Abstract: A flow tube is axially moveable within an actuator body between a first axial position and a second axial position for actuating a downhole tool, such as for closing a subsurface safety valve. The flow tube includes an interior flow bore for conveying fluids from the tubing string through the actuator body. An external flow tube profile defined on the flow tube includes an upper shoulder for engagement with a wiper in the first axial position, a lower shoulder for engagement with the wiper in the second axial position, and a clearance path between the upper and lower shoulders for allowing viscous flow past the wiper when the flow tube is moved between the first and second axial positions.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using data format conversion (e.g., of output(s) from generative design processes) and user interface techniques that facilitate the production of 3D models of physical structures that are readily usable with 2.5-axis subtractive manufacturing, include: modifying smooth curves, which have been fit to contours representing discrete height layers of an object, to facilitate the 2.5-axis subtractive manufacturing; preparing an editable model of the object using a parametric feature history, which includes a sketch feature, to combine extruded versions of the smooth curves to form a 3D model of the object in a boundary representation format; reshaping a subset of the smooth curves responsive to user input with respect to the sketch feature; and replaying the parametric feature history to reconstruct the 3D model of the object, as changed by the user input.

Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Abstract: An object detection system includes a first camera having a first field of view and a second camera having a second field of view that overlaps with the first field of view. The object detection system includes object detection logic configured to receive a first image from the first camera and a second image from the second camera and identify an object in both the first and second image. The object detection system further includes object mapping logic configured to identify a location of the object based on the first and second image. The object detection system also includes display logic configured to display the location of the object.

Abstract: Systems and methods for efficiently processing electronically stored information (ESI) are described. The systems and methods describe processing ESI in preparation for, or association with, litigation. The invention preserves the contextual relationships among documents when processing and indexing data, allowing for increased precision and recall during data analytics.

Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: Systems and apparatus are provided for monitoring and/or collecting data regarding environmental conditions and optionally personal health information, and generating warnings for a wearer based on acceptable limits for hazards. Using the collected data, the systems and apparatus communicate recommendations to the wearer to improve or maintain personal safety in the detected environment. Methods for monitoring environmental risks and generating warnings based on acceptable limits for hazards are also provided.

Abstract: Embodiments relate to systems, methods and devices for delivering a drug or other therapy to a patient with an ambulatory infusion pump configured to provide a series of tolerance-building steps leading up to a plateau delivery rate. The plateau delivery rate is maintained until the prescribed amount of drug or therapy fluid is delivered to the patient. Embodiments of the invention include providing the patient or other user with a mechanism to decrease, or step down, the therapy delivery rate if a tolerance was not achieved at a lower rate, and providing notifications prior to a step up in a dosage delivery rate.

Abstract: A cover device may include a body with an inner surface and an outer surface, each of the inner surface and the outer surface extending from a first end face of the body to a second end face of the body. The inner surface may define a channel extending through the body from the first end face to the second end face. The body may define a plurality of grooves extending from the first end face to the second end face. Portions of each groove may be defined by the inner surface, the first end face, the outer surface, and the second end face. Each of the body, the inner surface, and the outer surface may be configured to elastically deform relative to at least an axis of the channel.

Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for efficiently processing electronically stored information (ESI) are described. The systems and methods describe processing ESI in preparation for, or association with, litigation. The invention preserves the contextual relationships among documents when processing and indexing data, allowing for increased precision and recall during data analytics.

Abstract: A cover device may include a body with an inner surface and an outer surface, each of the inner surface and the outer surface extending from a first end face of the body to a second end face of the body. The inner surface may define a channel extending through the body from the first end face to the second end face. The outer surface may define a plurality of grooves extending from the first end face to the second end face. Each of the body, the inner surface, and the outer surface may be configured to elastically deform relative to at least an axis of the channel.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: A device for heating and quenching a tubular member has a central axis. The device includes a first quenching ring, a second quenching ring axially spaced from the first quenching ring, and a heating ring axially positioned between the first quenching ring and the second quenching ring. Each quenching ring and the heating ring is configured to receive the tubular member. The heating ring is fixably coupled to the first quenching ring and the second quenching ring. The heating ring includes an induction coil configured to heat an annular target zone along the tubular member. The first quenching ring is configured to deliver a first quenching fluid to the target zone and a first annular heat affected zone along the tubular member, and the second quenching ring is configured to deliver a second quenching fluid to the target zone and a second annular heat affected zone along the tubular member.

Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.