Abstract: Systems and methods for efficiently processing electronically stored information (ESI) are described. The systems and methods describe processing ESI in preparation for, or association with, litigation. The invention preserves the contextual relationships among documents when processing and indexing data, allowing for increased precision and recall during data analytics.

Abstract: A target marking system includes a light source configured to emit a beam of thermal radiation and to impinge the beam onto a target. The system also includes a detector configured to collect radiation passing from the target to the detector along a path. The radiation passing from the target in response to impingement of the beam onto the target. The system further includes an optics assembly disposed optically upstream of the detector along the path. The optics assembly includes at least one of an afocal power changer, a camera objective, a catadioptric lens, and a zoom system configured to condition the radiation passing from the target to the detector.

Abstract: A target marking system includes a light source configured to emit a beam of thermal radiation and to impinge the beam onto a target. The system also includes a detector configured to collect radiation passing from the target to the detector along a path. The radiation passing from the target in response to impingement of the beam onto the target. The system further includes an optics assembly disposed optically upstream of the detector along the path. The optics assembly includes at least one of an afocal power changer, a camera objective, a catadioptric lens, and a zoom system configured to condition the radiation passing from the target to the detector.

Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for efficiently processing electronically stored information (ESI) are described. The systems and methods describe processing ESI in preparation for, or association with, litigation. The invention preserves the contextual relationships among documents when processing and indexing data, allowing for increased precision and recall during data analytics.

Abstract: A target marking system includes a light source emitting a thermal beam and an optics assembly directing the thermal beam to impact a target, the target directing radiation to the optics assembly in response to the impact. The target marking system further includes a detector, and an optics assembly optically connected to the detector.

Abstract: A target marking system includes a light source emitting a thermal beam and an optics assembly directing the thermal beam to impact a target, the target directing radiation to the optics assembly in response to the impact. The target marking system further includes a detector, and an optics assembly optically connected to the detector.

Abstract: A target marking system includes a light source configured to emit a beam of thermal radiation and to impinge the beam onto a target. The system also includes a detector configured to collect radiation passing from the target to the detector along a path. The radiation passing from the target in response to impingement of the beam onto the target. The system further includes an optics assembly disposed optically upstream of the detector along the path. The optics assembly includes at least one of an afocal power changer, a camera objective, a catadioptric lens, and a zoom system configured to condition the radiation passing from the target to the detector.

Abstract: A contact element (1) for providing an electrical contact between a first electrical device (7) and a second electrical device, wherein the contact element (1) comprises a first contact portion (2) to be electrically connected to the first electrical device (7) and a second contact portion (4) to be connected to the second electrical device. The first contact portion (2) is arranged at a distance (D) to the second contact portion (4), whereby the contact element (1) comprises further an adjustment portion (3) connecting said first and second contact portion (2, 4), wherein with said adjustment portion (3) said distance (D) between the first contact portion (2) and the second contact portion (4) is adjustable.

Abstract: A target marking system includes a light source emitting a thermal beam and an optics assembly directing the thermal beam to impact a target, the target directing radiation to the optics assembly in response to the impact. The target marking system further includes a detector, and an optics assembly optically connected to the detector.

Abstract: This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.

Abstract: A method for generating a secure application is described herein. The method can include the steps of obtaining a target application and decomposing the target application into original files that contain predictable instructions. One or more predictable instructions in the original files may be identified. In addition, the target application may be modified to create the secure application by binding one or more intercepts to the target application. These intercepts can enable the modification of the predictable instructions in accordance with one or more policies such that the behavior of the secure application is different from the original behavior of the target application. Modification of the target application may be conducted without access to the source code of the target application.

Abstract: A method for generating a secure application is described herein. The method can include the steps of obtaining a target application and decomposing the target application into original files that contain predictable instructions. One or more predictable instructions in the original files may be identified. In addition, the target application may be modified to create the secure application by binding one or more intercepts to the target application. These intercepts can enable the modification of the predictable instructions in accordance with one or more policies such that the behavior of the secure application is different from the original behavior of the target application. Modification of the target application may be conducted without access to the source code of the target application.

Abstract: A method for generating a secure application is described herein. The method can include the steps of obtaining a target application and decomposing the target application into original files that contain predictable instructions. One or more predictable instructions in the original files may be identified. In addition, the target application may be modified to create the secure application by binding one or more intercepts to the target application. These intercepts can enable the modification of the predictable instructions in accordance with one or more policies such that the behavior of the secure application is different from the original behavior of the target application. Modification of the target application may be conducted without access to the source code of the target application.

Abstract: The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a by perproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: A target marking system includes a light source emitting a thermal beam and an optics assembly directing the thermal beam to impact a target, the target directing radiation to the optics assembly in response to the impact. The target marking system further includes a detector, and an optics assembly optically connected to the detector.

Abstract: The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions. The invention also relates to kits for treatment and/or prevention of ischemic lesions, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

Abstract: An apparatus and method of launching and retrieving a ballistically launched delivery device. A replaceable bullet trap with an axial cavity may be inserted into a launch delivery tube. The launch delivery tube may be attached to a ballistic muzzle. A projectile may be fired from the ballistic muzzle through the delivery tube and into the axial cavity of the replaceable bullet trap. An impulse and momentum of mass of the projectile may be transferred from the projectile to the replaceable bullet trap and then to the launch delivery tube to launch the launch delivery tube from the ballistic muzzle.

Abstract: A system and method of adaptively loading a target application is described herein. The method can include the steps of loading an encapsulation application into memory in which the encapsulation application encapsulates the target application and allocating memory for the encapsulated target application. The method can also include the steps of remapping the encapsulated target application into the allocated memory such that the target application is loaded in the memory and configuring the target application to enable calls of the target application to be intercepted by the encapsulation application.