Abstract: The present disclosure provides materials and methods related to image processing. In particular, the present disclosure provides methods for enhancing target signal detection using imaging processing analysis that identifies and removes non-specific background signals. The image processing methods of the present disclosure are useful for enhancing target signals in a variety of assays that involve fluorescent detection (e.g., fluorescent in situ hybridization, immunofluorescence).

Abstract: Teachings of the present disclosure include methods, apparatus, electronic devices, and medium for marking an operating parameter. An example method includes: acquiring a three-dimensional image sequence of a spindle motion process of a machine tool, the three-dimensional image sequence captured by an imaging component; creating an operating parameter curve representing the spindle motion process; recognizing a spindle motion mode from the three-dimensional image sequence; determining time information of the spindle motion mode; and marking the operating parameter curve based on the time information and motion description information associated with the spindle motion mode.

Abstract: Input devices can employ ultrasonic touch sensing capabilities that allow user inputs to be detected through conductive materials, such as metal enclosures. The ultrasonic touch sensing can include generation of ultrasound signals with a piezoelectric layer. The ultrasound signals can be reflected when a user or other object is in contact with a housing, and the reflected signal can be detected by the same piezoelectric layer that produced the ultrasound signal. Such a piezoelectric layer can include a piezoelectric polymer, such as polyvinylidene fluoride (PVDF). An array of electrodes distributed on opposing sides of the use of electric layer can be operated to generate ultrasound signals and detect reflected signals. Such an input device can be operated in conjunction with a conductive (e.g., metallic) housing, conform to a variety of shapes, and be compact and lightweight.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The present disclosure relates to a network resource request method. An example method includes obtaining network intent information of a user, where the network intent information includes quantity information of a terminal device and service requirement information of the terminal device. The example method further includes performing classification representation on the network intent information based on an intent model, where the intent model includes a terminal device set, a service flow set, and a mapping relationship between the terminal device set and the service flow set. The example method further includes generating service level agreement (SLA) information based on a representation result of the intent model and sending the SLA information to an element management system.

Abstract: The present disclosure relates to information processing methods and devices. In one example method, a first device obtains first information, where the first information indicates an intent, and the first device processes the intent based on second information, where the second information indicates an operation on the intent. In other words, after the first device determines the intent for the communication network, the first device processes the intent, based on the operation on the intent, to implement network operation and maintenance based on the intent.

Abstract: Methods and kits to distinguish normal or Barrett's esophageal samples from high grade dysplasia (HGD), esophageal adenocarcinoma (EAC), or junctional adenocarcinoma (JCA) samples are described. The methods and kits utilize the methylation status of epigenetic markers, such as cg6522, POU3F1, YPEL3, and/or MAFB.

Abstract: A method of imaging, the method comprising administering, to a subject, a compound of Structure Alpha, of the formula: or a pharmaceutically acceptable salt thereof, wherein: n is 0; R, R1, and R3 are independently selected from the group consisting of H, OR4, F, Cl, Br, I, CF3, alkyl (C1-C4), aryl, heteroaryl, C(?O)R4, CO2R4, N(R4)2, CN, C(?NR4)OR5, NR4C(?NR5)NHR6, C(?NR4)NHR5, C(?O)NHR4, NR4C(?O)NR5, NR4NR5, SO2OR4, and imaging moiety Im; R2 is absent; R4, R5, and R6 are independently selected from the group consisting of H, alkyl, aryl and heteroaryl substituents; wherein the alkyl, aryl, or heteroaryl may be substituted with imaging moiety Im, wherein optionally any two of R4, R5, and R6 form a cyclic structure selected from the group consisting of —CH2—CH2—, —CH2—CH2—CH2, —CH?CH—, —X?CH—, and —X—CH?CH—, wherein X is selected from the group consisting of O, NH, and NR7, and wherein R7 is selected from the group consisting of alkyl, aryl, and heteroaryl substituents; W, X, Y and Z are independently s

Abstract: The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

Abstract: Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.

Abstract: A method for detecting a processor comprises: determining a parameter stored in a first-type register in a detected processor, which is used to detect changes in the data processed by the detected processor, wherein the parameter relates to the a number of the data that needs to be processed currently by the detected processor, and relates to the a processing mode of the data that needs to be processed currently by the detected processor which can be characterized by using information of instructions or functions called during processing; determining a working state of the detected processor based on the parameter, and performing an interrupt missing handling operation if the working state is a first type of working state being an interrupt missing state. The method can conveniently and reliably realize the detection of interrupt loss, thereby effectively monitoring the situation of interrupt loss.

Abstract: A method and system for extracting a target signal based on maximum correlated kurtosis deconvolution are provided, which relate to a field of signal processing. The method includes: obtaining a microwave signal of a brain of a subject to be tested; filtering the microwave signal by using maximum correlated kurtosis deconvolution to obtain a filtered signal; performing mode decomposition on the filtered signal by using a complete ensemble empirical mode decomposition with adaptive noise to obtain a target response signal; and performing image reconstruction on the target response signal by using a delay sum beamforming to obtain a target bleeding image.

Abstract: Provided herein are compounds having an amide-based backbone that is connected to multiple ring structures, pharmaceutically acceptable salts of the compounds, pharmaceutical compositions thereof, and method of use thereof as selective allosteric inhibitors of EGFR mutants.

Abstract: A method for information processing, a device, and a computer readable storage medium are provided. The method includes the following. At an in-vehicle electronic device, in response to a determination that a received voice input is associated with switching a source device for switching a rendered content shown at the in-vehicle electronic device, voiceprint information of the voice input is obtained. A user identity corresponding to the voiceprint information is identified. A mapping table between user identities and connected electronic devices or connectable electronic devices is searched for a first electronic device corresponding to the identified user identity. In response to searching out the first electronic device, a first channel for transmission of rendered content between the in-vehicle electronic device and the first electronic device is established, so as to render a first presenting content which is received from the first electronic device through the first channel.

Abstract: Disclosed are a memory-partition-based device-startup method and apparatus, a computer readable storage medium, and an electronic device. The method includes: determining a boot status of an electronic device in a first boot mode at a preset occasion; reading, based on the boot status, first boot information from a first partition of a target memory; booting the electronic device in a second boot mode based on the first boot information, and acquiring system update information for the electronic device from a system update server; updating, based on the system update information, second boot information in a second partition of the target memory; and booting the electronic device in the first boot mode based on the updated second boot information.

Abstract: The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: This disclosure provides a culture media that facilitates survival and/or engraftment of transplanted cells. In one embodiment, this culture media comprises collagen I, albumin, L-glutamine and NaHCO3. In one embodiment, this culture media promotes enhanced survival and engraftment of ?-cells of human pancreatic islets transplanted under the skin. The protective effect of this culture media is mediated, at least partly, by upregulating anti-apoptotic signaling pathways.

Abstract: The invention provides compounds that modulate the activity of protein kinases that are associated with human diseases, disorders, and conditions. In particular, compounds of the invention inhibit LRRK2.

Abstract: The present disclosure provides materials and methods related to image processing. In particular, the present disclosure provides methods for enhancing target signal detection using imaging processing analysis that identifies and removes non-specific background signals. The image processing methods of the present disclosure are useful for enhancing target signals in a variety of assays that involve fluorescent detection (e.g., fluorescent in situ hybridization, immunofluorescence).