Patents by Inventor Naoki Ishibashi
Naoki Ishibashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090281142Abstract: [Problem] To provide a compound which is useful as a GK activator. [Means for Resolution] As a result of an extensive study on thiazole derivatives, the present inventors have found that a compound having an oxamoyl group, a glycol group or the like on a thiazole ring and a compound having an acetamide group substituted by a bicyclic heteroaryl group such as a quinolyl have a good GK activation effect, and thereby have accomplished the present invention. Since the compounds of the present invention have a good GK activation effect, these are useful as therapeutic agents for diabetes, particularly type II diabetes.Type: ApplicationFiled: August 30, 2006Publication date: November 12, 2009Applicant: ASTELLAS PHARMA INC.Inventors: Masahiko Hayakawa, Takahiro Nigawara, Kazuyuki Tsuchiya, Naoki Ishibashi, Mitsuaki Okumura, Yuichiro Kawamoto, Akira Nagayoshi
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Patent number: 7557127Abstract: Compounds having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is pyrrolidinylene or piperidinylene, Y is pyridylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, and salts thereof are useful as a histone deacetylase inhibitors.Type: GrantFiled: November 4, 2008Date of Patent: July 7, 2009Assignee: Astellas Pharma Inc.Inventors: Naoki Ishibashi, Yuki Sawada, Yasuharu Urano, Shigeki Satoh, Yoshikazu Inoue, Yoshiteru Eikyu, Koichiro Mukoyoshi, Kazunori Kamijo, Fumiyuki Shirai, Hisashi Takasugi
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Publication number: 20090054464Abstract: Compounds having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is pyrrolidinylene or piperidinylene, Y is pyridylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, and salts thereof are useful as a histone deacetylase inhibitors.Type: ApplicationFiled: November 4, 2008Publication date: February 26, 2009Applicant: Astellas Pharma Inc.Inventors: Naoki ISHIBASHI, Yuki SAWADA, Yasuharu URANO, Shigeki SATOH, Yoshikazu INOUE, Yoshiteru EIKYU, Koichiro MUKOYOSHI, Kazunori KAMIJO, Fumiyuki SHIRAI, Hisashi TAKASUGI
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Patent number: 7465731Abstract: A compound having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is arylene, heterorarylene, cycloalkylene, heterocycloalkylene or aryl-fused cycloalkene, Y is arylene, heteroarylene, which may be substituted with one or more suitable substituent(s), Z lower alenylene, which may be substituted with lower alkyl or halogen, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.Type: GrantFiled: August 9, 2005Date of Patent: December 16, 2008Assignee: Astellas Pharma Inc.Inventors: Naoki Ishibashi, Yuki Sawada, Yasuharu Urano, Shigeki Satoh, Yoshikazu Inoue, Yoshiteru Eikyu, Koichiro Mukoyoshi, Kazunori Kamijo, Fumiyuki Shirai, Hisashi Takasugi
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Patent number: 7249883Abstract: A deep-area temperature calculating device 441 calculates the temperature Tcore of a deep area on the basis of a first body-surface temperature and second body-surface temperature from body-surface sensors 31A and 31B, and on the basis of a first intermediate temperature and second intermediate temperature from intermediate sensors 32A and 32B. Since the temperature Tcore of the deep area is determined from two body-surface temperatures and two intermediate temperatures, the temperature Tcore of the deep area can be calculated regardless of the heat resistance of the thermometer without making any assumptions regarding the heat resistance of the area that extends from the deep area of the human body to the body surface. Thereby, the temperature Tcore of the deep area can be calculated and the body temperature can be measured with high precision regardless of differences in the body type or contact with clothing or bedding.Type: GrantFiled: September 13, 2005Date of Patent: July 31, 2007Assignee: Seiko Epson CorporationInventors: Masao Kuroda, Naoki Ishibashi, Yutaka Kobayashi
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Patent number: 7135493Abstract: A compound having the following formula (I): wherein R1 is N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), R2 is hydroxyamino, R3 is hydrogen or a suitable substituent, L1 is ā(CH2)nā (wherein n is an integer of 0 to 6) optionally substituted with one or more suitable substituent(s), wherein one or more methylene(s) may be replaced with suitable heteroatom(s), and L2 is lower alkenylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.Type: GrantFiled: January 12, 2004Date of Patent: November 14, 2006Assignee: Astellas Pharma Inc.Inventors: Yasuharu Urano, Shigeki Satoh, Naoki Ishibashi, Kazunori Kamijo
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Patent number: 7129243Abstract: The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof.Type: GrantFiled: December 18, 2001Date of Patent: October 31, 2006Assignee: Astellas Pharma Inc.Inventors: Ichiro Shima, Takehiko Ohkawa, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
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Patent number: 7060721Abstract: Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.Type: GrantFiled: December 20, 1999Date of Patent: June 13, 2006Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Noriko Oku, legal representative, Chikako Oku, legal representative, Tomohito Oku, legal representative, Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada, Naoki Ishibashi, Hiroyuki Setoi, Noritsugu Yamasaki, Takafumi Imoto, Takahiro Hiramura, Teruo Oku, deceased
