Abstract: The present invention is generally directed to accommodative intraocular lenses (IOLs) that exhibit a dynamic spherical aberration as a function of accommodative power. By way of example, in one aspect, the present invention provides an intraocular lens (IOL) having an anterior optical element, a posterior optical element, and a mechanism for coupling the anterior and posterior elements so as to allow axial movement of those elements relative to one another for providing accommodation when the lens is implanted in a patient's eye. Each of the anterior and the posterior elements includes at least one aspherical surface, where the asphericities of the surfaces are adapted to provide a combined spherical aberration that varies with accommodation.

Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: The present invention generally provides multifocal ophthalmic lenses, e.g., multifocal intraocular lenses, that employ a central refractive region for providing a refractive focusing power and a diffractive region for providing two diffractive focusing powers. In many cases, the refractive focusing power provided by the lens's central region corresponds to a far-focusing power that is substantially equal to one of the diffractive focusing powers while the other diffractive power corresponds to a near-focusing power. As such, in many cases, the focusing properties of the lenses are dominated by the far-focus ability, especially for small pupil sizes.

Abstract: Coated medical implants have an implant body configured for securing in or adjacent to body tissue of a patient. The implant body has an implant surface and a coating is formed on at least a portion of the implant surface. The coating includes a coating outer surface of a first chemical component that is chemically bonded to a carboxylate functionality of a second chemical component. The second chemical component is immobilized by amide linkage to an underlying third chemical component that is plasma coated directly onto implant body surfaces. The coating either inhibits or prevents the adhesion of protein and/or cellular proliferation or may be a non-fouling coating.

Abstract: In one aspect, the present invention provides an intraocular lens that includes a posterior optic and anterior optic. The optics have different chromatic dispersions adapted to cooperatively provide compensation for natural chromatic aberrations of the eye over a wavelength range of interest, e.g., over a wavelength range of about 400 nm to about 700 nm.

Abstract: Disclosed are ophthalmic device materials having improved light transmission characteristics. The materials contain a combination of certain UV absorbers and blue-light absorbing chromophores.

Abstract: In one aspect, the present invention provide an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior optical surface and a posterior optical surface, where the optic provides an optical power in a range of about 16 D to about 25 D as measured in a medium having an index of refraction substantially similar to that of the eye's aqueous humor (e.g., about 1.336). At least one of the optical surfaces is characterized by an aspherical base profile such that the optic exhibits a negative spherical aberration in a range of about ?0.202 microns to about ?0.190 microns across the power range.

Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain an aryl acrylic hydrophobic monomer as the single principal device-forming monomer and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: In one aspect, the present invention provides a method of designing an ocular implant (e.g., an IOL), which comprises establishing corneal topography of a patient's eye, e.g., by performing one or more wavefront aberration measurements of the eye, prior to an ocular surgery. The method further includes ascertaining an astigmatic aberration of the cornea that is expected to be induced by the surgery and determining a toricity of a surface of an ocular implant, which is intended for implantation in the patient's eye, so as to enable the implant to compensate for the surgically-induced aberration.

Abstract: The present invention is generally directed to multi-surface and/or multi-element intraocular lenses (IOLs) in which a plurality of surfaces are adapted to provide compensation for a variety of aberrations, and in particular, for off-axis aberrations such as coma or spherical aberration. In one aspect, an intraocular lens is disclosed that includes a posterior optic and an anterior optic. One optic provides compensation for a radially symmetric aberration and the other provides compensation for a radially asymmetric aberration.

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract: In one aspect, the present invention provides a method of designing a diffractive ophthalmic lens (e.g., an intraocular lens (IOL)) that includes providing an optic having an anterior refractive surface and a posterior refractive surface, wherein the optic provides a far-focus power (e.g., in a range of about 18 to about 26 Diopters (D)). A truncated diffractive structure can be disposed on at least one of the surfaces for generating a near-focus add power (e.g., in a range of about 3 D to about 4 D). And the diffractive structure can be adjusted so as to obtain a desired distribution of optical energy between the near and far foci for a range of pupil sizes.

Abstract: Disclosed are soft, high refractive index device materials having improved strength. The materials contain a monofunctional or difunctional, acrylate or methacrylate terminated aromatic functional methacrylic or acrylic macromer.

Abstract: In one aspect, the present invention provide an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior optical surface and a posterior optical surface, where the optic provides an optical power in a range of about 16 D to about 25 D as measured in a medium having an index of refraction substantially similar to that of the eye's aqueous humor (e.g., about 1.336). At least one of the optical surfaces is characterized by an aspherical base profile such that the optic exhibits a negative spherical aberration in a range of about ?0.202 microns to about ?0.190 microns across the power range.

Abstract: The present invention provides an ophthalmic lens (e.g., an intraocular lens) having an optic with an anterior surface and a posterior surface, which exhibits a shape factor (defined as a ratio of the sum of the anterior and posterior curvatures to the difference of such curvatures) in a range of about ?0.5 to about 4. In a related aspect, the shape factor of the optic lies in a range of about 0 to about 2. The above shape factors give rise to a plurality of different lens shapes, such as concave-convex, plano-convex and plano-concave.

Abstract: Disclosed are carrageenan-based transitional viscoelastics that will induce little or no IOP spike when left in the eye at the close of surgery thereon. Drug delivery systems for delivering therapeutic agents during post-operative recovery stages are also disclosed.

Abstract: Contour-matching, aspheric lenticules are disclosed for implantation in a subject's cornea to correcting refractive errors. The lenticules include a photoablatable anterior surface and a posterior surface having an aspheric profile that can substantially match the asphericity exhibited by the corneal stromal surface, on which the lenticule is placed. The posterior surface can have a generally concave shape while the anterior surface can have a generally convex shape, though other shapes can also be utilized in some embodiments. In some embodiments, the asphericity of the lenticule's posterior surface can differ from an asphericity exhibited by the corneal stromal surface by less than about 50%, or preferably by less than about 20%.

Abstract: Non-aspirating viscoelastics, compositions, and methods of use are disclosed. The non-aspirating, transitional viscoelastics possess sufficient viscosity to be useful in ophthalmic viscosurgery, but may be left in the eye with little or no resulting IOP spike. The compositions are particularly useful in cataract surgery.