Abstract: The embodiments of the present disclosure provide a method and apparatus for training an SVM model, a device and a computer-readable storage medium. The method comprises steps of: acquiring a dataset; loading the dataset; predicting the best storage format of the dataset online through an automatic tuning framework, and performing format conversion; and, executing an SMO algorithm to train an SVM model. In this way, the best data storage format and algorithm can be automatically selected according to the input dataset; in a global loop level, a large number of more efficient matrix multiplication operations are performed on the basis of the best data storage format to calculate a kernel matrix; and, in a local SMO solver level, finer memory optimization is performed by the register communication technology and the combined memory access method of the GPU, and the calculation resources of the hardware platform are fully utilized.

Abstract: Provided are a driver and a transmitter. The driver includes: an n-type metal-oxide-semiconductor field-effect transistor differential circuit, a p-type metal-oxide-semiconductor field-effect transistor differential circuit and a power supply. Gate electrodes of the p-type metal-oxide-semiconductor field-effect transistor differential circuit and the n-type metal-oxide-semiconductor field-effect transistor differential circuit receive a first level signal. The p-type and n-type metal-oxide-semiconductor field-effect transistor differential circuits convert the first level signal into a second level signal used by an actuator. Drain electrodes of the p-type and n-type metal-oxide-semiconductor field-effect transistor differential circuits output the second level signal.

Abstract: A central architecture diagram construction method includes obtaining a plurality of pieces of entity information and a relationship between the plurality of pieces of entity information, and then determining first entity information, where the first entity information is one of the plurality of pieces of entity information; constructing a central architecture diagram based on the first entity information and the relationship between the plurality of pieces of entity information, and displaying the central architecture diagram, where a central node in the central architecture diagram indicates the first entity information, the central architecture diagram further includes a plurality of ring layers centered on the central node, each ring layer includes at least one node, and nodes at different ring layers have different relationships with the central node.

Abstract: A spatial omics single cell data acquisition method includes: acquiring a dyeing image of a biological sample, and acquiring a visual gene expression image of the biological sample; registering the dyeing image with the visual gene expression image, so as to obtain a registered image; performing cell segmentation on the registered image, so as to obtain a cell mask image; and according to the cell mask image, determining a cell of a background gene molecule of an unknown cell in the visual gene expression image, and marking the cell, so as to obtain a spatial omics molecular expression matrix with a cell mark. Compared with the prior art, the present disclosure relates to obtaining high-precision spatial single cell data by means of a gene expression matrix diagram, and a processing flow involving splicing, registration, segmentation and correction.

Abstract: Provided in the present application are a compound represented by formula (I), a pharmaceutical composition containing the compound, and the use thereof. The compound represented by formula (I) of the present application has a good effect in terms of inhibiting the activity of HPK1.

Abstract: The application relates to a novel salt of compound (II) and a crystalline form thereof, and to a preparation method for the salt and the crystalline form thereof. Additionally, the application provides a pharmaceutical composition comprising a hydrochloride of compound (II), and an application of the salt in the preparation of a drug used for the prevention and treatment of thrombin-mediated and/or thrombin-related diseases.

Abstract: The present disclosure relates to oligonucleotides, in particular antisense oligonucleotides (ASOs) and pharmaceutically acceptable salts thereof, that can hybridize and reduce the expression of APOE pre-mRNA or mRNA. ASOs disclosed herein can reduce translation of APOE protein in mammals (e.g., humans). The present disclosure further relates to methods of treating a disease or disorder in a subject in need thereof by administration of an antisense oligonucleotide disclosed herein. In particular, methods and ASOs described herein can be used for preventing and/or treating human diseases in which the reduction of APOE amount or its activity would be beneficial, including but not limited to neurodegenerative diseases such as Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and those broadly defined as tauopathies and synucleinopathies.

Abstract: An application device sends a key request packet to a quantum device, where the key request packet includes a user identifier corresponding to the application device, a first public key, and a first message authentication code value. If verification performed on the first message authentication code value succeeds, the quantum device sends a key response packet to the application device, where the key response packet includes a first ciphertext and a second message authentication code value. If verification performed on the second message authentication code value succeeds, the application device decrypts the first ciphertext by using a first private key, to obtain quantum key information allocated by the quantum device to the application device. The first public key and the first private key are from a key pair obtained by the application device by running a post-quantum key generation algorithm.

Abstract: An ultra-precision conformal polishing method based on electrochemical gradient-thickening and vibration-induced micro-motion is provided, the method utilizes an electrochemical gradient-thickening phase to induce electrochemical interfacial reactions that guide a directional motion of charged particles and control a particle aggregation effect of a suspension; and a flexible fluid abrasive tool is then used to generate a vibration-induced microdynamic force in a workpiece direction for efficient conformal material removal. An ultra-precision conformal polishing apparatus based on electrochemical gradient-thickening and vibration-induced micro-motion includes a housing, a conformal polishing device, a power-supply auxiliary device, an electrochemical gradient-thickening polishing suspension conveying device, and a polishing auxiliary device.

