Abstract: Systems and methods of the present disclosure are directed to a method for predicting semantic similarity between documents. The method can include obtaining a first document and a second document. The method can include parsing the first document into a plurality of first textual blocks and the second document into a plurality of second textual blocks. The method can include processing each of the plurality of first textual blocks and the second textual blocks with a machine-learned semantic document encoding model to obtain a first document encoding and a second document encoding. The method can include determining a similarity metric descriptive of a semantic similarity between the first document and the second document based on the first document encoding and the second document encoding.

Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

Abstract: Embodiments herein describe optical devices that include focusing elements in or on a substrate on which a laser source is disposed. That is, the focusing element can be arranged on a same surface of the substrate as the laser source. In one embodiment, the laser source emits an optical signal that is parallel with the same surface of the substrate. A turning mirror can be used to direct the optical signal in a direction perpendicular to the surface so that the optical signal is incident on the focusing element.

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.

Abstract: The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.

Abstract: Sensors and methods for determining the state of charge of a battery are described. The state of charge is determined in some instances by applying a current perturbation having a frequency to the battery terminals, monitoring the response signal, and determining the phase of the response signal. The phase may be correlated to the state of charge of the battery, so that once the phase is determined, a determination of the state of charge of the battery may be made. In some situations, the state of charge may be used to determine the operating condition of a load connected to the battery. In some embodiments, the state of charge may be used to determine whether the battery is defective.

Abstract: The present disclosure provides compositions comprising enzyme-based reagents, and methods using the enzyme-based reagents, for nucleic acid sequencing. The enzyme-based reagents efficiently remove sequencing read products from a first sequenced region of a template molecule, thereby reducing residual signals in a second sequenced region on the same template molecule.

Abstract: A homogenous mixing apparatus is provided that includes a circulation unit, a dynamic mixing unit, wherein a feeding port of the first-stage dynamic mixing device communicates with the discharging end of the circulation unit, a discharging port of the third-stage dynamic mixing device communicates with the feeding end of the circulation unit, and each of the dynamic mixing devices includes a dynamic mixer; and a control unit, configured to be capable of controlling the dynamic mixing unit, so that the dynamic mixers of the first-stage, second-stage, and third-stage dynamic mixing device are capable of being independently started and shut down and operated at independent rotating speeds, wherein the dynamic mixers each includes a stator and a rotor, rotating speed ranges of the dynamic mixers of the first-stage, second-stage, and third-stage dynamic mixing device increase in sequence, and distances between the rotors and the stators decrease in sequence.

Abstract: A bathtub device for bubble bath physiotherapy, wherein the bathtub body is mounted on the bathtub body support. The exhaust system of the bathtub device is mounted in a space between the bathtub body and the bathtub body support. A fan is configured for delivering gas. The air suction inlet ends of the air suction pipe are configured to be in communication with the upper open side of the bathtub body, and the air suction outlet end is connected to the air inlet side interface device of the fan. The exhaust inlet end of the exhaust pipe is connected to the air outlet side interface device of the fan. The present invention further provides a bubble bath physiotherapy system comprising the bathtub device. By using the bathtub device, a safer bubble bath can be achieved.

Abstract: Phospholipid-conjugated Ags were used as an agnostic delivery platform to cell type, activation state, and inherent uptake capabilities for engineering APCs to control Ag-specific cellular immune responses. Lipid-mediated delivery (termed depoting) of MHC class I and II-restricted Ags successfully loaded resting polyclonal B cells, CD40? activated B cells, and DCs in a dose-dependent manner for priming Ag-specific CD8+ and CD4+ T cells, respectively. When lipid-conjugated Ags were paired with polymer-conjugated Ags and incorporated in nanoparticles (NPs), diverse APCs with varying NP internalization capabilities all processed the lipid-conjugated Ags via depoting while only DCs processed the PLGA-conjugated Ags via endocytosis. Multivariate analyses of cytokine secretions indicated that lipid-conjugated Ags could be distinctly classified from polymer-conjugated Ags.

