Abstract: The present invention provides a cyclic lipopeptide acrylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.

Abstract: In a pipe forming process using bending rolls, load applied to an upper roll is reduced to suppress the deflection of the upper roll, thereby suppressing creation of large end gap at the longitudinal center of the pipe, thus enabling production of high-strength, thick-walled elongated pipes. This is achieved either by (1) setting the roll spacing L between lower rolls to a value greater than the sum of the diameter Dwu of the upper roll 34 and the diameter Dwl of each of the lower rolls 32, and setting the amount S of tightening of the upper roll 34 with respect to the lower rolls 32 to a value greater than the radius Rwl of each of the plural rolls; or by (2) effecting pipe forming work on the sheet material such that the spacing L of the lower rolls 32 satisfies the following condition: (Dp+Dwl)>L≧0.

Abstract: There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase.

Abstract: A process for producing a compound of the general formula (I): (wherein R1 represents hydrogen, a lower alkanoyl group or a lower alkyl group; R2 and R3each represents hydrogen or a lower alkanoyl group) characterized in that a compound of the general formula (II): (wherein R1, R2 and R3 are respectively as defined above) is reacted with a culture of a strain of microorganism belonging to the genus Fusarium or its cells harvested by filtering the broth.

Abstract: The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compound which comprises the use of said acylase.

Abstract: The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.

Abstract: It is an object of the present invention to provide a fire resistance bond magnet having superior temperature properties and most suitable for convergence use in picture tubes for display and high precision television, and alloy powders for bond magnet, without containing Co which is restricted in resources. The flame retardancy bond magnet having superior temperature properties and most suitable for convergence use in picture tubes for display and high precision television can be provided at low cost without containing Co, by using the alloy powders for bond magnet consisting of Al-Ni-Cu-(Ti, Nb)-Fe without Co, and having an isotropy and mean particle sizes of 10 .mu.m to 200 .mu.m, and kneading, molding and curing the 20 wt % to 80 wt % alloy powders together with a chlorine flame retardant, a flame retardant assistant such as antimony trioxide and zinc boric acid and a binder.

Abstract: The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.

Abstract: A method for controlling edge drop in a cold rolling operation adaptable to tandem cold rolling mill stands by shifting a pair of vertically disposed single-end-tapered work rolls along the widthwise direction of a steel strip. The work rolls have tapered end portions that are disposed on the two widthwise ends of the steel strip.

Abstract: A wet skin-pass rolling method for rolling a steel sheet by a mill while adjusting the hardness of said steel sheet through control of the rolling reduction. The method comprises determining an allowable range of reduction ratio from a predetermined desired range of hardness of the product, determining a command delivery-side sheet thickness to be obtained at the delivery side of the mill on the basis of the sheet thickness measured at the entry side of the mill, and adjusting the sheet thickness control in accordance with the command delivery-side sheet thickness.

Abstract: This invention relates to a method for promoting the growth of growing animals with compounds selected from WS-1627A; WS-1627B; WS-1627C and WS-1627D or salts thereof.

Abstract: The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,R.sup.2 is hydroxy, alkoxy, or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof.

Abstract: A method for preventing the camber of a two-layered clad metal sheet having a base layer and a covering layer of different metals which exhibit different amounts of thermal contraction. The method comprises developing a temperature difference .DELTA. T expressed by the following formula between the base layer and the covering layer during a hot levelling, by providing a greater cooling effect before or during levelling to the layer which exhibits the greater thermal contraction than to the layer which exhibits the smaller thermal contraction:.DELTA.T=f (.DELTA..alpha., .alpha., a, To)where,.DELTA..alpha.: the difference in thermal expansion coefficient between both metalsa: the clad ratio (ratio of covering layer thickness to total sheet thickness)To: hot leveller inlet temperature (.degree.C.).alpha.: mean thermal expansion coefficient of both metals.

Abstract: A biologically pure culture of Streptomyces sandaensis which is capable of producing an antitumor and antimicrobial compound, designated FR-900482 substance, is disclosed.

Abstract: New tetracyclo compounds of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy or substituted iminomethyl,R.sup.2 is hydroxy, alkoxy or protected hydroxy,R.sup.3 is hydrogen and R.sup.4 is methyl, hydroxymethyl or protected hydroxymethyl, orR.sup.3 and R.sup.4 are combined together to form methylene or oxo,R.sup.5 is hydroxy, alkoxy or protected hydroxy, andR.sup.6 is hydrogen, imino-protective group or alkyl,and pharmaceutically acceptable salts thereof, which have pharmacological activities such as antitumor activity, antimicrobial activity, and the like, and a process for their production and a pharmaceutical composition containing the same.

Abstract: A sintered Fe-Cr-Co type magnetic alloy consisting essentially of 20-35% Cr, 3-15% Co and the balance substantially of Fe and a method of producing an article made of the alloy are disclosed. The method comprises the steps of blending at least one of an Fe-Cr powder and Fe-Cr-Co powder with a carbonyl Fe-powder and a Co-powder, if necessary to make up to said alloy composition, to provide a powder blend, the average particle size of said Fe-Cr powder and Fe-Cr-Co powder being 200 mesh or smaller in size, and the surface of these powders having been activated; compacting the resulting powder blend to provide a compact; sintering the resulting compact in an atmosphere in which the total amount of oxygen and nitrogen has been restricted to not more than 3 ppm; and effecting the heat treatment and magnetization of the resulting sintered alloy.

Abstract: A caisson for an underwater structure is provided comprising an elongated sponge mat fitted along the outer edge of the base of the frame, said sponge mat being molded from a plastic material and having a skin of a dense foam structure and an interior of a coarse foam structure, a plurality of small holes being provided in said sponge mat so as to extend crosswise, or transversely to the longitudinal direction of the mat, from one side of the mat to the other side, and at least one rope being passed through each of said holes, each of said ropes being of a length equal to or greater than the length of the corresponding small hole.

Abstract: This invention relates to tetrahydrofuran-carboxylic acid derivatives, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is amino or acylamino andR.sup.3 is carboxy or a protected carboxy groupor a pharmaceutically acceptable salt thereof.

Abstract: Prodn. of FR-900129 comprises culturing a Streptomyces n. 4012 category which is analogous to Streptomyces misakiensis and Steptomyces aburaviensis, i.e. Streptomyces avellaneus No. 4012, at 25.degree. C. to 30.degree. C. during 50 to 100 hours in a culture medium which consists of a carbon source (e.g. glucose, fructose, glycerin, starch, galactose, maltose, dextrin), an organic or inorganic nitrogen source (e.g. yeast extract, peptone, cottonseed cake, soyabean powder, cornsteep liquor, dry yeast, ammonium nitrate, ammonium sulphate, ammonium phosphate, urea and amino acid) and an inorganic salt (e.g. calcium carbonate, sodium phosphate, potassium phosphate, sodium chloride, potassium chloride, magnesium salt and copper salt). The produced FR-900129 is isolated by a collecting step, a purifying step, a vacuum condensation step, a freeze-drying step, a pH adjusting step, a cationic, anionic or nonionic resin treating step, an active carbon adsorption step and a crystallizing and recrystallizing step.