Abstract: A multi-objective reinforcement learning-based disassembly line balancing optimization method. By obtaining input data and performing preprocessing, a state space, an action space, and an objective function are constructed; a multi-objective deep Q-network algorithm (MO-DQN algorithm) is adopted to introduce a preference vector to dynamically adjust objective weights, and a model is trained by combining an E-greedy strategy and a non-dominated sorting genetic algorithm II (NSGA-II) to optimize multiple objectives; and an optimal policy generated by the multi-objective reinforcement learning model that is trained is applied to task assignment in an actual disassembly line. The method is capable of dynamically handling objective conflicts, automatically adapting to situational changes, and improving the efficiency of task scheduling and resource allocation.

Abstract: The present disclosure provides a method for generating a small molecule based on a pharmacophore model, a device, and a medium. The method includes: using a fully connected graph to represent a pharmacophore model; using a feature extraction model based on a graph neural network to extract a feature vector of the pharmacophore model from the fully connected graph of the pharmacophore model; performing random sampling on a specified latent variable distribution to obtain a latent variable; and inputting the latent variable and the feature vector of the pharmacophore model to a pre-trained decoder to generate a molecule matching the pharmacophore model, where the pre-trained decoder is a decoder obtained by training a variational autoencoder with training samples.

Abstract: A gene image data correction method and system, an electronic device, and a storage medium are disclosed. The gene image data correction method includes determining a gene molecule density of a target cell based on a count and an initial contour area; determining a background gene molecule density based on a count and a region area of background gene molecules; and determining a cell to which the background gene molecules belong based on the gene molecule density and the background gene molecule density.

Abstract: A display module and an electronic device that includes the display module are provided, which relate to the field of display technologies. The display module can improve unfolding stiffness and bendability and includes a display and a cover plate disposed on a display surface of the display. The display includes at least two bending portions and three non-bending portions to provide a multi-foldable display module having a cover plate designed to be of an unequal-thickness so that the non-bending portion has high rigidity, and the bending portion has favorable bendability.

Abstract: A method and a device for recovering a call service in a mobile communication system are provided. The method includes the following steps determining whether a second cell satisfies a condition for a terminal to perform an IP multimedia subsystem (IMS) registration when detecting that the terminal enters the second cell during a period in which the terminal waits for a next IMS registration due to an IMS registration failure in a first cell, initiating an initial IMS registration when determining that the second cell satisfies the condition, and recovering a call service of the terminal after the initial IMS registration is successful.

Abstract: A cleaning robot includes a first cleaning device and a second cleaning device. The second cleaning device is provided thereon with the antenna enclosure as defined above. The first cleaning device sinks at the bottom of water to clean the bottom of a swimming pool, while the second cleaning device floats on the surface of water to clean the surface of water. The second cleaning device is provided with a first signal cable. A first end of the first signal cable is connected to the antenna enclosure, and a second end of the first signal cable is connected to the first cleaning device. With this arrangement, the antenna enclosure is detachably attached to the second cleaning device, facilitating access to the first signal cable for use and allows replacement by a user with another antenna enclosure optionally with another first signal cable having a different length.

Abstract: Disclosed in contents of the present disclosure are a display panel and a display device, wherein the display panel includes an array substrate (10) and a color film substrate (20) disposed oppositely, and a Liquid Crystal layer (LC) between the array substrate (10) and the color film substrate (20); a liquid crystal cell gap of the Liquid Crystal layer (LC) in a light transmission region of the display panel satisfies: when a refresh rate of the display panel is greater than or equal to 60 Hz and does not exceed 480 Hz, a reciprocal of the refresh rate of the display panel conforms to a quadratic polynomial relationship with the liquid crystal cell gap. The liquid crystal cell gap of the display panel is only related to the refresh rate of the display panel, thereby having more simplified design complexity and higher design efficiency.

Abstract: An electric cleaning apparatus includes a body housing; a battery supported by the body housing; a motor supported by the body housing and electrically connected to the battery; a connecting element connected to the output shaft of the motor directly or indirectly, and a first cleaning assembly, wherein the second cleaning assembly further comprises: an outer housing having at least a inlet and an outlet; a filtering unit arranged in the outer housing; an impeller rotatably arranged in the outer housing, and an impeller connecting member connected to the impeller directly or indirectly, wherein the impeller connecting member can be detachably connected to the connecting element. The present disclosure enables the cleaning apparatus to perform multiple functions.