Abstract: The invention relates to a non-invasive imaging method of bacteria. One embodiment comprises labeling the bacteria with a radioisotope, then delivering it to the gut of a human or animal. Another embodiment is to label bacteriophages, then administer them to a human or animal, so that they infect (and thus co-localize with) bacteria already resident in the human or animal. The bacteriophage can then be imaged, showing the location of the resident bacteria of interest. In another embodiment, the invention is related more generally to the labelling of bacteria or bacteriophages with a radio-metal or radioisotope to render the labeled gut bacteria and the bacteria in the body visible to nuclear medicine PET and SPECT imaging guided by functional/structural MRI and/or CT imaging.

Abstract: A homogenous mixing apparatus comprises: a circulation unit, a dynamic mixing unit, wherein a feeding port of the first-stage dynamic mixing device communicates with the discharging end of the circulation unit, a discharging port of the third-stage dynamic mixing device communicates with the feeding end of the circulation unit, and each of the dynamic mixing devices comprises a dynamic mixer; and a control unit, configured to be capable of controlling the dynamic mixing unit, so that the dynamic mixers of the first-stage, the second-stage dynamic mixing device, and the third-stage dynamic mixing device are capable of being independently started and shut down and operated at independent rotating speeds, wherein the dynamic mixers each comprise a stator and a rotor, rotating speed ranges of the dynamic mixers of the first-stage, second-stage, and third-stage dynamic mixing device increase in sequence, and distances between the rotors and the stators decrease in sequence.

Abstract: The present disclosure relates to method, storage medium and electronic device for detecting vehicle crashes. The method comprises: acquiring state information of a target vehicle; and determining an event type of the target vehicle according to the state information and a trained convolutional neural network, the event type being any of the following types: a crash event, a near crash event and a baseline event. The event type of the vehicle is determined using the trained convolutional neural network in the present disclosure, so that the accuracy is high; and near crash events can be detected, thus, when a near crash event is detected, the driver can be further alerted or an evading operation is directly performed on the vehicle, so that the safety is improved and the safety of the driver and passengers is guaranteed.

Abstract: Opioids can be detected using a test system with ZnO pillars arranged in an array on a silicon wafer. Silver particles are on a top surface and/or side surface of the ZnO pillars. A sample fluid is applied to the test system. A concentration of an opioid compound in the sample fluid is determined using Surface-Enhanced Raman Spectroscopy of the test system. The sample fluid can be blood or a fluid isolated from blood.

Abstract: A bathtub device for bubble bath physiotherapy, wherein the bathtub body is mounted on the bathtub body support. The exhaust system of the bathtub device is mounted in a space between the bathtub body and the bathtub body support. A fan is configured for delivering gas. The air suction inlet ends of the air suction pipe are configured to be in communication with the upper open side of the bathtub body, and the air suction outlet end is connected to the air inlet side interface device of the fan. The exhaust inlet end of the exhaust pipe is connected to the air outlet side interface device of the fan. The present invention further provides a bubble bath physiotherapy system comprising the bathtub device. By using the bathtub device, a safer bubble bath can be achieved.

Abstract: The present disclosure relates to a vehicle tracking method, a computer readable storage medium, and an electronic device. The method includes: determining a predicted value of state information of a target tracking vehicle based on a sequential Kalman filtering model according to a most recently acquired tracking value of the state information of the target tracking vehicle, wherein the state information at least includes location information; obtaining a detected value of the state information of the target tracking vehicle; and in response to the obtained detected value, acquiring a new tracking value of the state information of the target tracking vehicle based on the sequential Kalman filtering model according to the detected value and the most recently determined predicted value. Through the above technical solution, the tracking value of the state information of the target tracking vehicle may be determined more accurately.

Abstract: The present disclosure relates to a target object detection method, a readable storage medium and an electronic device. The method is periodically executed and the method includes: identifying a target object based on first N frames of image data obtained within a current execution period, wherein N is a positive integer, and N is less than the total number of frames of image data that can be obtained within the current execution period; and if the target object is identified, tracking the target object based on the obtained image data within the remaining time period of the current execution period. In the above technical solution, when the target object is identified, the identified target object is tracked within the remaining time period of the current execution period, so that the data calculation amount can be effectively reduced.

Abstract: The present disclosure relates to a method, a computer readable storage medium and electronic equipment for analyzing driving behavior. The method comprises: acquiring image information in a running process of a target vehicle; acquiring time series data in the running process according to the image information; and acquiring a target driving behavior score for the running process according to the time series data.