Abstract: A method, apparatus, and system for object detection on an edge device include projecting a hyperdimensional vector of a query request for an image received at the edge device into a hyperdimensional embedding space to identify at least one exemplar in the hyperdimensional embedding space having a predetermined measure of similarity to the query request using a network trained to: generate a respective hyperdimensional image vector and a respective hyperdimensional text vector for the image and received text descriptions of the image, generate a hyperdimensional query text vector of the query request, combine and embed respective ones of the hyperdimensional image vectors and the hyperdimensional text vectors into a hyperdimensional embedding space to generate respective exemplars, project the hyperdimensional query text vector into the hyperdimensional embedding space, and determine a similarity measure between the hyperdimensional query text vector and at least one of the respective exemplars.

Abstract: Systems and methods for performing document entity extraction are described herein. The method can include receiving an inference document and a target schema. The method can also include generating one or more document inputs from the inference document and one or more schema inputs from the target schema. The method can further include, for each combination of the document input and schema input, obtaining one or more extraction inputs by generating a respective extraction input based on the combination, providing the respective extraction input to the machine-learned model, and receiving a respective output of the machine-learned model based on the respective extraction. The method can also include validating the extracted entity data based on reference spatial locations and inference spatial locations and outputting the validated extracted entity data.

Abstract: Various systems, devices, storage media, and methods are discussed for performing secured access service edge (SASE) processing in a network potentially having multiple SASE processing capable devices.

Abstract: A handheld device for applying mechanical vibration to a body portion of an individual to treat a condition of the individual, includes: a housing; a member having an exterior surface for contacting the individual, the member configured to oscillate to apply the mechanical vibration to the body portion; and a motor in the housing, the motor configured to cause the member to oscillate at an oscillation frequency for inducing tear production or a sinus effect; wherein the handheld device has an operational sound level that is 40 dB or less.

Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: Disclosed herein are an apparatus, system, and method directed for an autonomous wellbore cleaner. In one embodiment, an apparatus for cleaning a wellbore, the apparatus comprising: an autonomous robot, wherein the robot is self-propelled; a power source for the robot; a motor for propelling the robot axially within the wellbore; at least one cleaning tool positioned on the robot; at least one sensor to detect an initiate-cleaning attribute downhole in the wellbore; and a processor to direct the robot to initiate a cleaning operation in response to the initiate-cleaning attribute exceeding a threshold.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: In aspects of the present disclosure, a circuit interrupter includes a housing, a conductive path, a switch which selectively interrupts the conductive path, sensor(s), memory, and a controller within the housing. The sensor(s) measure electrical characteristic(s) of the conductive path. The memory stores an arc detection program that implements a machine learning model and includes a field-updatable program portion and a non-field-updatable program portion, where the field-updatable program portion includes program parameters used by the non-field-updatable program portion to decide between presence or absence of an arc fault. The controller executes the arc detection program to compute input data for the machine learning model based on the sensor measurements, decide between presence of an arc event or absence of an arc event based on the input data, and cause the switch to interrupt the conductive path when the decision indicates presence of an arc event.

Abstract: The disclosure relates to an abrasive article comprising: a fabric substrate comprising strands forming first void spaces between the strands; a laminate joined to the fabric substrate; a cured resin composition joined to the laminate opposite the fabric substrate; abrasive particles joined to the cured resin composition; and a plurality of second void spaces extending through the laminate coinciding with first void spaces in the fabric substrate. The disclosure also relates to methods of making such abrasive articles.

Abstract: Methods for processing deposited metal nanowire inks with metal ions are used to form fused metal nanostructured networks. The metal nanowire inks include a hydrophilic polymer binder, such as a cellulose based binder. The metal nanowire inks can be deposited onto a substrate surface and dried to drive the fusing process. Transparent conductive films can be formed with desirable properties.

Abstract: The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of creating refractory coatings with controlled porosity. Refractory coatings can be formed from refractory metal, metal oxide, or metal/metal oxide composite refractory coating precursor of the 9 refractory metals encompassed by groups 4-6 and periods 4-6 of the periodic table; non-metallic elements (e.g. Si & B) and their oxides (i.e. SiO2 & B2O3) are also pertinent. The conversion of the refractory coating precursor to refractory carbide, nitride or boride is achieved via carburization, nitridization, or boridization in the presence of carbon-containing (e.g. CH4), nitrogen containing (e.g. NH3), and boron-containing (e.g. B2H6) gaseous species. Any known technique of applying the refractory coating precursor can be used.

Abstract: A discoverer user equipment sends a discovery announcement to a discoveree user equipment via a sidelink service. The announcement includes criteria for a service sought by discoverer. The discoveree assesses the announcement and may respond to the discoverer. The discovery announcement may be a target search discovery announcement or a self-advertisement discovery announcement, and may be unicast, groupcast, or broadcast. The discoverer and discoveree may perform synchronization in support of V2X sidelink communication and may collect driving information pertaining to vehicles associated with the discoverer and discoveree, respectively, such as driving intention, positioning, and environment information. The discoverer may request an authorization for the discovery announcement, and the request may include the driving information.

Abstract: Provided herein are EphA2 antibodies. These EphA2 antibodies bind preferentially to tumor tissue than normal tissue and bind to EphA2. Such antibodies are used in methods of inducing an immune response and methods of inhibiting tumor cell growth. Additionally provided are methods of producing such antibodies.

Abstract: A display system may comprise an array of pixels arranged to display an image and one or more imaging sensors. Each imaging sensor may be arranged with at least one pixel of the array. The display system may further comprise at least one communication line to provide an image to the array of pixels and to output the sensed data of the plurality of imaging sensors. The display system may further comprise an array of non-visible light quantum dots. The array non-visible light quantum dot may be arranged with the array of pixels such that each quantum dot converts light from the array of pixels to emissions in a non-visible light wavelength range. The display system may further comprise a one or more sensor pixels sensitive to light in the non-visible light wavelength range.

Abstract: Crystalline forms of Compound I: pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl) thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.

Abstract: The present invention relates to a method for obtaining a bioactive serum fraction derived from fresh rose flowers (Rosa spp.). The present invention also provides bioactive serum fractions and bioactive extracts derived from fresh rose flowers (Rosa spp.) and compositions comprising the same. The present invention further relates to a method of cosmetic treatment for improving skin appearance associated with antioxidant and antiaging properties of the bioactive serum fraction and the bioactive extract derived from fresh rose flowers (Rosa spp.).

Abstract: Systems and methods are provided for receiving an input comprising one or more attributes, selecting a subset of query options from a list of query options relevant to the attributes of the input, and based on query optimization results from an audit of previous queries, determining a priority order to execute each query in the set of queries based on the query optimization results, and executing each query in the priority order to generate a candidate list. For each candidate in the list of candidates, systems and methods are provided for selecting a subset of available workflows based on relevance to the candidate and based on workflow optimization results, determining an order in which the selected subset of workflows is to be executed, and executing the selected subset of workflows in the determined order to generate a match score indicating the probability that the candidate matches the input.

Abstract: One embodiment of the present invention sets forth a technique for inserting content into a media program. The technique includes determining a plurality of markers corresponding to a plurality of locations within a media program. The technique also includes for each marker included in the plurality of markers, automatically analyzing a first set of intervals within the media program that lead up to the marker and a second set of intervals within the media program that immediately follow the marker and determine a set of audio characteristics associated with the first set of intervals and the second set of intervals. The technique further includes generating a plurality of scores for the plurality of markers based on the set of audio characteristics for each marker and inserting additional content at one or more markers included in the plurality of markers based on the plurality of scores.