Abstract: Various implementations described herein refer to an integrated circuit having a first stage and a second stage. The first stage has a step-down converter coupled to an oscillator between a first voltage supply and a second voltage supply. The second stage is coupled to the first stage, and the second stage has a current bias generator coupled to a diode-connected transistor between the first voltage supply and the second voltage supply. The second stage provides an intermediate voltage to the first stage.

Abstract: A computed tomography (CT) imaging system and method, wherein the system includes an x-ray source that is operable to emit a beam of x-rays from a focal spot and move a spot position of the focal spot. The system also includes a detector assembly that is configured to detect the x-rays attenuated by the object. At least one processing unit is configured to execute programmed instructions stored in memory. The at least one processing unit is configured to direct the x-ray source to emit different beams of the x-rays at different energy levels and to receive data from the detector assembly that are representative of detection of the x-rays emitted at the different energy levels. The at least one processing unit is also configured to direct the x-ray source to move the focal spot such that the focal spot is at different spot positions while the different beams are emitted.

Abstract: A data synchronization method, system and apparatus are provided. The method includes receiving a request including data to be uploaded, from a client, and responding to the request after data is successfully obtained from the client, and storing the obtained data. For data whose size is less than a threshold value, a synchronization request is sent to a standby server to request the standby server to store the data. Otherwise a second type work log, including information indicating that data that has not been synchronized, is generated and stored. Data whose size is greater than or equal to the threshold value is not synchronized immediately, but is recorded in the work log. In some cases, data whose size is less than the threshold value, but fails to be synchronized, is recorded in the work log. Synchronization of this data may be subsequently completed according to the work log, so that the synchronization of this data can avoid affecting synchronization of other data.

Abstract: Various implementations described herein are directed to a device having a voltage regulator that uses a modulator to adjust an output voltage. The device may include a time-to-digital converter that measures a timing delay of a logic chain, compares the timing delay to a reference delay to determine a timing delay error, and provides the timing delay error to the modulator for adjusting the output voltage.

Abstract: Various implementations described herein refer to a method for providing an integrated circuit with a real-time clock source. The method may include generating a real-time clock signal for the integrated circuit with the real-time clock source. The method may include selectively adjusting clock frequency of the real-time clock signal to save power in the integrated circuit.

Abstract: A crystal for flow cytometry with dual laser beams is disclosed. The crystal is a birefringent crystal comprising a material composition including a quartz mineral having a face side including a face angle of ninety degrees plus or minus one tenth of a degree; a wedge side that is substantially perpendicular to the face side, wherein the wedge side includes a wedge angle of two degrees plus or minus one tenth of a degree; and a major side that is substantially perpendicular to the face side and the wedge side. The major side includes a thickness of one and one-half millimeter plus or minus one tenth of a millimeter. A polarized light beam entering the birefringent crystal at an incident angle is separated into an ordinary light beam and an extraordinary light beam.

Abstract: Novel siRNA and shRNA nanocapsules and delivery methods are disclosed herein. These siRNA and shRNA nanocapsules and delivery methods are highly robust and effective. This invention provides a platform for RNAi delivery with low toxicity and long intracellular half-life for practical therapeutic applications.

Abstract: A manual park release device includes a base portion. A handle portion is rotatably coupled to the base portion to move from a retracted position to an extended position. The handle portion during rotation toward the extended position exerts a pulling force to displace a tension cable connected to an automatic transmission of an automobile vehicle to change from a first park gear to a second neutral gear. A first locking feature releasably restricts rotational movement of the handle portion away from the retracted position. A second locking feature releasably restricts rotational movement of the handle portion away from the extended position.

Abstract: Various implementations described herein are directed to a device having a voltage regulator that uses a modulator to adjust an output voltage. The device may include a time-to-digital converter that measures a timing delay of a logic chain, compares the timing delay to a reference delay to determine a timing delay error, and provides the timing delay error to the modulator for adjusting the output voltage.

Abstract: A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a grating system including a dispersive element and a receiver assembly, wherein the dispersive element is positioned to receive the fluorescent light from the fiber assembly and to direct spectrally dispersed light toward the receiver assembly.

Abstract: A system, method, and apparatus are provided for cytometry with dual laser beams. In one example, the method includes directing an incident light beam from a source to enter an optical waveplate; polarizing the incident light beam into a polarized light beam in response to the incident light beam entering through the optical waveplate; directing the polarized light beam to enter a birefringent crystal; separating the polarized light beam into an ordinary light beam and an extraordinary light beam in response to the polarized light beam entering the birefringent crystal; directing the ordinary light beam and the extraordinary light beam to enter a lens; focusing the ordinary light beam and the extraordinary light beam into dual light beams separated by a beam displacement; and coupling the dual light beams to form a sample region having substantially uniform light intensity to analyze moving particles in the particle analyzer.

