Patents by Inventor Murielle Rinaldi-Carmona

Murielle Rinaldi-Carmona has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrole derivatives, their preparation and their therapeutic application
    Patent number: 8680102
    Abstract: The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: March 25, 2014
    Assignee: Sanofi
    Inventors: Francis Barth, Daniel Bichon, Murielle Rinaldi-Carmona, Christian Congy
  • Derivatives of 3-alkoxy-4,5-diarylthiophene-2-carboxamide, preparation thereof, and therapeutic use thereof
    Patent number: 8486971
    Abstract: The invention relates to compounds of the formula (I), where: R1 is: a —NR5R6 group; an unsubstituted or substituted phenyl; R2 is: a (C1-C4)alkyl; an —X—R7 group; R3 and R4 each are independently a substituted phenyl; R5 is a hydrogen atom or a (C1-C4)alkyl; R6 is an unsubstituted or substituted (C1-C4)alkyl; or R5 and R6 together with the nitrogen atom to which they are bonded constitute an unsubstituted or substituted heterocyclic compound; X is a (C1-C5)alkylene; R7 is an —OR8 group, a —NR9R10 group, an —SO2—(C1-C4)alkyl group; R8 is a hydrogen atom or a (C1-C4)alkyl; R9 is a hydrogen atom or a (C1-C4)alkyl; R10 is a hydrogen atom, a —COR11 group, an —SO2R11 group or a —CO(CH2)mOH group; R11 is an unsubstituted or substituted (C1-C4)alkyl; m is 1, 2 or 3. The invention also relates to methods for preparing same and to the therapeutic use thereof.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: July 16, 2013
    Assignee: Sanofi
    Inventors: Jean-Philippe Ducoux, Murielle Rinaldi-Carmona, Arnaud Rouquette
  • Substituted 1-alkylcinnolin-4(1)-one derivatives, preparation thereof and therapeutic application of same
    Patent number: 8420651
    Abstract: The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C2-C5)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; R1 represents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; R2 represents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from —S-Alk, —SO-Alk, —SO2-Alk, —CO—N(R4)-Alk, —N(R4)SO2-Alk, —N(R4)CO-Alk, —N(R4)SO2—N(Alk)2; R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; R4 represents a hydrogen atom or a (C1-C4)alkyl; Alk represents an unsubstituted or substituted (C1-C4)alkyl. Preparation process and therapeutic application.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: April 16, 2013
    Assignee: Sanofi
    Inventors: Elodie Barbagallo, Carole Legeay, Murielle Rinaldi-Carmona, Pascale Roux, Claude Vernhet
  • Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8410137
    Abstract: The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n?—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: April 2, 2013
    Assignee: Sanofi
    Inventors: Francis Barth, Jean-Philippe Ducoux, Patrick Gueule, Murielle Rinaldi-Carmona, Arnaud Rouquette
  • Substituted 1-benzyl-cinnolin-4(1)-one derivatives, preparation thereof, and therapeutic use thereof
    Patent number: 8410099
    Abstract: The present invention is related to novel substituted 1-benzylcinnolin-4(1H)-one derivatives having affinity for cannabinoid CB2 receptors, their preparation and their therapeutic application.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: April 2, 2013
    Assignee: Sanofi
    Inventors: Claude Vernhet, Elodie Barbagallo, Murielle Rinaldi-Carmona, Pascale Roux
  • Pyrrole derivatives, preparation of same and therapeutic application thereof
    Patent number: 8383666
    Abstract: The subject of the invention is Compound of Formula (I): in which R1-R8 and R10 are defined within, its method of preparation, and its therapeutic application.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: February 26, 2013
    Assignee: Sanofi
    Inventors: Francis Barth, Audrey Jeanjean, Murielle Rinaldi-Carmona, Christian Congy
  • 5,6-diaryl pyridines substituted in the 2- and 3-position, preparation thereof and therapeutic use thereof
    Patent number: 8362045
    Abstract: The invention relates to compounds corresponding to formula (I): In which Ar1, Ar2, Q, Y, Z, Alk?, k and m are as defined herein. The invention further relates to their preparations, intermediates therefor and their therapeutic uses.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: January 29, 2013
    Assignee: Sanofi
    Inventors: Lionel Barre, Christian Congy, Philippe Pointeau, Murielle Rinaldi-Carmona
  • SUBSTITUTED 1-ALKYLCINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION OF SAME
    Publication number: 20120129864
    Abstract: The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C2-C5)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; R1 represents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; R2 represents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from —S-Alk, —SO-Alk, —SO2-Alk, —CO—N(R4)-Alk, —N(R4)SO2-Alk, —N(R4)CO-Alk, —N(R4)SO2—N(Alk)2; R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; R4 represents a hydrogen atom or a (C1-C4)alkyl; Alk represents an unsubstituted or substituted (C1-C4)alkyl. Preparation process and therapeutic application.
