Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: A method and system provide the ability to build a game world. A story is obtained that provides a textual narrative of a sequence of events. Plot facilities and a set of constraints are extracted from the story. Each of the plot facilities is a conceptual location where an event happens in the story. Each constraint defines a spatial relation between plot facilities. A map is generated based on the set of constraints by: generating a terrain of two dimensional (2D) polygons that is each associated with a biome type, and assigning each plot facility to a point on the terrain. The assigning complies with a maximum number of constraints and utilizes reinforcement learning (RL) to optimize positions of the points.

Abstract: The disclosed technology includes a tank system including a gravity tank configured to contain water at atmospheric pressure, a rigid pressurized tank positioned within the gravity tank and configured to contain water at a pressure greater than atmospheric pressure, and a piston assembly positioned below the rigid pressurized tank and configured to open and close the rigid pressurized tank. The gravity tank is configured to channel water at atmospheric pressure into a toilet bowl at a first velocity and the rigid pressurized tank is configured to channel water at the pressure greater than atmospheric pressure into the toilet bowl at a second velocity. The second velocity is greater than the first velocity.

Abstract: Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Abstract: Nonwoven fabrics are provided that include a first nonwoven layer comprising a first plurality of fine fibers. The first plurality of fine fibers comprises a first polymeric material including (i) a first polymer component and (ii) optionally one or more first additives, wherein the first polymer component comprises a first recycled-polypropylene (rPP) comprising a visbroken spunbond grade polypropylene having a first melt flow rate (MFR) before visbreaking and second MFR after visbreaking, and wherein the second MFR is larger than the first MFR.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: The disclosed technology includes a tank system including a gravity tank configured to contain water at atmospheric pressure, a rigid pressurized tank positioned within the gravity tank and configured to contain water at a pressure greater than atmospheric pressure, and a piston assembly positioned below the rigid pressurized tank and configured to open and close the rigid pressurized tank. The gravity tank is configured to channel water at atmospheric pressure into a toilet bowl at a first velocity and the rigid pressurized tank is configured to channel water at the pressure greater than atmospheric pressure into the toilet bowl at a second velocity. The second velocity is greater than the first velocity.

Abstract: An object detection system includes a first camera having a first field of view and a second camera having a second field of view that overlaps with the first field of view. The object detection system includes object detection logic configured to receive a first image from the first camera and a second image from the second camera and identify an object in both the first and second image. The object detection system further includes object mapping logic configured to identify a location of the object based on the first and second image. The object detection system also includes display logic configured to display the location of the object.

Abstract: A flow tube is axially moveable within an actuator body between a first axial position and a second axial position for actuating a downhole tool, such as for closing a subsurface safety valve. The flow tube includes an interior flow bore for conveying fluids from the tubing string through the actuator body. An external flow tube profile defined on the flow tube includes an upper shoulder for engagement with a wiper in the first axial position, a lower shoulder for engagement with the wiper in the second axial position, and a clearance path between the upper and lower shoulders for allowing viscous flow past the wiper when the flow tube is moved between the first and second axial positions.

Abstract: A remotely operated abrasive blasting apparatus is provided. Systems incorporating the apparatus, and methods of treating surfaces using the apparatus and systems are also provided. The abrasive blasting apparatus eliminates the need for human operators to be present in the area being treated, and allows areas inaccessible to human operators to be treated.

Abstract: The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.