Patents by Inventor Motoo Yamasaki
Motoo Yamasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6245900Abstract: The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity is chemically modified by a chemical modifying agent, and a platelet production promoter comprising said polypeptide, a method for treating a patient with decreased platelet counts comprising administering an effective amount of said polypeptide to the patient, the use of said polypeptide for the production of pharmaceutical compositions which are useful for the treatment of the patient with decreased platelet counts, and the compositions for treating the patient with decreased platelet counts, which comprises an effective dose of said polypeptide in a pharmaceutically acceptable dosage form with a pharmaceutical acceptable carrier.Type: GrantFiled: August 16, 1996Date of Patent: June 12, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Motoo Yamasaki, Masami Okabe, Toshiyuki Suzawa, Ken Kobayashi, Kumiko Maruyama
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Patent number: 6194195Abstract: The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.Type: GrantFiled: October 27, 1998Date of Patent: February 27, 2001Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
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Patent number: 6103236Abstract: The present invention relates to a toxin conjugate in which a residue derived from a compound having an affinity for a target cell is bound to a toxin through a spacer comprising polyalkylene glycol and dipeptide.Type: GrantFiled: November 10, 1997Date of Patent: August 15, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiyuki Suzawa, Motoo Yamasaki, Satoru Nagamura, Hiromitsu Saito, So Ohta, Nobuo Hanai
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Patent number: 6027720Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: July 13, 1994Date of Patent: February 22, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5994518Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: July 9, 1997Date of Patent: November 30, 1999Assignee: Kyowa Hakko Co., LtdInventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5977298Abstract: The present invention relates to compounds represented by formula (I): ##STR1## wherein Z represents Gly or Cys; X represents an (.alpha.-amino acid residue; Y represents a natural calcitonin moiety, a partial natural calcitonin peptide moiety, or a natural calcitonin-like peptide moiety; m represents an integer of 5-8, .alpha.-amino acid residues represented by X being the same or different; and n represents an integer of 0-3; provided that when m is 5, the sequence of 4 C-terminal residues of --(X).sub.m -- is different from the sequence of the third to sixth amino acids of natural calcitonin, and pharmaceutically acceptable salts thereof.Type: GrantFiled: September 22, 1997Date of Patent: November 2, 1999Assignee: Kvowa Hakko Kogyo Co., Ltd.Inventors: Kenji Shibata, Motoo Yamasaki, Masako Hamada, Tatsuya Tamaoki, Nobuo Kosaka, Soichiro Sato
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Patent number: 5952472Abstract: Described is a monoclonal antibody capable of specifically binding to fibroblast growth factor-8 (FGF-8) which is related to growth factors of hormone-dependent tumor cells such as prostatic cancer and breast cancer, and inhibits the FGF-8 activity. The monoclonal antibody is useful in analyzing the role and biological function of FGF-8 in hormone-dependent tumor cells such as prostatic cancer and breast cancer and can be beneficial in the treatment of these cancers.Type: GrantFiled: April 3, 1997Date of Patent: September 14, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Nobuo Hanai, Motoo Yamasaki, Akiko Furuya, Akira Tanaka
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Patent number: 5939280Abstract: An immunological assay for quantifying PEG-modified human granulocyte colony stimulating factor or derivatives thereof in a sample comprising bringing into contact with said sample an antibody which reacts with the human granulocyte colony stimulating factor or its derivative and with PEG-modified human granulocyte colony stimulating factor or its derivative and a monoclonal antibody which reacts specifically with the human granulocyte colony stimulating factor or its derivative but not with the PEG-modified human granulocyte-colony stimulating factor or its derivative.Type: GrantFiled: December 12, 1995Date of Patent: August 17, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Nobuo Hanai, Akiko Furuya, Motoo Yamasaki, Satoshi Kobayashi, Takashi Kuwabara
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Patent number: 5885830Abstract: An anti-ribonucleotide reductase (RNR) R2 subunit monoclonal antibody KM1054, KM1056 or KM1060, which belongs to the IgG2a subclass, reacts with R2 subunit of RNR, and inhibits RNR activity, is disclosed. It is effective for immunologically detecting RNR and for immunologically detecting the presence of human cancer cells.Type: GrantFiled: February 7, 1996Date of Patent: March 23, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiaki Saeki, Toshiaki Kamei, Akiko Furuya, Nobuo Hanai, Takeshi Takahashi, Masami Okabe, Motoo Yamasaki
