Abstract: Provided are polyaniline coordinated with a transition metal, a core-shell nanoparticle including the same as a core, and preparation methods thereof. According to the polyaniline coordinated with a transition metal and the nanoparticle of the present application, it is possible to prepare polyaniline coordinated with a transition metal using an oxidizing agent having a core-shell structure and including the transition metal and a nanoparticle including the same as a core. The polyaniline prepared as such is in a doped state, and, thus, a preparation process is simple. Further, dispersibility with respect to a solvent is improved, and a band gap level of the polyaniline can be easily regulated.

Abstract: A method and an apparatus for diagnosing a brain tumor in real-time are disclosed. A method for detecting a brain tumor in real-time can comprise the steps of: generating, by a probe, a plurality of input signals and transferring the same to a target detection region which is estimated to be the location of a brain tumor; receiving, by the probe, a plurality of reflection signals on the basis of a plurality of input signals; and detecting, by the probe, a plurality of the received reflection signals, wherein a plurality of the input signals comprise a terahertz signal, an optical coherence tomography (OCT) signal, and a Raman signal, and a plurality of the reflection signals can be used for generating a plurality of image information for detecting the location of a brain tumor; and an apparatus for diagnosing a brain tumor in vitro and in real-time, can be used to diagnose, in real-time, a brain tumor specimen, which is extracted from the brain.

Abstract: A preparation method for a magnetic composite for treating and diagnosing cancer. The method may include a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated polymer. The preparation method for a magnetic composite can produce a magnetic composite economically and efficiently because a magnetic composite comprising a magnetic nanoparticle coated with a conjugated polymer can be prepared by a single process.

Abstract: A method in an electronic device is provided, the method including: connecting to a storage device; transmitting a first file to the storage device; when the first file is transmitted to the storage device, generating, a second file based on the first file and replacing the first file with the second file, wherein the second file is an optimized version of the first file.

Abstract: The present invention relates to an amphiphilic nanoparticle specific to a biomarker, and more particularly, provides an amphiphilic nanoparticle which may be used as a diagnosis or treatment-type drug or gene carrier by selectively recognizing a proteolytic enzyme specifically expressed in a cellular membrane of a specific cell, and then being bound to the proteolytic enzyme to efficiently achieve the intracellular uptake and selective cleavage. The amphiphilic nanoparticle of the present invention may be used in the diagnosis or therapy of a disease.

Abstract: The present invention relates to an amphiphilic nanoparticle specific to a biomarker, and more particularly, provides an amphiphilic nanoparticle which may be used as a diagnosis or treatment-type drug or gene carrier by selectively recognizing a proteolytic enzyme specifically expressed in a cellular membrane of a specific cell, and then being bound to the proteolytic enzyme to efficiently achieve the intracellular uptake and selective cleavage. The amphiphilic nanoparticle of the present invention may be used in the diagnosis or therapy of a disease.

Abstract: A preparation method for a magnetic composite for treating and diagnosing cancer. The method may include a step of pyrolyzing a precursor of a magnetic nanoparticle in the presence of a conjugated polymer. The preparation method for a magnetic composite can produce a magnetic composite economically and efficiently because a magnetic composite comprising a magnetic nanoparticle coated with a conjugated polymer can be prepared by a single process.

Abstract: The present invention relates to a system and a method for providing a data analysis service in a cloud environment which does not need to transmit data to an analysis section from a file storage section when providing an analysis service about big data. According to the present invention, it is not needed to specifically move files when analyzing big data, by using the storage section resource in a virtual machine in a cloud environment as storages, and accordingly, the analysis time can be considerably reduced.

Abstract: The present invention relates to a method for separating multiple biological materials using characteristics of magnetic nanoparticles. The method of the present invention is able to separate multiple biological materials at once due to differences in trajectory in an external magnetic field of the same intensity after attaching magnetic nanoparticles to the biological materials to be separated using differences in magnetic susceptibility or magnetization depending on compositions of the magnetic nanoparticles.

Abstract: A method for fabricating a semiconductor device includes sequentially forming an interlayer insulating layer and a hard mask pattern including a first opening on a substrate including a lower pattern, forming a trench exposing the lower pattern in the interlayer insulating layer using the hard mask pattern, forming a liner layer including a first part formed along sidewalls and a bottom surface of the trench and a second part formed along a top surface of the hard mask pattern, forming a sacrificial pattern exposing the second part of the liner layer in the trench, removing the second part of the liner layer and the hard mask pattern using the sacrificial pattern, and after the removing of the hard mask pattern, removing the sacrificial pattern to expose the first part of the liner layer.