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Publication number: 20060056487Abstract: A deep-area temperature calculating device 441 calculates the temperature Tcore of a deep area on the basis of a first body-surface temperature and second body-surface temperature from body-surface sensors 31A and 31B, and on the basis of a first intermediate temperature and second intermediate temperature from intermediate sensors 32A and 32B. Since the temperature Tcore of the deep area is determined from two body-surface temperatures and two intermediate temperatures, the temperature Tcore of the deep area can be calculated regardless of the heat resistance of the thermometer without making any assumptions regarding the heat resistance of the area that extends from the deep area of the human body to the body surface. Thereby, the temperature Tcore of the deep area can be calculated and the body temperature can be measured with high precision regardless of differences in the body type or contact with clothing or bedding.Type: ApplicationFiled: September 13, 2005Publication date: March 16, 2006Applicant: Seiko Epson CorporationInventors: Masao Kuroda, Naoki Ishibashi, Yutaka Kobayashi
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Publication number: 20060052599Abstract: A compound having the following formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower) alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is arylene, heteroarylene, cycloalkylene, heterocycloalkylene or aryl-fused cycloalkylene, Y is arylene or heteroarylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.Type: ApplicationFiled: August 9, 2005Publication date: March 9, 2006Applicant: Astellas Pharma Inc.Inventors: Naoki Ishibashi, Yuki Sawada, Yasuharu Urano, Shigeki Satoh, Yoshikazu Inoue, Yoshiteru Eikyu, Koichiro Mukoyoshi, Kazunori Kamijo, Fumiyuki Shirai, Hisashi Takasugi
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Patent number: 6890934Abstract: The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.Type: GrantFiled: February 10, 2003Date of Patent: May 10, 2005Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Noriko Oku, Chikaka Oku, Tomohiro Oku, Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada, Naoki Ishibashi, Hiroyuki Setoi, Noritsugu Yamasaki, Takafumi Imoto, Takahiro Hiramura, Teruo Oku
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Publication number: 20040266826Abstract: A compound of the formula: in which R1 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted bicyclic heterocyclic group, optionally substituted lower alkenyl or optionally substituted lower alkynyl, and R2 is carboxy or protected carboxy, or a salt thereof, useful for treating and/or preventing MMP- or TNF-&agr; mediated diseases.Type: ApplicationFiled: February 27, 2004Publication date: December 30, 2004Inventors: Masahiro Neya, Akihiko Sawada, Kazuhiko Ohne, Yoshito Abe, Tsuyoshi Mizutani, Naoki Ishibashi, Makoto Inoue
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Patent number: 6825200Abstract: The present invention a compound represented by the formula (I): where the structural variables R1-R6 are defined herein.Type: GrantFiled: May 6, 2002Date of Patent: November 30, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ichiro Shima, Takehiko Ohkawa, Kazuhiko Ohne, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
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Publication number: 20040229889Abstract: A compound having the following formula (I): 1Type: ApplicationFiled: January 12, 2004Publication date: November 18, 2004Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.Inventors: Yasuharu Urano, Shigeki Satoh, Naoki Ishibashi, Kazunori Kamijo
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Publication number: 20040097425Abstract: The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.Type: ApplicationFiled: December 23, 2003Publication date: May 20, 2004Inventors: Ichiro Shima, Takehiko Ohkawa, Kentaro Sato, Naoki Ishibashi, Kenichiro Imamura
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Publication number: 20030171396Abstract: The present invention relates to a sulfonamide compound of the formula (I): 1Type: ApplicationFiled: February 10, 2003Publication date: September 11, 2003Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Teruo Oku, Noriko Oku, Chikako Oku, Tomohito Oku, Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada, Naoki Ishibashi, Hiroyuki Setoi, Noritsugu Yamasaki, Takafumi Imoto, Takahiro Hiramura
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Patent number: 6573274Abstract: The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.Type: GrantFiled: September 12, 2001Date of Patent: June 3, 2003Assignee: Fujisawa Pharmaceutical Co. Ltd.Inventors: Teruo Oku, Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada, Naoki Ishibashi, Hiroyuki Setoi, Noritsugu Yamasaki, Takafumi Imoto, Takahiro Hiramura
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Patent number: 6154764Abstract: An electronic conference system in which a plurality of users post and read messages includes a message-deletion unit for deleting posted messages so that no access can be made to deleted messages. The electronic conference system further includes a deleted-message-information-management unit for storing identification information of the deleted messages.Type: GrantFiled: July 9, 1997Date of Patent: November 28, 2000Assignee: Fujitsu LimitedInventors: Minoru Nitta, Tetsuya Suehisa, Naoki Ishibashi, Katsuhiko Tomita