Abstract: An integrated respiratory pressure therapy device and humidifier for pressurising and humidifying breathable air to treat a respiratory disorder in a patient, includes a blower configured to pressurise the breathable air; a water reservoir configured to hold a volume of water to be used for humidification of the breathable air, the water reservoir comprising a water reservoir base, a water reservoir lid connected to the water reservoir base, and a compliant portion. The compliant portion is constructed from an elastomeric material and configured to seal between the water reservoir base and the water reservoir lid. A water reservoir dock forms a cavity configured to partially receive the water reservoir. The water reservoir lid includes a protrusion and the water reservoir dock includes a recess configured to releasably engage one another to secure the water reservoir to the water reservoir dock.

Abstract: An air delivery tube for a CPAP system includes a first end configured to connect to a flow generator of the CPAP system and a second end configured to connect to a patient interface of the CPAP system. The air delivery tube also includes a central lumen that is formed by an inner wall of the air delivery tube and is configured to convey pressurized breathable gas from the first end to the second end. In addition, a circumferential chamber surrounds the central lumen and is configured to retain a supply of water. A wick is located within the central lumen and is connected to the inner wall.

Abstract: The invention features sublingual formulations of apomorphine and apomorphine prodrugs, and methods of treating Parkinson's disease, sexual dysfunction, and depressive disorders therewith.

Abstract: A gas conduit for respiratory apparatus includes a lumen for passage of a breathable gas to a patient and a flexible conduit wall surrounding the lumen. The flexible conduit wall has a humidification apparatus for delivering water vapour into the gas passing through the lumen.

Abstract: A PAP system for delivering breathable gas to a patient includes a flow generator to generate a supply of breathable gas to be delivered to the patient; a humidifier including a heating plate to vaporize water and deliver water vapor to humidify the supply of breathable gas; a heated tube configured to heat and deliver the humidified supply of breathable gas to the patient; a power supply configured to supply power to the heating plate and the heated tube; and a controller configured to control the power supply to prevent overheating of the heating plate and the heated tube.

Abstract: An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

Abstract: A system for optimizing manufacturing utilization is disclosed. The system includes a manufacturing apparatus configured to transmit a first electronic message type indicating a time period when the manufacturing apparatus is in use, as well as a sensor disposed in a work cell associated with the manufacturing apparatus, the sensor configured to transmit a second electronic message type indicating a time period of operator activity within the work cell. The system further includes a computing device configured to receive the first and second electronic message types and accumulate one or more of each of the respective time periods of the first and second electronic message types. The computing device determines utilization of the manufacturing apparatus based on accumulated time periods corresponding to the first electronic message type as a percentage of accumulated time periods corresponding to the second electronic message type.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: A PAP system for delivering breathable gas to a patient includes a flow generator to generate a supply of breathable gas to be delivered to the patient; a humidifier including a heating plate to vaporize water and deliver water vapor to humidify the supply of breathable gas; a heated tube configured to heat and deliver the humidified supply of breathable gas to the patient; a power supply configured to supply power to the heating plate and the heated tube; and a controller configured to control the power supply to prevent overheating of the heating plate and the heated tube.

Abstract: A method of authenticating a second electronic device at a first electronic device, the method comprising: providing at the second electronic device a memory, the memory comprising a first memory portion which has restricted access and is readable only when a first secret key is presented to the second electronic device; sending the first secret key from the first electronic device to the second electronic device; in response, sending a second secret key stored in the first memory portion from the second electronic device to the first electronic device; and authenticating the second secret key at the first electronic device.

Abstract: An automated dental drill includes a dental drill housing that includes a mouthpiece housing section and a one or more degrees of freedom drive housing section; an end effector drive support having a shaft section that is at least partially positioned in the mouth piece housing section, and an end effector for the cutting of a native tooth or dental appliance to a desired tolerance. The end effector is positioned on the end effector drive support. The automated dental drill also includes a power source that drives the end effector and is coupled to the end effector and a one or more degrees of freedom drive assembly to direct the end effector along one or more degrees of freedom relative to the mouth piece housing section.

Abstract: An online system presenting content items to a user generates a model that predicts a latent metric describing user actions that occur at least a reasonable amount of time after presentation of content items. To determine the latent metric, the online system retrieves one or more models predicting likelihoods of the user performing various interactions when presented with the content items and determines weights associated with different retrieved models. Combining the weighted retrieved models generates a model for determining the latent metric. As the retrieved models are based on data accessible to the online system in less than the reasonable amount of time after presenting content items, weighing the retrieved models allows the online system to predict the latent metric describing user actions occurring after content items are presented. When selecting content items for the user, the online system accounts for the latent metric determined by the generated model.

Abstract: An apparatus and method for automated dental treatment having a tooth clamp (48, 700) which connects an automated dental drill (10). The tooth clamp (700) has a rigid frame (704A, 704B) with a coupling point (703) for reversibly coupling the tooth clamp (700) to an automated dental drill (10) and a pair of jaws (701A, 701B) for coupling the clamp to a tooth of a user. A first jaw surface has a shape adapted to mate the tooth surface and is fabricated based on surface data or a three-dimensional model of the scanned tooth. The tooth clamp (700) has suction ports (702) and the system (900) has irrigation nozzles (903).

Abstract: The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

Abstract: A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises a humidifier including a water reservoir.

Abstract: A gas conduit for respiratory apparatus includes a lumen for passage of a breathable gas to a patient and a flexible conduit wall surrounding the lumen. The flexible conduit wall has a humidification apparatus for delivering water vapour into the gas passing through the lumen.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: Systems and methods have been developed for implementation of a breath testing system for convenient sampling of intestinal gases exhaled from a patient's breath. This may include a system with a manifold that includes thermal regulation components, for instance thermistors and resistive heating elements, which maintain the temperature of the gases above the body temperature of the patient. In some examples, the system will determine an indication of whether a patient has SIBO by adjusting a change in exhaled hydrogen concentration by a methane level exhaled by a patient.

Abstract: A flow generator includes a blower, a flow generator outlet configured to receive an end of a gas delivery tube, and a controller. The flow generator outlet includes electrical connectors configured to contact corresponding electrical connectors associated with the breathable gas delivery tube when the breathable gas delivery tube is received by the flow generator outlet. The controller includes a tube-type detect circuit and is configured to receive signals from the breathable gas delivery tube by way of the electrical connectors of the flow generator outlet. The tube-type detect circuit is configured so that when the breathable gas delivery tube is received by the flow generator outlet, the tube-type detect circuit determines the type of breathable gas delivery tube based on signals from the electrical connectors of the flow generator outlet that are indicative of a condition of a resistor associated with the breathable gas delivery tube.

Abstract: A dispersible wet wipe includes a layer of cellulosic fibers. In one embodiment, a first binder is applied in a coating comprising randomly distributed deposits of the binder. A second binder is applied in an intermittent pattern on the surface to define first regions on the surface that include first binder but no second binder and to define second regions on the surface that include both first binder and second binder. The first and second binders can have the same chemical composition. In a second embodiment, a first binder is applied to a web surface in a first pattern, and, after applying the first binder, a second binder is applied to the web surface in a second pattern that is different than the first pattern. In a third embodiment, a binder is applied to a web surface in a pattern, the pattern having first regions and second regions, wherein the add-on level of the binder in the first regions is lower than the add-on level of the binder in the second regions.