Patents by Inventor Motoo Yamasaki

Motoo Yamasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210008219
    Abstract: The invention provides a novel adrenomedullin derivative sustainable for a long period which is capable of substantially suppressing unwanted side effects while maintaining pharmacological effects of adrenomedullin. In an exemplary embodiment, the invention relates to a compound represented by formula (I): A-CH2-B (I) [wherein A is a modifying group comprising one or more polyethylene glycol groups, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is linked to the other moieties through a covalent bond of the nitrogen atom of the N-terminal ?-amino group of the peptide moiety B to the carbon atom of the methylene group] or a salt thereof, or a hydrate thereof.
    Type: Application
    Filed: September 29, 2020
    Publication date: January 14, 2021
    Applicant: University of Miyazaki
    Inventors: Kazuo Kitamura, Motoo Yamasaki
  • Patent number: 10842879
    Abstract: The invention provides a novel adrenomedullin derivative sustainable for a long period which is capable of substantially suppressing unwanted side effects while maintaining pharmacological effects of adrenomedullin. In an exemplary embodiment, the invention relates to a compound represented by formula (I): A-CH2—B (I) [wherein A is a modifying group comprising one or more polyethylene glycol groups, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is linked to the other moieties through a covalent bond of the nitrogen atom of the N-terminal ?-amino group of the peptide moiety B to the carbon atom of the methylene group] or a salt thereof, or a hydrate thereof.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: November 24, 2020
    Assignee: UNIVERSITY OF MIYAZAKI
    Inventors: Kazuo Kitamura, Motoo Yamasaki
  • Publication number: 20200198131
    Abstract: A clamp installation apparatus includes a robot arm pedestal having a rotary table; a robot arm installed on the rotary table of the robot arm pedestal and having a plurality of arms and a plurality of joints; a robot hand installed to a forefront arm of the plurality of arms; and a control device. The robot hand includes: a clamp holding section configured to hold the clamp; a fastening section configured to fasten an engaging section of the clamp to give a clamp force to a work; and a measuring section configured to collect position data of a predetermined member of the clamp. The clamp can be automatically installed and removed. Also, the heat curing can be carried out in the condition to have installed the clamp.
    Type: Application
    Filed: November 2, 2017
    Publication date: June 25, 2020
    Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Motoo TACHI, Yukiharu YAMASAKI
  • Publication number: 20200017593
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: July 22, 2019
    Publication date: January 16, 2020
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo HANAI, Kazuyasu NAKAMURA, Emi HOSAKA, Motoo YAMASAKI, Kazuhisa UCHIDA, Toyohide SHINKAWA, Susumu IMABEPPU, Yutaka KANDA, Naoko YAMANE, Hideharu ANAZAWA
  • Publication number: 20190360015
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: January 29, 2019
    Publication date: November 28, 2019
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Patent number: 10233247
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: March 19, 2019
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Patent number: 10233475
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: March 19, 2019
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Patent number: 10233246
    Abstract: The present invention relates to an antibody or antibody fragment comprising novel Cys residue, to which a hydrophilic macromolecular group or amphipathic macromolecular group can be bound at a high efficiency. In addition, the present invention relates to a monoclonal antibody modified product or an antibody fragment modified product in which cysteine residue is chemically modified.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: March 19, 2019
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Motoo Yamasaki, Yasuhisa Shiraishi
  • Publication number: 20180264123
    Abstract: The invention provides a novel adrenomedullin derivative sustainable for a long period which is capable of substantially suppressing unwanted side effects while maintaining pharmacological effects of adrenomedullin. In an exemplary embodiment, the invention relates to a compound represented by formula (I): A-CH2—B (I) [wherein A is a modifying group comprising one or more polyethylene glycol groups, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is linked to the other moieties through a covalent bond of the nitrogen atom of the N-terminal ?-amino group of the peptide moiety B to the carbon atom of the methylene group] or a salt thereof, or a hydrate thereof.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 20, 2018
    Applicant: University of Miyazaki
    Inventors: Kazuo Kitamura, Motoo Yamasaki
  • Publication number: 20170240647
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 16, 2017
    Publication date: August 24, 2017
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo HANAI, Kazuyasu NAKAMURA, Emi HOSAKA, Motoo YAMASAKI, Kazuhisa UCHIDA, Toyohide SHINKAWA, Susumu IMABEPPU, Yutaka KANDA, Naoko YAMANE, Hideharu ANAZAWA
  • Patent number: 9637545
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: May 2, 2017
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Publication number: 20160348145
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: July 5, 2016
    Publication date: December 1, 2016
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka KANDA, Mitsuo SATOH, Kazuyasu NAKAMURA, Kazuhisa UCHIDA, Toyohide SHINKAWA, Naoko YAMANE, Emi HOSAKA, Kazuya YAMANO, Motoo YAMASAKI, Nobuo HANAI
  • Patent number: 9409982
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependant cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: August 9, 2016
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Publication number: 20160039937
    Abstract: The present invention relates to an antibody or antibody fragment comprising novel Cys residue, to which a hydrophilic macromolecular group or amphipathic macromolecular group can be bound at a high efficiency. In addition, the present invention relates to a monoclonal antibody modified product or an antibody fragment modified product in which cysteine residue is chemically modified.
    Type: Application
    Filed: August 19, 2015
    Publication date: February 11, 2016
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Motoo YAMASAKI, Yasuhisa SHIRAISHI
  • Patent number: 9150639
    Abstract: The present invention relates to an antibody or antibody fragment comprising novel Cys residue, to which a hydrophilic macromolecular group or amphipathic macromolecular group can be bound at a high efficiency. In addition, the present invention relates to a monoclonal antibody modified product or an antibody fragment modified product in which cysteine residue is chemically modified.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: October 6, 2015
    Assignee: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Motoo Yamasaki, Yasuhisa Shiraishi
  • Publication number: 20150112046
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependant cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: October 22, 2014
    Publication date: April 23, 2015
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Yutaka KANDA, Mitsuo SATOH, Kazuyasu NAKAMURA, Kazuhisa UCHIDA, Toyohide SHINKAWA, Naoko YAMANE, Emi HOSAKA, Kazuya YAMANO, Motoo YAMASAKI, Nobuo HANAI
  • Patent number: 8895266
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: November 25, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Publication number: 20140234300
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 21, 2014
    Applicant: Kyowa Hakko Kirin Co., Ltd
    Inventors: Nobuo HANAI, Kazuyasu NAKAMURA, Emi HOSAKA, Motoo YAMASAKI, Kazuhisa UCHIDA, Toyohide SHINKAWA, Susumu IMABEPPU, Yutaka KANDA, Naoko YAMANE, Hideharu ANAZAWA
  • Patent number: 8679491
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: March 25, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Patent number: 8632996
    Abstract: A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: January 21, 2014
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Kenya Shitara, Nobuo Hanai, Emi Shoji, Mikiko Sakurada, Akiko Furuya, Kazuyasu Nakamura, Rinpei Niwa, Kenji Shibata, Motoo Yamasaki