Abstract: A humidifier tub for a respiratory apparatus is configured to deliver pressurized breathable gas to a patient's airways. The humidifier tub includes a base and a side wall defining a reservoir for containing a supply of liquid to be evaporated. In addition, the container is made of a first material. The humidifier tub also includes a heating element provided inside the container and covered by a layer. The layer includes a second material different from the first material.

Abstract: A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system.

Abstract: A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises an integrated humidifier including a water reservoir. An RPT device is also disclosed that includes a wireless data communication interface integrated with the housing and configured to connect to another device or a network.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable and dispersible. The products generally have a Slosh time less than 2 minutes, such as less than about 60 seconds, such as less than about 45 seconds. Surprisingly, the foregoing Slosh times are achieved despite the tissue products having relatively high cross-machine direction (CD) wet tensile strength, such as greater than about 100 g/3?. Typically, increasing wet tensile strength, particularly wet CD tensile strength, negatively effects dispersability and increases Slosh time. Despite this trend, the present invention surprisingly provides a tissue product having a relatively high degree of wet strength and good dispersability.

Abstract: An integrated respiratory pressure therapy device and humidifier for pressurising and humidifying breathable air to treat a respiratory disorder in a patient, includes a blower configured to pressurise the breathable air; a water reservoir configured to hold a volume of water to be used for humidification of the breathable air, the water reservoir comprising a water reservoir base, a water reservoir lid connected to the water reservoir base, and a compliant portion. The compliant portion is constructed from an elastomeric material and configured to seal between the water reservoir base and the water reservoir lid. A water reservoir dock forms a cavity configured to partially receive the water reservoir. The water reservoir lid includes a protrusion and the water reservoir dock includes a recess configured to releasably engage one another to secure the water reservoir to the water reservoir dock.

Abstract: A respiratory apparatus is configured to deliver breathable gas to a patient's airways and includes a flow generator configured to pressurize the breathable gas and a humidifier configured to vaporize water and deliver water vapor to humidify the breathable gas. The respiratory apparatus further includes a gas flow path leading from the flow generator to the humidifier and from the humidifier to a patient interface. A continuous heater is positioned within the gas flow path and includes multiple separately controllable heating zones.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable, smooth and with low levels of Slough. In certain instances the creped tissue product have a geometric mean tensile (GMT) from about 700 to about 1,500 g/3?, a basis weight from about 45 to about 60 gsm and a Slough less than about 2.00 mg, more preferably less than about 1.50 mg, such as from about 0.10 to about 2.00, such as from about 0.25 to about 1.50 mg. The inventive tissue products also have good durability, such as a Durability Index from about 10.0 to about 20.0, smooth surfaces, such as a TS750 value from about 15.0 to 40.0 and low stiffness, such as a Stiffness Index less than about 10.0.

Abstract: A heated conduit is configured to connect to and receive pressurized breathable gas from a respiratory unit. The heated conduit includes a first cuff that includes an air inlet portion and an electrical connector portion that is adjacent the air inlet portion and comprises three electrical terminals that are configured to engage a respiratory unit electrical connector. The heated conduit also includes a second cuff comprising an air outlet and a flexible tube portion with a first end connected to the first cuff, a second end connected to the second cuff, and a spiral rib structure wrapped around a central lumen. A grouping of wires is supported within the spiral rib structure of the flexible tube portion and include a pair of heating wires and a signal wire. A sensing device extends into the gas flow path from an interior surface of the second cuff and is configured to output a signal indicative of the condition inside the heated conduit.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: A gas conduit for respiratory apparatus includes a lumen for passage of a breathable gas to a patient and a flexible conduit wall surrounding the lumen. The flexible conduit wall has a humidification apparatus for delivering water vapour into the gas passing through the lumen.

Abstract: A control system includes a refrigerant recovery module and at least one of a valve control module and a compressor control module. The refrigerant recovery module is configured to generate a refrigerant recovery signal to initiate a recovery of refrigerant from a first heat exchanger of a thermal system for an electric vehicle, and to stop the refrigerant recovery based on a temperature of refrigerant circulating through the first heat exchanger. The valve control module is configured to open a first valve to allow refrigerant to flow through the first heat exchanger in response to the refrigerant recovery signal. The compressor control module is configured to increase a speed of a compressor disposed upstream from the first heat exchanger in response to the refrigerant recovery signal.

Abstract: A container filling valve may include a shuttle and a drive sleeve that are magnetically coupled. Movement of the drive sleeve may move the shuttle from a position in which the filling valve is closed to a position in which the filling valve is open. A container handling arm may include a distal end configured to hold a container and a proximal end that includes a load cell. A low flow setpoint system may be configured to arrest closing of a filling valve when that filling valve is partially closed. A pressure control system may be configured to maintain a desired pressure in a reservoir or in a flow path from that reservoir. A product recirculation system may be configured to adjust flow rate in the product recirculation system.

Abstract: A water reservoir includes a water reservoir base configured to hold a volume of water to be used for humidification of pressurized breathable air, a water reservoir lid connected to the water reservoir base, and a compressible resilient portion configured to seal between the water reservoir base and the water reservoir lid. The base and the lid are movable relative to one another when connected whilst maintaining sealing therebetween due to the compressible resilient portion. A retainer is configured to secure the water reservoir to a water reservoir dock, and has a protrusion or recess to releasably engage one another when the water reservoir is received in the dock, with a reaction force to compression of the compressible resilient portion urging the protrusion and the recess into engagement with one another.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable and dispersible. The products generally have a Slosh time less than 2 minutes, such as less than about 60 seconds, such as less than about 45 seconds. Surprisingly, the foregoing Slosh times are achieved despite the tissue products having relatively high cross-machine direction (CD) wet tensile strength, such as greater than about 100 g/3?. Typically, increasing wet tensile strength, particularly wet CD tensile strength, negatively effects dispersability and increases Slosh time. Despite this trend, the present invention surprisingly provides a tissue product having a relatively high degree of wet strength and good dispersability.

Abstract: The present disclosure relates to compounds that are capable of modulating calcium ion homeostasis and treating disorders related thereto. The disclosure further relates to methods of making the aforementioned compounds.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable, smooth and with low levels of Slough. In certain instances the creped tissue product have a geometric mean tensile (GMT) from about 700 to about 1,500 g/3?, a basis weight from about 45 to about 60 gsm and a Slough less than about 2.00 mg, more preferably less than about 1.50 mg, such as from about 0.10 to about 2.00, such as from about 0.25 to about 1.50 mg. The inventive tissue products also have good durability, such as a Durability Index from about 10.0 to about 20.0, smooth surfaces, such as a TS750 value from about 15.0 to 40.0 and low stiffness, such as a Stiffness Index less than about 10.0.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: A heatable conduit for use in a respiratory apparatus for delivering breathable gas to a patient includes a first segment comprising one or more heater wires and a second segment comprising one or more heater wires. Each of the first and second segments comprises a spirally wound elongate body. In addition, the one or more heater wires of the first and second segments are configured to be connected in use to at least one controller such that, in a first mode, power is provided to the one or more heater wires of the first segment and no power is provided to the one or more heater wires of the second segment.