Abstract: Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B3 compound and, optionally, one or more additional skin care actives to provide a skin health and/or appearance benefit. The low-pH composition also includes a pH buffer comprising lactic acid and sodium lactate, a polymer thickener comprising polyacrylate crosspolymer-6, and a silicone fluid having a kinematic viscosity of 100 cSt or less at 25° C. The pH of the low-pH composition can range from 2.0 to 5.0.

Abstract: Provided is a system for analyzing features associated with entities using an embedding tree, the system including at least one processor programmed or configured to receive a dataset associated with a plurality of entities, wherein the dataset comprises a plurality of data instances for a plurality of entities. The processor may be programmed or configured to generate at least two embeddings based on the dataset and determine split criteria for partitioning an embedding space of at least one embedding tree associated with the dataset based on feature data associated with an entity and embedding data associated with the at least two embeddings. The processor may be programmed or configured to generate at least one embedding tree having a plurality of nodes based on the split criteria. Methods and computer program products are also provided.

Abstract: Systems, and methods are described for navigating non-dynamic pages at a client device served up from voice search requests by selecting a feature on the image page by a user request for navigating the feature viewed on the image page wherein the feature selected has an appearance of a dynamic feature when served up on the display wherein the user request selects a location on the image page; identifying the feature by the voice cloud server by location data of a selected location on the page; executing a feature request on a corresponding page which contains dynamic script at the voice cloud server to receive a linked page from a third-party search service; and removing dynamic scripts, at the voice cloud search server, of the linked page for serving up as an image page of the linked page at the client device.

Abstract: A digital to analog converter (DAC) includes an amplifier including a buffer of the DAC, and a resistor ladder arrangement coupled to a non-inverting input terminal of the amplifier to generate a voltage based on a digital control word. The arrangement includes a first, least-significant bit, segment arranged in one of an R-2R or unit-R configuration, a second, most-significant bit, segment including one or more units each including a second-segment-resistor having a resistor terminal coupled to a respective second switch and having a second resistance, RMSB, and a third segment including one or more third-segment-resistors coupled in parallel to the non-inverting input terminal and connected to a first reference voltage terminal. M2 designates a number of bits in the digital control word for controlling the second switches, and the third segment has a total resistance, Rsp, based on M2.

Abstract: A method of object status detection for objects supported by a shelf, from shelf image data, includes: obtaining a plurality of images of a shelf, each image including an indication of a gap on the shelf between the objects; registering the images to a common frame of reference; identifying a subset of the gaps having overlapping locations in the common frame of reference; generating a consolidated gap indication from the subset; obtaining reference data including (i) identifiers for the objects and (ii) prescribed locations for the objects within the common frame of reference; based on a comparison of the consolidated gap indication with the reference data, selecting a target object identifier from the reference data; and generating and presenting a status notification for the target product identifier.

Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: The present invention is directed to inhibitors of Kirsten Rat sarcoma virus (KRAS), and more particularly to compounds of Formula I as well as compositions comprising Formula I and methods of using the compound of Formula I for the treatment or prevention of a disease, disorder, or medical condition mediated through KRAS, especially the KRAS mutant G12C.

Abstract: The present disclosure is directed to engineered nanoparticles/liposomes that inhibit enveloped viruses and methods for use thereof.

Abstract: A method of assessing gut health in a subject is provided. The method involves placing a device on or near the subject's skin and measuring a level of hydrogen gas emanating through the subject's skin. The device includes an electrochemical sensor capable of detecting hydrogen gas and a means of connecting the device to an apparatus having a central processing unit (CPU). The apparatus provides information on hydrogen gas level and the hydrogen gas level is used to assess gut health of the subject.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: This disclosure describes techniques to aggregate sensor data. The techniques perform operations comprising: receiving, from a first sensor, a first profile representing a first set of movement attributes detected by the first sensor in an area at a given point in time; receiving, from a second sensor, a second profile representing a second set of movement attributes detected by the second sensor in the area at the given point in time; computing a similarity measure between the first and second sets of movement attributes of the first and second profiles; determining that the similarity measure exceeds a threshold value; and in response to determining that the similarity measure exceeds the threshold value, associating the first and second profiles with a same first object that is in the area at the given point in time.

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

Abstract: Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.

Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: The present invention relates to the production of steviol glycoside rebaudiosides D4, WB1 and WB2 and the production of rebaudioside M from Reb D4.

Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.

Abstract: Provided is a method for normalizing embeddings for cross-embedding alignment. The method may include applying mean centering to the at least one embedding set, applying spectral normalization to the at least one embedding set, and/or applying length normalization to the at least one embedding set. Spectral normalization may include decomposing the at least one embedding set, determining an average singular value of the at least one embedding set, determining a respective substitute singular value for each respective singular value of a diagonal matrix, and/or replacing the at least one embedding set with a product of the at least one embedding set, a right singular vector, and an inverse of the substitute diagonal matrix. The mean centering, spectral normalization, and/or length normalization may be iteratively repeated for a configurable number of iterations. A system and computer program product are also disclosed.

Abstract: A method for factory calibration of a sensor of a CGM system is disclosed. A processor receives an enzyme membrane thickness after each dip of a working wire according to first parameters. The processor receives a glucose limiting membrane thickness after each dip of the working wire according to second parameters. The processor determines a working wire diameter, and includes the membrane thicknesses. The processor in communication with the CGM system, automatically generates a correlation between the first and the second parameters to at least one of a factory sensitivity and a drift profile. The drift profile predicts a sensitivity of the sensor over time. The processor associates the at least one of the factory sensitivity or the drift profile with the sensor. The sensor outputs a glucose reading during in-vivo use based on the at least one of the factory sensitivity or the drift profile.

Abstract: A coated substrate comprising a coating extending over at least a part of the substrate. The coating is obtainable from a coating composition comprising (a) a polymeric binder; and (b) a feathering reducing agent comprising a carboxylic acid reactive functional group. The coated portion of the substrate comprises a pretreatment layer. The pretreatment layer is obtainable from a pretreatment composition that comprises a trivalent chromium compound. The invention extends to a method of coating a pre-treated substrate and a coated package, such as a metal can.

Abstract: Methods, apparatus, and systems are described for improved edge network access for a UE. According to some aspects, a UE may receive a first Data Network Name (DNN) from an application and determine, based on a Data Network Name (DNN) Replacement Rule, the first DNN is associated with a second Data Network Name (DNN), where the first DNN and the second DNN are different. The UE may determine, based on the DNN Replacement Rule, to associate traffic from the application with a Protocol Data Unit (PDU) Session, where the PDU Session may be used to send data from the application to a network and the PDU Session is associated with the second DNN.