Patents by Inventor Motoo Yamasaki

Motoo Yamasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycerol derivative
    Patent number: 7569706
    Abstract: (wherein R represents a residue comprising a reactive group or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: R1s each represent a hydrogen atom or a group capable of being transformed into a hydrogen atom, and 6 or more of R1s may be the same or different) The compound represented by the above formula (1), which is capable of modifying a physiologically active polypeptide or a derivative thereof, or a low molecular compound while maintaining the physiological activity, or which is useful for improving the stability or water-solubility of the low molecular compound, are provided.
    Type: Grant
    Filed: September 2, 2003
    Date of Patent: August 4, 2009
    Assignees: Kyowa Hakko Kirin Co., Ltd., Tecno Network Shikoku Co., Ltd.
    Inventors: Hisao Nemoto, Motoo Yamasaki, Toshiyuki Suzawa, Hiroyuki Yamaguchi
  • GLYCOENGINEERED, RECOMBINANT ANTIBODY
    Publication number: 20090191199
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: January 9, 2009
    Publication date: July 30, 2009
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Yutaka KANDA, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • GLYCOENGINEERED, RECOMBINANT ANTIBODY
    Publication number: 20090191592
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: January 9, 2009
    Publication date: July 30, 2009
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Yutaka KANDA, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Chemically modified polypeptides
    Patent number: 7547675
    Abstract: The present invention relates to a chemically modified polypeptide in which at least one of hydroxyl groups in the polypeptide molecule is modified with a polyalkylene glycol derivative; a method for producing the modified polypeptide; a method of treatment using the modified polypeptide; use of the modified polypeptide; a pharmaceutical preparation comprising the modified polypeptide; and a composition for treatment comprising the modified polypeptide.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: June 16, 2009
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Ken Kobayashi, Noboru Konishi, Shiro Akinaga, Kumiko Maruyama
  • Branched polyalkylene glycols
    Patent number: 7547765
    Abstract: The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity are bound; and a physiologically active polypeptide modified with the branched polyalkylene glycol.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: June 16, 2009
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Tatsuya Murakami, Noriko Sukurai, Kinya Yamashita, Mayumi Mukai, Takashi Kuwabara
  • Antibody Composition-Producing Cell
    Publication number: 20080261301
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: April 1, 2008
    Publication date: October 23, 2008
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody Composition-Producing Cell
    Publication number: 20080227196
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Application
    Filed: March 14, 2008
    Publication date: September 18, 2008
    Inventors: Yutaka Kanda, Mitsuo Satch, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Antibody composition-producing cell
    Patent number: 7425446
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: September 16, 2008
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20080177043
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 24, 2008
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Mammalian host cell modified by RNAi to inhibit ? 1,6-fucosyltransferase
    Patent number: 7393683
    Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: July 1, 2008
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
  • BRANCHED POLYALKYLENE GLYCOLS
    Publication number: 20080125350
    Abstract: The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity are bound; and a physiologically active polypeptide modified with the branched polyalkylene glycol.
    Type: Application
    Filed: October 23, 2007
    Publication date: May 29, 2008
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Tatsuya Murakami, Noriko Sukurai, Kinya Yamashita, Mayumi Mukai, Takashi Kuwabara
  • Branched polyalkylene glycols
    Patent number: 7291713
    Abstract: The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group convertible into the group having reactivity are bound; and a physiologically active polypeptide modified with the branched polyalkylene glycol.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: November 6, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Motoo Yamasaki, Toshiyuki Suzawa, Tatsuya Murakami, Noriko Sakurai, Kinya Yamashita, Mayumi Mukai, Takashi Kuwabara
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070207151
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: September 6, 2007
    Applicant: KYOWA HAKKO KOGYO CO. LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166304
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166303
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166305
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166302
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the liker an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166301
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Method of Modulating the Activity of Functional Immune Molecules
    Publication number: 20070166300
    Abstract: The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Applicant: KYOWA HAKKO KOGYO CO., LTD.
    Inventors: Nobuo Hanai, Kazuyasu Nakamura, Emi Hosaka, Motoo Yamasaki, Kazuhisa Uchida, Toyohide Shinkawa, Susumu Imabeppu, Yutaka Kanda, Naoko Yamane, Hideharu Anazawa
  • Anti-fibroblast growth factor-8 monoclonal antibody
    Patent number: 7241568
    Abstract: A method for preventing or treating a disease, comprising administering to human or animal in need of such prevention or treatment an effective amount of a monoclonal antibody which specifically binds to FGF-8 and inhibits FGF-8 activity.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: July 10, 2007
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Nobuo Hanai, Motoo Yamasaki, Akiko Furuya, Akira Tanaka, Kenya Shitara, Naoki Shimada, Kazuyasu Nakamura, Maiko Hirota