Abstract: Provided are a 3-epimerase, an encoding polynucleotide therefor, a nucleic acid construct, vector, and host cell comprising the polynucleotide, a method for producing the 3-epimerase, and use of the 3-epimerase.

Abstract: Various implementations described herein refer to an integrated circuit having a first stage and a second stage. The first stage has a step-down converter coupled to an oscillator between a first voltage supply and a second voltage supply. The second stage is coupled to the first stage, and the second stage has a current bias generator coupled to a diode-connected transistor between the first voltage supply and the second voltage supply. The second stage provides an intermediate voltage to the first stage.

Abstract: Embodiments of the present application provide a method, apparatus, electronic device for displaying an image and a storage medium. The method and apparatus are applied to an electronic device. The method comprises: determining a display angle of a 3D wallpaper containing elements, wherein the 3D wallpaper is obtained by pasting an overall spherical panoramic image containing all the elements onto one 3D model; determining a graphic to be displayed corresponding to the display angle in the overall spherical panoramic image; and rendering the graphic to be displayed and displaying the rendered graphic. In the embodiments, when the graphic to be displayed corresponding to the display angle of the 3D wallpaper is rendered, the operation on unnecessary occluded parts is avoided, thereby reducing the amount of computation in displaying the 3D wallpaper and saving the computing resources.

Abstract: A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a grating system including a dispersive element and a receiver assembly, wherein the dispersive element is positioned to receive the fluorescent light from the fiber assembly and to direct spectrally dispersed light toward the receiver assembly.

Abstract: A transistor device disposed on a substrate and including a semiconductor layer, a first gate, a second gate, and two source drain electrodes is provided. The semiconductor layer is disposed on the substrate and has a channel region, two lightly-doped regions, and two source drain regions. Each of the two lightly-doped regions has a first boundary adjoined to the channel region and a second boundary adjoined to one of the two source drain regions. The first gate is extended over the channel region of the semiconductor layer, wherein an edge of the first gate is aligned with the first boundary. The second gate is stacked on the first gate and is in contact with the first gate, wherein in a thickness direction, the second gate is overlapped with the two lightly-doped regions. The two source drain electrodes are respectively in contact with the two source drain regions.

Abstract: Novel siRNA and shRNA nanocapsules and delivery methods are disclosed herein. These siRNA and shRNA nanocapsules and delivery methods are highly robust and effective. This invention provides a platform for RNAi delivery with low toxicity and long intracellular half-life for practical therapeutic applications.

Abstract: A transistor device disposed on a substrate and including a semiconductor layer, a first gate, a second gate, and two source drain electrodes is provided. The semiconductor layer is disposed on the substrate and has a channel region, two lightly-doped regions, and two source drain regions. Each of the two lightly-doped regions has a first boundary adjoined to the channel region and a second boundary adjoined to one of the two source drain regions. The first gate is extended over the channel region of the semiconductor layer, wherein an edge of the first gate is aligned with the first boundary. The second gate is stacked on the first gate and is in contact with the first gate, wherein in a thickness direction, the second gate is overlapped with the two lightly-doped regions. The two source drain electrodes are respectively in contact with the two source drain regions.

Abstract: The disclosed methods are generally directed to preventing, treating, suppressing, controlling or otherwise mitigating side effects of T-cell therapy, the T-cell therapy designed to accelerate immune reconstitution, induce a GVM effect, and/or target tumor cells.

Abstract: A method for intracellular delivery of single proteins or other cargo molecules by encapsulation within nanocapsules formed by interfacial polymerization of one or more types of monomers and selected protease cleavable cross-linkers is provided. The thin positively charged capsules are readily brought into the cytosol of target cells by endocytosis. The capsules are degraded by the action of endogenous proteases or co-delivered proteases on the cross-linkers releasing the functional cargo unaltered. The cross-linkers can be adapted to be cleavable by specific enzymes selected from available intracellular enzymes within the target cell or co-delivered or self-cleaving when the cargo itself is a protease. The nanocapsules produced by the methods have been shown to have long-term stability, high cell penetration capability, low toxicity and efficient protease-modulated specific degradability without affecting cargo protein function.