Abstract: Provided herein are compounds of formula (I) and (II), or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof.

Abstract: A Data Over Cable Interface Specification (DOCSIS) node includes a first DOCSIS port and a second DOCSIS port. The node also includes a plurality of radio frequency (RF) ports. A plurality of client devices can be coupled to the RF ports. A RF switching network is coupled between the first DOCSIS port and the second DOCSIS port, and the plurality of RF ports. One or more control circuits can switch the RF switching network between at least a first state and a second state. The switching of the RF switching network allows the one or more control circuits to identify which client devices are coupled to which RF ports of the node.

Abstract: A computer-assisted device includes a first repositionable arm configured to support a first end effector, a second repositionable arm configured to support a second end effector, and a control unit. The control unit configured to monitor an actual motion of at least one structure selected from the group consisting of the first repositionable arm and the first end effector; determine a deviation between the actual motion and a desired motion of the at least one structure; and in response to determining that the deviation is greater than a deviation threshold, select whether to halt motion of the first repositionable arm and the first end effector or the second repositionable arm and the second end effector based on a mode of operation of the first repositionable arm the first end effector, the second repositionable arm, or a mode of operation of the second end effector.

Abstract: A stand mixer is provided having a motor, an attachment support coupled to the motor, a mixing shaft coupled to the motor, a retractable plunger, and a mixing attachment. The mixing shaft may be rotatable by the motor. The retractable plunger may be extendable between a first position into the mixing shaft and a second position extending from the mixing shaft. The mixing attachment may be removably attached to the mixing shaft and may define a shaft channel for sliding receipt of the mixing shaft. The mixing attachment may also define an aperture connected with the with the shaft channel and configured for selective receipt of the retractable plunger. The mixing shaft can be inserted into the shaft channel and may be moved to selectively lock the mixing attachment to the mixing shaft by receipt of the retractable plunger into the aperture of the mixing attachment.

Abstract: A computer-assisted device includes a first repositionable arm configured to support a first end effector, a second repositionable arm configured to support a second end effector, and a control unit. The control unit configured to monitor an actual motion of at least one structure selected from the group consisting of the first repositionable arm and the first end effector, determine a deviation threshold based on at least one parameter selected from the group consisting of a mode of operation of the first end effector and a mode of operation of the computer-assisted device, and in response to determining that the actual motion of the at least one structure deviates from a desired motion of the at least one structure by more than the deviation threshold, halt motion of the first repositionable arm and the first end effector or halt motion of the second repositionable arm and the second end effector.

Abstract: A system and method of breakaway clutching in a device includes an arm having a first joint and a control unit coupled to the arm. The control unit includes one or more processors. The control unit switches the first joint from a first state of the first joint to a second state of the first joint in response to an external stimulus applied to the arm exceeding a first threshold. Movement of the first joint is more restricted in the first state than in the second state. The control unit further switches the first joint from the second state to the first state in response to a speed associated with the first joint falling below a speed threshold. The first threshold is based on at least one first property of the arm. The speed threshold is based on at least one second property of the arm.

Abstract: A dead-beat escapement break away assembly which consists of, a pallet engagement collet with at least one magnet attached thereto and a pallet alignment feature attached thereto; a pendulum crutch attachment mechanically coupled to the pallet engagement collet; a pallet which is adapted to be magnetically coupled to the pallet engagement collet so as to mechanically engage the pendulum crutch attachment to the pallet, thereby enabling the pallet to break away from the pallet engagement collet when sufficient force is applied to the pallet to overcome the magnetic force of the magnet.

Abstract: A stand mixer is provided having a pivotable head and a sliding stand for receipt of a bowl or other container. The head and bowl stand are pivotally linked such that as the head pivots an axis, the bowl stand moves simultaneously along a vertical direction. A plurality of linkages may be connected between the head and bowl stand to provide for such simultaneous movement.

Abstract: A system includes a manually manipulatable component configured to generate signals when movements of the component are detected and a control module. The control module is configured to determine that there is uncontrolled movement of the component by determining that a distance of a movement of the component relative to a previous position of the component is greater than a threshold distance or determining that a first mechanical degree of freedom (DOF) of the component has moved and a second mechanical DOF of the component has not moved, and command the system to switch from an operating mode to a safe mode in response to determining that there is uncontrolled movement of the component. The previous position is associated with when a last definitive movement of the component was detected. The first mechanical DOF is affected by gravity and the second mechanical DOF is not affected by gravity.

Abstract: A system and method of breakaway clutching in a device includes an arm including a first joint and a control unit coupled to the arm. The control unit includes one or more processors. The control unit switches the first joint from a first state of the first joint to a second state of the first joint in response to an external stimulus applied to the arm exceeding a first threshold, wherein movement of the first joint is more restricted in the first state of the first joint than in the second state of the first joint, switches the first joint from the second state to the first state in response to a speed associated with the first joint falling below a speed threshold, and prevents the switching of the first joint from the first state to the second state when the arm is in a predetermined mode.