    Type: Application
    Filed: April 6, 2010
    Publication date: May 24, 2012
    Applicant: SANOFI
    Inventors: Elodie Barbagallo, Carole Legeay, Murielle Rinaldi-Carmona, Pascale Roux, Claude Vernhet
  • DERIVATIVES OF 3-ALKOXY-4,5-DIARYLTHIOPHENE-2-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
    Publication number: 20120115906
    Abstract: The invention relates to compounds of the formula (I), where: R1 is: a —NR5R6 group; an unsubstituted or substituted phenyl; R2 is: a (C1-C4)alkyl; an —X—R7 group; R3 and R4 each are independently a substituted phenyl; R5 is a hydrogen atom or a (C1-C4)alkyl; R6 is an unsubstituted or substituted (C1-C4)alkyl; or R5 and R6 together with the nitrogen atom to which they are bonded constitute an unsubstituted or substituted heterocyclic compound; X is a (C1-C5)alkylene; R7 is an —OR8 group, a —NR9R10 group, an —SO2—(C1-C4)alkyl group; R8 is a hydrogen atom or a (C1-C4)alkyl; R9 is a hydrogen atom or a (C1-C4)alkyl; R10 is a hydrogen atom, a —COR11 group, an —SO2R11 group or a —CO(CH2)mOH group; R11 is an unsubstituted or substituted (C1-C4)alkyl; m is 1, 2 or 3. The invention also relates to methods for preparing same and to the therapeutic use thereof.
    Type: Application
    Filed: March 25, 2010
    Publication date: May 10, 2012
    Applicant: SANOFI
    Inventors: Jean-Philippe Ducoux, Murielle Rinaldi-Carmona, Arnaud Rouquette
  • Substituted N-(4-cyano-1-pyrazol-3-yl)methylamine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8088797
    Abstract: The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: January 3, 2012
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona, Martine Vernhet
  • Pyrrole derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8044072
    Abstract: The invention relates to compounds having the formula (I): Wherein R1, R2, R3, R4, R5, R6, R7 and R8 and A-R9 are as defined herein. Also disclosed are the preparative methods for the compounds of formula (I) and their use in therapy.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: October 25, 2011
    Assignee: Sanofi Aventis
    Inventors: Francis Barth, Christian Congy, Laurent Hortala, Murielle Rinaldi-Carmona
  • THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20110183960
    Abstract: The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n?—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).
    Type: Application
    Filed: July 30, 2009
    Publication date: July 28, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Francis Barth, Jean-Philippe Ducoux, Patrick Gueule, Murielle Rinaldi-carmona, Arnaud Rouquette
  • PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
    Publication number: 20110152320
    Abstract: The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
    Type: Application
    Filed: November 9, 2010
    Publication date: June 23, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Francis Barth, Daniel Bichon, Murielle Rinaldi-Carmona, Christian Congy
  • PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF
    Publication number: 20110144157
    Abstract: The subject of the invention is Compound of Formula (I): in which R1-R8 and R10 are defined within, its method of preparation, and its therapeutic application.
    Type: Application
    Filed: November 9, 2010
    Publication date: June 16, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Audrey JEANJEAN, Murielle RINALDI-CARMONA, Christian CONGY
  • SUBSTITUTED 1-BENZYL-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
    Publication number: 20110144115
    Abstract: The present invention is related to novel substituted 1-benzylcinnolin-4(1H)-one derivatives having affinity for cannabinoid CB2 receptors, their preparation and their therapeutic application.
    Type: Application
    Filed: January 10, 2011
    Publication date: June 16, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Claude Vernhet, Elodie Barbagallo, Murielle Rinaldi-Carmona, Pascale Roux
  • Substituted 2,5-dihydro-3H-pyrazolo[4,3-C]pyridazin-3-one derivatives, preparation thereof and therapeutic use of the same
    Patent number: 7915258
    Abstract: The invention relates to compounds having the formula (I): Wherein R1, R2, R3 and R4 are as described herein. Also disclosed are the method of preparation and their use in therapy.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: March 29, 2011
    Assignee: Sanofi-Aventis
    Inventors: Christian Congy, Victor Dos Santos, Murielle Rinaldi-Carmona, Arnaud Rouquette, Didier Van Broeck
  • Pyrrole derivatives, intermediates therefor, preparation and therapeutic use thereof
    Patent number: 7879902
    Abstract: The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds including the intermediates therefor and their therapeutic use.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: February 1, 2011
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Laurent Hortala, Murielle Rinaldi-Carmona
  • Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics
    Patent number: 7875646
    Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: January 25, 2011
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
  • 5,6-DIARYL PYRIDINES SUBSTITUTED IN THE 2- AND 3-POSITION, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20100256202
    Abstract: The invention relates to compounds corresponding to formula (I): In which Ar1, Ar2, Q, Y, Z, Alk?, k and m are as defined herein. The invention further relates to their preparations, intermediates therefor and their therapeutic uses.
    Type: Application
    Filed: April 7, 2010
    Publication date: October 7, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Lionel BARRE, Christian CONGY, Philippe POINTEAU, Murielle RINALDI-CARMONA
  • Diaryl triazolmethylamine derivatives, preparation and therapeutic use thereof
    Patent number: 7781471
    Abstract: The invention concerns compounds of formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also concerns a method for preparing same and the therapeutic use thereof.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: August 24, 2010
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Murielle Rinaldi-Carmona