Abstract: The present disclosure relates to compounds that are Syk inhibitors or pharmaceutically acceptable salts or co-crystals thereof, and pharmaceutical compositions thereof, and to their use in the treatment of various disease states, including cancer and inflammatory conditions.

Abstract: An LED tube lamp comprises a lamp tube, a first circuit board disposed in the lamp tube having a plurality of light sources mounted thereon, and two lamp caps respectively disposed at both ends of the lamp tube and having a power supply disposed in the lamp caps. The power supply has a second circuit board with a first surface and a second surface opposite and parallel to each other. The lamp cap comprises a side wall, an end wall, and a slot with a first rib. There is a coupling structure protruded on the first rib with respect to the first surface of the second circuit board.

Abstract: An LED tube lamp, comprising: a lamp tube; a first circuit board, disposed in the lamp tube, having a plurality of light sources mounted thereon; two lamp caps disposed at respective ends of the lamp tube; a power supply substantially disposed in one or both of the two lamp caps, the power supply having a second circuit board; and a connection structure having a third circuit board, the third circuit board for connecting the first circuit board to the second circuit board thereby connecting the light sources to the power supply.

Abstract: An LED light bulb having a bulb base and a bulb shell connected with the bulb base, the bulb shell having a layer of luminescent material formed in the material of the bulb shell. A stem with a stand extending to the center of the bulb shell is disposed in the bulb shell. A flexible LED filament is disposed in the bulb shell, at least half of the LED filament is disposed around a center axle of the LED light bulb, where the center axle is coaxial with the axle of the stand and two conductive supports, each of which are connected with the stem and the LED filament. A driving circuit is electrically connected with the two conductive supports and the bulb base. Additionally, a plurality of supporting arms has two ends, with one end connected to the stem and the other end connected to the LED filament.

Abstract: Systems and methods for detecting image anomalies include extracting one or more detected images from a submission file received from at least one computing device and generating an image identification (ID) for each of the one or more images. One or more image quality indices are determined for the submission file based on at least one of predetermined image features, an image type of the one or more images, and submission file attributes, and one or more image anomalies associated with the one or more images of the submission file are detected based on at least one of the image ID and the one or more image quality indices.

Abstract: An LED tube lamp comprises a lamp tube, a first circuit board disposed in the lamp tube having a plurality of light sources mounted thereon, and two lamp caps respectively disposed at both ends of the lamp tube and having a power supply disposed in the lamp caps. The power supply has a second circuit board with a first surface and a second surface opposite and parallel to each other. The lamp cap comprises a side wall, an end wall, and a slot with a first rib. There is a coupling structure protruded on the first rib with respect to the first surface of the second circuit board.

Abstract: Systems and methods for detecting image anomalies include extracting one or more detected images from a submission file received from at least one computing device and generating an image identification (ID) for each of the one or more images. One or more image quality indices are determined for the submission file based on at least one of predetermined image features, an image type of the one or more images, and submission file attributes, and one or more image anomalies associated with the one or more images of the submission file are detected based on at least one of the image ID and the one or more image quality indices.

Abstract: Systems, methods, and computer-readable storage media are described for estimating real estate property values based on an adjusted repeat sales model using a regularized estimator. In one exemplary embodiment, a computer-implemented method calculates data for estimating the adjustments from an aggregated level to a first disaggregated level by marking a first transaction to a second transaction using a repeat sales house price index function at the aggregated level. The method also determines, using the calculated data, a regularized estimate of the deviation between the repeat sales house price index at the aggregated level and a repeat sales house price index at the first disaggregated level. The method further calculates the repeat sales house price index at the first disaggregated level based on the determined regularized estimate of the deviation from the aggregated level.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract: A light bulb, consisting of: a lamp housing doped with a golden yellow material or its surface coated with a yellow film; a bulb base connected to the lamp housing; a stem connected to the bulb base and located in the lamp housing, the stem comprises a stand extending to the center of the lamp housing; and a single LED filament, disposed in the lamp housing, the LED filament comprising: a plurality of LED sections, each of the LED sections includes at least two LED chips that are electrically connected to each other by a wire; a plurality of conductive sections, each of the conductive sections is located between the two adjacent LED sections and configured to electrically connect the two adjacent LED sections; a plurality of supporting arms, each of the supporting arms comprises a first end and a second end opposite to the first end of the supporting arms, the first end of each of the supporting arms is connected with the stand while the second end of each of the supporting arms is connected with the LED fila

Abstract: An LED light bulb, consisting of: a bulb shell, including a layer of luminescent material integrately formed in the material of the bulb shell; a bulb base, connected with the bulb shell; a stem with a stand extending to the center of the bulb shell, disposed in the bulb shell; a LED filament disposed in the bulb shell, at least a half of the LED filament is around a center axle of the LED light bulb, where the center axle of the LED light bulb is coaxial with the axle of the stand, and two conductive supports, each of the two conductive supports connected with the stem and the flexible LED filament; a driving circuit, electrically connected with both the two conductive supports and the bulb base; and a plurality of supporting arms respectively comprising two ends, an end of each of the supporting arm is connected to the stem and another end of each of the supporting arm is connected to the flexible LED filament.

