Publication number: 20260191835
Abstract: Disclosed are combinations comprising a therapeutically effective amount of a menin-MLL inhibitor of Formula (I) or a pharmaceutically acceptable salt or a solvate thereof; and a therapeutically effective amount of at least one other therapeutic agent which is a hypomethylating agent, a cytidine deaminase inhibitor, a DNA intercalating agent, a pyrimidine analog, a purine analog, a kinase inhibitor, a CD20 inhibitor, an IDH inhibitor, an immunomodulatory agent or a DHODH inhibitor. Also disclosed are methods for treating a subject who has been diagnosed with cancer using such combinations. Compounds are represented by Formula (I) as follows: wherein the variables are defined herein.
Type:
Application
Filed:
November 29, 2023
Publication date:
July 9, 2026
Inventors:
Nikki DASKALAKIS,, Diane Christina GUTTKE, Min Chul KWON, Lucille Angela FERRANTE, Kathryn Elizabeth PACKMAN, Eva Christine PIETSCH, Ulrike PHILIPPAR, Sumia ALI-AHMED, Wei CAI, Johannes Wilhelmus J. THURING, Fabian HULPIA, Xuedong DAI, Ming LI, Xiangjun DENG, Chao LIANG, Alicia Tee Fuay NG, Zhen SUN, Zhigao ZHANG, Samuël Dominique DEMIN, Natalia Nikolaevna DYUBANKOVA, Matthieu Dominique JOUFFROY, Susan LEPRI, Nicolas Freddy J DARVILLE, Vineet PANDE, Wim Bert Griet SCHEPENS, James Patrick EDWARDS, Olivier Alexis Georges QUEROLLE
Publication number: 20260193537
Abstract: The present invention discloses a polymerizable compound, a liquid crystal composition comprising the polymerizable compound, and a liquid crystal display device. The polymerizable compound is a compound represented by the following formula I, wherein Sp represents a single bond or a C1-C5 linear, branched or cyclic alkyl group, and the Sp groups are not both single bonds, wherein any one or more non-adjacent —CH2— can be replaced by —O—, —S—, —CO—, —CH2O—, —OCH2—, —COO—, —OOC—, or an acrylate group in such a manner that O- or S-atoms are not directly connected with each other, one or more H atoms can be independently replaced by F, C1, or G3, and at least one H atom is replaced by G3; G3 represents a C1-C7 tertiary alcohol structure; and X represents —CH2—, —O—, or —S—. In particular, the polymerizable compound has the advantages of good diffusivity, high stability of the formed polymer, and low residue after a UV process.
Type:
Application
Filed:
December 22, 2025
Publication date:
July 9, 2026
Applicant:
SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIAL CO., LTD.
Inventors:
Hubo ZHANG, Xin WANG, Pengyao JU, Yongfeng BAO, Renze ZHANG, Ming LI, Jun JIANG, Liangjie ZHANG