Abstract: A system includes a manually movable input control configured to generate signals when a movement of one or more mechanical degrees of freedom of the input control is detected and a control module. The control module is configured to determine whether a movement of the input control is anticipated to cause an instrument to move outside of a safe range of movement of the instrument and command the system to switch from an operating mode to a safe mode in response to determining that the movement of the input control is anticipated to cause the instrument to move outside of the safe range of movement of the instrument. The instrument is separate from the input control. In the operating mode the instrument moves in response to movement of the input control. In the safe mode the instrument does not move in response to movement of the input control.

Abstract: A system, method, and apparatus for observing member behavior and managing a care gap associated with the member are proided that include: determining a current gap-in-care for the member by: receiving an electronic record associated with the member that describes a current health-related behavior of the member; receiving guideline behavior for the member supported by a professional clinical recommendation; and determining a difference between the current health-related behavior of the member and the guideline behavior for the member. Some examples of the system, method, and apparatus may include determining, for a current gap-in-care for the member, actions that, if followed, are capable of at least partially closing the current gap-in-care within a clinically-defined period of time for the member; determining an impact associated with at least partially closing the current gap-in-care for the member according to the actions; and providing a communication to the member that describes the actions.

Abstract: A system, method, and apparatus for managing care gaps associated with a member are provided. The method may include determining a plurality of current gaps-in-care for the member, where each of the plurality of current gaps-in-care for the member is defined as a difference between a current health-related behavior of the member and a guideline behavior for the member; determining for each of the plurality of current gaps-in-care for the member a potential expected value to be captured by reducing the difference; selecting a current gap-in-care from among the plurality of gaps-in-care as a gap-to-address, where the current gap-in-care is selected based on having a higher potential value as compared to at least one other gap-in-care among the plurality of gaps-in-care; and communicating one or more actions for the member to take in connection with at least partially closing the gap-in-care.

Abstract: Conjugates comprising a drug, cell or biological molecule bound to a photoluminescent polymer nanoparticle, in particular a cross-linked polyfluorene nanoparticle, are described herein, as well as their methods of manufacture and their uses in biological imaging and sensing applications.

Abstract: A method of operating a communications network is disclosed. In order to manage a network, it is first necessary to establish the state the network is in. This is difficult in practice because the network operational data stored and transmitted in the network takes a myriad of forms owing to the variety of suppliers and types of network equipment. There is a need to distil that network operational data down to aggregate network operational data which can be taken to provide an indication of the state of the network which is of a manageable size, and to which network management apparatus can react by sending control commands to the network. The problem of generating aggregate network operational data is tackled by identifying the type of each attribute found in each network operational data item, and classifying the network operational data items in a manner which takes account of the identified types and thus provides network aggregate data which more accurately reflects the operational state of the network.

Abstract: A computer-assisted device includes a first repositionable arm configured to support a first end effector, a second repositionable arm configured to support a second end effector, and a control unit. The control unit configured to monitor an actual motion of at least one structure selected from the group consisting of the first repositionable arm and the first end effector, determine a deviation threshold based on at least one parameter selected from the group consisting of a mode of operation of the first end effector and a mode of operation of the computer-assisted device, and in response to determining that the actual motion of the at least one structure deviates from a desired motion of the at least one structure by more than the deviation threshold, halt motion of the first repositionable arm and the first end effector or halt motion of the second repositionable arm and the second end effector.

Abstract: A system and method for rapid halt and recovery of motion deviations in a medical device includes a computer-assisted medical device having a first repositionable arm having one or more first repositionable elements, a second repositionable arm having one or more second repositionable elements, and a control unit communicably coupled to the first and second repositionable arms. The control unit is configured to control motion of the first repositionable arm and the first end effector based on a desired motion, monitor an actual motion of the first repositionable arm and the first end effector, determine whether the actual motion deviates from the desired motion by more than a predetermined threshold, and halt motion of the first repositionable arm and the first end effector, or of the second repositionable arm and the second end effector, when the actual motion deviates from the desired motion by more than the predetermined threshold.

Abstract: A method of operating a communications network is disclosed. Modern communications networks produce vast amounts of network operational data which have the potential to provide a useful summary of the operational state of the network. Whilst processes such as clustering are known for arranging the vast amount of data into groups, the clusters themselves do not provide data which might be easily interpreted by network elements or administrators. Network operational data often comprises a plurality of data items, each of which gives a value for each of a set of attributes. By processing a cluster to identify attributes in the cluster whose values vary less in the cluster then they vary outside of the cluster, and then generating a cluster description which is based on a measure of the central tendency of the values of those attribute in the cluster, an easily interpretable general description of the data items in the cluster is provided.