Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract: Methods, systems, and devices are disclosed for implementing magnetoencephalography (MEG) source imaging. In one aspect, a method includes determining a covariance matrix based on sensor signal data in the time domain or frequency domain, the sensor signal data representing magnetic-field signals emitted by a brain of a subject and detected by MEG sensors in a sensor array surrounding the brain, defining a source grid containing source locations within the brain that generate magnetic signals, the source locations having a particular resolution, in which a number of source locations is greater than a number of sensors in the sensor array, and generating a source value of signal power for each location in the source grid by fitting the selected sensor covariance matrix, in which the covariance matrix is time-independent based on time or frequency information of the sensor signal data.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. In certain embodiments, also disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof.

Abstract: A system and method for determining matching pairs between social networks is disclosed. The system comprises a matching module that includes an account retrieval engine, candidate pairing module, a match determination module, a social network engine, a personalizing engine and a graphical user interface engine. The candidate pairing module generates candidate pairs of accounts from different social networks that may represent the same user. The match pairing module generates scores for the pairs. The match determination module determines a subset of the pairs that most likely represent the same users.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract: In one aspect, a processing device of an information processing system is operative to perform high-dimensional stratified sampling of a database comprising a plurality of records arranged in overlapping sub-groups. For a given record, the processing device determines which of the sub-groups the given record is associated with, and for each of the sub-groups associated with the given record, checks if a sampling rate of the sub-group is less than a specified sampling rate. If the sampling rate of each of the sub-groups is less than the specified sampling rate, the processing device samples the given record, and otherwise does not sample the given record. The determine, check and sample operations are repeated for additional records, and samples resulting from the sample operations are processed to generate information characterizing the database.

Abstract: A grammar for mapping a first grouping of XML data into a second grouping of XML data and a method for accomplishing same to incorporate the first grouping into the second grouping. The grammar includes a first rule for computing a first child element attribute and a second rule for computing a second parent element attribute. The first rule and second rule vary according to a production of an element type of the first grouping. The element types include PCDATA, disjunctive, conjunctive and Kleene star, each having a unique rule set for defining inherited and synthesized attributes of the parent and child elements. The method includes the step of executing a mapping of a first grouping having at least one parent element and a set of corresponding child elements into a second grouping in accordance with the grammar rules based on the production of the element type.

Abstract: Techniques, devices and systems are disclosed for magnetoencephalography (MEG) source imaging. In one aspect, a method includes selecting signal data associated with one or more frequency bands from a spectrum of the signal data in the frequency domain, in which the signal data represents magnetic signals emitted by a brain of a subject and detected by a plurality of sensors outside the brain, defining locations of sources within the brain that generate the magnetic signals, in which the number of locations of the sources is selected to be greater than the number of sensors, and generating a source value of signal power based on the selected signal data corresponding to a respective location of the locations at the one or more frequencies.

Abstract: A processing device of an information processing system is operative to obtain a plurality of records, documents, web pages or other data objects, and to construct a binary tree using a bipartition procedure in which subsets of the data objects are associated with respective nodes of the tree. Evaluation of a designated modularity for a given one of the nodes of the tree is used as a stopping criterion to prevent further partitioning of that node and to indicate designation of that node as a leaf node of the tree. The resulting leaf nodes of the tree provide a non-overlapping partitioning of the plurality of data objects. The processing device is further operative to perform a neighborhood search on the tree to identify pairs of the plurality of data objects that match the same entity, and to store an indication of the matching pairs of data objects.

Abstract: In one aspect, a processing device of an information processing system is operative to perform high-dimensional stratified sampling of a database comprising a plurality of records arranged in overlapping sub-groups. For a given record, the processing device determines which of the sub-groups the given record is associated with, and for each of the sub-groups associated with the given record, checks if a sampling rate of the sub-group is less than a specified sampling rate. If the sampling rate of each of the sub-groups is less than the specified sampling rate, the processing device samples the given record, and otherwise does not sample the given record. The determine, check and sample operations are repeated for additional records, and samples resulting from the sample operations are processed to generate information characterizing the database.

Abstract: In one aspect, a processing device of an information processing system is operative to perform high-dimensional stratified sampling of a database comprising a plurality of records arranged in overlapping sub-groups. For a given record, the processing device determines which of the sub-groups the given record is associated with, and for each of the sub-groups associated with the given record, checks if a sampling rate of the sub-group is less than a specified sampling rate. If the sampling rate of each of the sub-groups is less than the specified sampling rate, the processing device samples the given record, and otherwise does not sample the given record. The determine, check and sample operations are repeated for additional records, and samples resulting from the sample operations are processed to generate information characterizing the database.