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Patent number: 5858975Abstract: An oxyntomodulin peptide has cardiotonic activity and insulin release-promoting activity. The peptide or pharmaceutical salts thereof can be used for prevention or treatment of cardiopathy or diabetes.Type: GrantFiled: May 2, 1997Date of Patent: January 12, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Keiichi Yano, Motoo Yamasaki, Takahiro Moriyama, Masaaki Ando
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Patent number: 5846810Abstract: Provided are P112 protein and P31 protein which proteins are among proteins constituting human 26S proteasome, DNAs encoding the proteins, vectors into which the DNAs are inserted and cells carrying the vectors.The proteins of the present invention are useful not only for elucidating the function of the human 26S proteasome but also for the diagnosis or therapy of various diseases.Type: GrantFiled: July 24, 1995Date of Patent: December 8, 1998Assignee: Kyowa Hakko Kogyo Co. Ltd.Inventors: Keiichi Yano, Motoo Yamasaki, Keiji Tanaka
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Patent number: 5847074Abstract: The present invention relates to phopholipase C-inhibiting peptides which are represented by formula (I): ##STR1## wherein J.sup.1 and J.sup.2 are each hydrogen or combined together to form a single bond; W is hydrogen, a substituted or unsubstituted alkanoyl, a substituted or unsubstituted aroyl or coumaryl; X is a single bond, -Leu- or -Ser-Leu-Val-Glu-Leu-Val-Ser-Tyr-Tyr-Glu-Lys-His-Ala-Leu- (at least one of the N-terminal 14 amino acid residues may be deleted); Y is a single bond or -Pro-Val-; and Z is hydroxy or amino.Type: GrantFiled: May 5, 1995Date of Patent: December 8, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Motoo Yamasaki, Genkichi Ishikawa, Yoshimi Honma
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Patent number: 5795968Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: January 10, 1997Date of Patent: August 18, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5714581Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: May 3, 1995Date of Patent: February 3, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5681720Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: May 3, 1995Date of Patent: October 28, 1997Assignee: Kyowa Hakko Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5677420Abstract: The present invention relates to phospholipase C-inhibiting peptides which are represented by formula (I): ##STR1## wherein n represents 0 or 1; each J.sup.1 and J.sup.2 is a hydrogen atom, or J.sup.1 and J.sup.2 are combined together to form a single bond; W represents a hydrogen atom, a substituted or unsubstituted alkanoyl group, a substituted or unsubstituted aroyl group or coumaryl group; X represents a single bond, -Leu-, or -Ser-Leu-Val-Glu-Leu-Val-Ser-Tyr-Tyr-Glu-Lys-His-Ala-Leu- (wherein at least one amino acid residue may be deleted, inserted or substituted); Y represents a single bond or -Pro-Val-; R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; and R.sup.2 represents a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group.Type: GrantFiled: November 8, 1996Date of Patent: October 14, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Motoo Yamasaki, Genkichi Ishikawa, Yoshimi Honma
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Patent number: 5639860Abstract: Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.Type: GrantFiled: October 12, 1994Date of Patent: June 17, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Takeo Tanaka, Yoshikazu Morishita, Mika Makino, Shigeru Chiba, Isao Kawamoto, Eiji Tsukuda, Mayumi Yoshida, Chieko Bando, Kazuo Yamaguchi, Yuzuru Matsuda, Shigeto Kitamura, Toshihide Ikemura, Tatsuhiro Ogawa, Keiichi Yano, Toshiyuki Suzawa, Kenji Shibata, Motoo Yamasaki
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Patent number: 5631222Abstract: Disclosed is a peptide compound represented by the following formula (I):R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 -R.sup.6 -R.sup.7 -R.sup.8 -R.sup.9 -R.sup.10 -R.sup.11 -R.sup.12 -Phe-R.sup.14 -R.sup.15 -R.sup.16 -R.sup.17 -R.sup.18 -Ile-R.sup.20 -Z SEQ. ID NO. 64, (I)wherein R.sup.1-12, R.sup.14-18, and R.sup.20 are as defined in the specification.Type: GrantFiled: February 10, 1995Date of Patent: May 20, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kenji Shibata, Toshiyuki Suzawa, Motoo Yamasaki, Takeo Tanaka, Eiji Tsukuda, Koji Yamada, Tetsuji Ohno
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Patent number: 5580956Abstract: The present invention relates to a peptide which has phospholipase C-inhibiting activity and which has the amino acid sequence defined in Sequence Listing by SEQ ID: No. 1; or a modified peptide in which one or more of the amino acid residues of the above mentioned peptide are deleted, or in which one or more amino acid residues are added to the above mentioned peptide, and/or in which one or more of the amino acid residues are substituted with other amino acid residues or modified amino acid residues.Type: GrantFiled: November 10, 1993Date of Patent: December 3, 1996Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiromitsu Saito, Genkichi Ishikawa, Motoo Yamasaki, Yoshimi Honma
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Patent number: 5362853Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: December 22, 1992Date of Patent: November 8, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Yoshinori Komatsu