, and being responsive to the patient data for providing 3D model data of the joint, such that the 3D model data shows the orthopedic implant in an alignment configuration based on the patient specific information data.

Abstract: Various systems and methods for authenticating users via image manipulation are described herein. An initial image associated with a stored profile of a user may be presented on a display device. Input including a manipulation of the initial image to transform the initial image to a manipulated initial image is received on an input device. The user is authenticated in response to the manipulated initial image sufficiently matching a target manipulated image associated with the stored profile of the user. Prior to presenting the initial image, a facial image of the user may be captured. The user is identified by applying a facial recognition technique to the captured facial image of the user. The display device is arranged to present the initial image in response to identifying the user as having a stored profile.

Abstract: The described embodiments provide thermal energy via solar powered heat exchangers. This energy can be implemented to heat hot water or heat residential/commercial structures. Parallel mounted vacuum insulated tubes heat water within a geometric heat transfer piping system. This thermal energy is transferred via a piping system to an insulated tank. A digital controller monitors and controls the temperature of the water within the system as well as provides frost/freezing protection. An electrical active pumping system is connected to the digital controller to circulate water within the solar heat exchanger. The electric active pump can be connected to a solar photovoltaic (electric) panel for reliable and uninterrupted heat/hot water delivery.

Abstract: A turbine engine assembly is provided. The assembly includes a low-pressure turbine assembly including a first turbine section configured to rotate in a first rotational direction at a first rotational speed, and a second turbine section configured to rotate in a second rotational direction at a second rotational speed. The second rotational direction is opposite the first rotational direction and the second rotational speed is lower than the first rotational speed. The assembly also includes a first drive shaft coupled to the first turbine section, and a fan assembly including a first fan section coupled to the first drive shaft such that the first fan section rotates in the first rotational direction at the first rotational speed, and a second fan section coupled to the second turbine section such that the second fan section rotates in the second rotational direction at the second rotational speed.