Abstract: An optimized gateway selection process of the present invention is based on a universal mobility manager (UMM), a component for inter-technology location management. The UMM is capable of holding location information for diverse cellular networks, as well as for Internet telephony systems. For cellular networks, UMM acts as a traditional HLR; for an Internet telephony network, it acts as the entities that are responsible for user/terminal registration (registrar in SIP, gatekeeper in H.323) and address resolution (proxy server in SIP, gatekeeper in H.323). An optimal gateway selection is possible based on location related information provided by the UMM which had not previously been available. Utilizing the newly available information enables a gateway to be selected which may, for example, enable the circuit switched portion of a call to now be minimized.

Abstract: Techniques and systems are disclosed for implementing multi-core beamforming algorithms. In one aspect, a method of implementing a beamformer technique includes using a spatial filter that contains lead-fields of two simultaneous dipole sources rather than a linear combination of the two to directly compute and obtain optimal source orientations and weights between two highly-correlated sources.

Abstract: Systems, methods, and computer-readable storage media are described for estimating real estate property values based on an adjusted repeat sales model using a regularized estimator. In one exemplary embodiment, a computer-implemented method calculates data for estimating the adjustments from an aggregated level to a first disaggregated level by marking a first transaction to a second transaction using a repeat sales house price index function at the aggregated level. The method also determines, using the calculated data, a regularized estimate of the deviation between the repeat sales house price index at the aggregated level and a repeat sales house price index at the first disaggregated level. The method further calculates the repeat sales house price index at the first disaggregated level based on the determined regularized estimate of the deviation from the aggregated level.

Abstract: Methods and apparatus are provided for propagating functional dependencies with conditions. Propagation covers are computed using an SPC view of a dataset, wherein the SPC view comprises selection, projection and Cartesian product operations. Selection operations are processed to extract equivalence classes. Cartesian product operations are processed to obtain a renamed set of the plurality of conditional functional dependencies, that have attributes appearing in the SPC view. Domain constraints from the equivalence classes are applied to the renamed set to remove attributes not in the SPC view. Projection operations are processed using a reduction by resolution procedure to identify inferences that can be propagated to the SPC view from the conditional functional dependencies having attributes that do not appear in the SPC view. Domain constraints of the equivalence classes are converted to conditional functional dependencies; and a minimal cover of the SPC view is determined.

Abstract: In one aspect, a processing device of an information processing system is operative to perform high-dimensional stratified sampling of a database comprising a plurality of records arranged in overlapping sub-groups. For a given record, the processing device determines which of the sub-groups the given record is associated with, and for each of the sub-groups associated with the given record, checks if a sampling rate of the sub-group is less than a specified sampling rate. If the sampling rate of each of the sub-groups is less than the specified sampling rate, the processing device samples the given record, and otherwise does not sample the given record. The determine, check and sample operations are repeated for additional records, and samples resulting from the sample operations are processed to generate information characterizing the database.

Abstract: A processing device of an information processing system is operative to obtain a plurality of records, documents, web pages or other data objects, and to construct a binary tree using a bipartition procedure in which subsets of the data objects are associated with respective nodes of the tree. Evaluation of a designated modularity for a given one of the nodes of the tree is used as a stopping criterion to prevent further partitioning of that node and to indicate designation of that node as a leaf node of the tree. The resulting leaf nodes of the tree provide a non-overlapping partitioning of the plurality of data objects. The processing device is further operative to perform a neighborhood search on the tree to identify pairs of the plurality of data objects that match the same entity, and to store an indication of the matching pairs of data objects.

Abstract: Full-chip scan data can be advantageously used during design planning to minimize top-level scan wires and scan feedthroughs. The scan cells can be reordered using a modified cost function to promote connecting all scan cells in one plan group before crossing to a scan cell in another plan group. The modified cost function can take into account penalty parameters. The penalty parameters can include at least one of: membership in a plan group or a top-level physical hierarchy, size of a plan group, FLOATING/ORDERED scan element in scan data, location of endpoints of an ORDERED list, location of endpoints of a macro, and membership in a plan group containing a STOP point. Scan data, at the block-level and at the top-level, can be automatically updated to reflect the plan groups and optimized scan chains.