Abstract: Methods, systems, and devices are disclosed for implementing magnetoencephalography (MEG) source imaging. In one aspect, a method includes determining a covariance matrix based on sensor signal data in the time domain or frequency domain, the sensor signal data representing magnetic-field signals emitted by a brain of a subject and detected by MEG sensors in a sensor array surrounding the brain, defining a source grid containing source locations within the brain that generate magnetic signals, the source locations having a particular resolution, in which a number of source locations is greater than a number of sensors in the sensor array, and generating a source value of signal power for each location in the source grid by fitting the selected sensor covariance matrix, in which the covariance matrix is time-independent based on time or frequency information of the sensor signal data.

Abstract: An LED filament light bulb, consisting of: a bulb shell doped with a golden yellow material or its surface coated with a yellow film; a bulb base connected to the bulb shell; a stem connected to the bulb base and located in the bulb shell, the stem comprises a stand extending to the center of the bulb shell; and a single filament, disposed in the light housing, further comprising a plurality of supporting arms, each of the supporting arms comprises a first end and a second end opposite to the first end of the supporting arms, the first end of each of the supporting arms is connected with the stand while the second end of each of the supporting arms is connected with the LED filament.

Abstract: An light bulb, comprising:a bulb shell, a bulb base connected to the bulb shell; a stem connected to the bulb base and located in the bulb shell; and a flexible LED filament, disposed in the bulb shell, further comprising a plurality of supporting arms respectively comprising two ends, an end of each of the supporting arm is connected to the stem and another end of each of the supporting arm is connected to the flexible LED filament, wherein the stem comprises a stand extending to the center of the bulb shell, the stand supports the supporting arms.

Abstract: An LED light bulb, comprising: a lamp housing, doped with a golden yellow material or coated with a yellow film on its surface, a bulb base, connected with the lamp housing, a stem with a stand extending to the center of the lamp housing, disposed in the lamp housing, LED filament disposed in the lamp housing, at least a half of the LED filament is around a center axle of the LED light bulb, where the center axle of the LED light bulb is coaxial with the axle of the stand. two conductive supports, connected with the stem and the LED filament, a driving circuit, electrically connected with both the conductive supports and the bulb base.

Abstract: An LED light bulb, comprising: a bulb shell with inner surface and outer surface opposite to the inner surface of the bulb shell, the bulb shell includes a layer of luminescent material which is formed on the inner surface or the outer surface of the bulb shell or integrated in the material of the bulb shell; a bulb base connected to the bulb shell; a stem connected to the bulb base and located in the bulb shell, the stem comprises a stand extending to the center of the bulb shell; and a single LED filament, disposed in the bulb shell, the LED filament comprising: a plurality of LED chip units, each of the LED chip units comprises at least two LED chips; a plurality of conductors respectivity located on opposite sides of the LED chip units; wherein a Cartesian coordinate system having an x-axis, a y-axis is oriented for the LED filament where the x-axis is parallel to the length direction of the LED filament, the conductors are parallel to the x direction and at least one of the plurality of conductors is ele

Abstract: Systems and methods for detecting image anomalies include extracting one or more detected images from a submission file received from at least one computing device and generating an image identification (ID) for each of the one or more images. One or more image quality indices are determined for the submission file based on at least one of predetermined image features, an image type of the one or more images, and submission file attributes, and one or more image anomalies associated with the one or more images of the submission file are detected based on at least one of the image ID and the one or more image quality indices.

Abstract: An light bulb comprise a lamp housing filled with gas which doped with a golden yellow material or coated with a yellow film on its surface; a bulb base, connected with the lamp housing; a stem with a stand extending to the center of the lamp housing, disposed in the lamp housing; a LED filament disposed in the lamp housing, at least a half of the LED filament is around a center axle of the LED light bulb, where the center axle of the LED light bulb is coaxial with the axle of the stand, two conductive supports, respectively connected with the stem and the LED filament; a driving circuit, electrically connected with both the conductive supports and the bulb base.

Abstract: An LED light bulb, consisting of: a lamp housing with inner surface and outer surface opposite to the inner surface of the lamp housing, the lamp housing includes a layer of luminescent material which is formed on the inner surface or the outer surface of the lamp housing or integrated in the material of the lamp housing; a bulb base connected to the lamp housing;a stem connected to the bulb base and located in the lamp housing, the stem comprises a stand extending to the center of the lamp housing; and a single filament, disposed in the light housing, a plurality of supporting arms, each of the supporting arms comprises a first end and a second end opposite to the first end of the supporting arms, the first end of each of the supporting arms is connected with the stand while the second end of each of the supporting arms is connected with LED filament.

Abstract: An LED light bulb, comprising:a lamp housing, doped with a golden yellow material or coated with a yellow film on its surface,a bulb base, connected with the lamp housing, a stem with a stand extending to the center of the lamp housing, disposed in the lamp housing, a LED filament disposed in the lamp housing, at least a half of the LED filament is around a center axle of the LED light bulb, where the center axle of the LED light bulb is coaxial with the axle of the stand, two conductive supports, connected with the stem and the LED filament.