Abstract: The present invention relates to a otitis media diagnosis system using terahertz electromagnetic waves, which can diagnose otitis media using terahertz electromagnetic waves in a non-invasive manner, and which can accurately diagnose otitis media by acquiring images on the tympanic cavity using terahertz electromagnetic waves with excellent transmittance, and which can quickly and accurately divide exudative otitis media and suppurative otitis media using terahertz electromagnetic waves that are sensitive to moisture, and which is safe to a body using terahertz electromagnetic waves. The otitis media diagnosis system includes a terahertz probe including a generating unit for radiating terahertz electromagnetic waves from the outside of an ear toward a tympanic cavity and a detection unit for detecting the reflected terahertz electromagnetic waves reflected from the tympanic cavity.

Abstract: Provided are polyaniline coordinated with a transition metal, a core-shell nanoparticle including the same as a core, and preparation methods thereof. According to the polyaniline coordinated with a transition metal and the nanoparticle of the present application, it is possible to prepare polyaniline coordinated with a transition metal using an oxidizing agent having a core-shell structure and including the transition metal and a nanoparticle including the same as a core. The polyaniline prepared as such is in a doped state, and, thus, a preparation process is simple. Further, dispersibility with respect to a solvent is improved, and a band gap level of the polyaniline can be easily regulated.

Abstract: The present invention relates to a nanoparticle including a hydrophobic drug conjugated to a cationic polymer and a hydrophilic drug conjugated to an anionic polymer, a method of preparing the same and a pharmaceutical use thereof. The nanoparticle according to an embodiment of the present invention may deliver the hydrophilic drug and the hydrophobic drug at the same time, and may control an initial drug burst. Further, the nanoparticle according to an embodiment of the present invention is specific to a cancer cell environment, and thus selective diagnosis or treatment of cancer cells is possible.

Abstract: A method for fabricating a semiconductor device includes sequentially forming an interlayer insulating layer and a hard mask pattern including a first opening on a substrate including a lower pattern, forming a trench exposing the lower pattern in the interlayer insulating layer using the hard mask pattern, forming a liner layer including a first part formed along sidewalls and a bottom surface of the trench and a second part formed along a top surface of the hard mask pattern, forming a sacrificial pattern exposing the second part of the liner layer in the trench, removing the second part of the liner layer and the hard mask pattern using the sacrificial pattern, and after the removing of the hard mask pattern, removing the sacrificial pattern to expose the first part of the liner layer.

Abstract: The present invention relates to a novel system for predicting a prognosis capable of predicting the prognosis of locally advanced gastric cancer, and more specifically, capable of predicting a clinical result after a resection during gastric cancer surgery through gene set enrichment comparative analysis.

Abstract: The present invention relates to a novel model for predicting a prognosis capable of predicting the prognosis of gastric cancer, and more specifically, to manufacturing a prediction model for predicting a clinical result after a resection during gastric cancer surgery through genetic mutation comparative analysis.

Abstract: The present invention relates to a nanoparticle including a hydrophobic drug conjugated to a cationic polymer and a hydrophilic drug conjugated to an anionic polymer, a method of preparing the same and a pharmaceutical use thereof. The nanoparticle according to an embodiment of the present invention may deliver the hydrophilic drug and the hydrophobic drug at the same time, and may control an initial drug burst. Further, the nanoparticle according to an embodiment of the present invention is specific to a cancer cell environment, and thus selective diagnosis or treatment of cancer cells is possible.

Abstract: A bioenvironment-sensitive nanoparticle including a polymer having complementary charges, a method of manufacturing the same, and a pharmaceutical use of the bioenvironment-sensitive nanoparticle are disclosed. The bioenvironment-sensitive nanoparticle can be useful in stably and effectively delivering a target material such as a drug even when used at a small quantity since the nanoparticle is stable in extracellular environments. Also, the bioenvironment-sensitive nanoparticle can be useful in selectively diagnosing or treating cancer cells since the nanoparticle is specific to environments of the cancer cells.

Abstract: The present invention relates to DNA aptamer specifically binding to integrin ?v?3, and a composition for diagnosis of cancer or cancer metastasis comprising the same as an active ingredient. And, the present invention relates to a composition for imaging tumor regions comprising the aptamer, and a contrast medium comprising the same.

Abstract: A pH responsive quencher based on a conjugated polymer and responding to an in vivo redox reaction and a preparation method thereof are provided. The pH responsive quencher can evaluate a metabolism environment according to a pH value in vivo with a characteristic that an absorption wavelength band sensitively changes depending on a pH condition.