Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: A control system includes a refrigerant recovery module and at least one of a valve control module and a compressor control module. The refrigerant recovery module is configured to generate a refrigerant recovery signal to initiate a recovery of refrigerant from a first heat exchanger of a thermal system for an electric vehicle, and to stop the refrigerant recovery based on a temperature of refrigerant circulating through the first heat exchanger. The valve control module is configured to open a first valve to allow refrigerant to flow through the first heat exchanger in response to the refrigerant recovery signal. The compressor control module is configured to increase a speed of a compressor disposed upstream from the first heat exchanger in response to the refrigerant recovery signal.

Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: Liquid resin compositions that can be used in the manufacture of composite materials are described. A method of making a fiber-reinforced polymeric composite material comprises wetting a fibrous material with a liquid prepolymer composition comprising at least one (meth)acrylic monomer, at least one base, and at least one peroxy ester; and polymerizing the liquid prepolymer composition to form a fiber-reinforced polymeric composite material.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable, smooth and with low levels of Slough. In certain instances the creped tissue product have a geometric mean tensile (GMT) from about 700 to about 1,500 g/3?, a basis weight from about 45 to about 60 gsm and a Slough less than about 2.00 mg, more preferably less than about 1.50 mg, such as from about 0.10 to about 2.00, such as from about 0.25 to about 1.50 mg. The inventive tissue products also have good durability, such as a Durability Index from about 10.0 to about 20.0, smooth surfaces, such as a TS750 value from about 15.0 to 40.0 and low stiffness, such as a Stiffness Index less than about 10.0.

Abstract: A tub is configured to contain a supply of water and is configured to be inserted into a chamber of a humidifier. The tub includes a tub base configured to contain the supply of water. The tub also includes a tub lid and a flow plate provided between the tub base and the tub lid. The flow plate includes a water level indicator configured to indicate a level of the supply of water in the tub base. In addition, the water level indicator includes a generally rectangular portion and a generally triangular portion.

Abstract: A reservoir configured to retain a volume of liquid for use in an apparatus for humidifying a flow of pressurised air comprises a base portion and a lid portion. The reservoir may be configured to improve its level of thermal contact to the heater plate using the flow of pressurised air. The reservoir may be configured to improve thermal contact between the reservoir and the heater plate by pre-compression upon engagement of the reservoir with the humidifier. The reservoir may comprise a removable intermediate portion, which may include the inlet tube and/or the outlet tube, for improved access for cleaning. The reservoir may also be configured to prevent overfilling. Overfill prevention features in the reservoir may include defined flow egress paths and/or formation of air locks.

Abstract: A PAP system for delivering breathable gas to a patient includes a flow generator to generate a supply of breathable gas to be delivered to the patient; a humidifier including a heating plate to vaporize water and deliver water vapor to humidify the supply of breathable gas; a heated tube configured to heat and deliver the humidified supply of breathable gas to the patient; a power supply configured to supply power to the heating plate and the heated tube; and a controller configured to control the power supply to prevent overheating of the heating plate and the heated tube.

Abstract: Provided herein are platforms and methods for mapping a three-dimensional (3D) dental anatomy of a subject.

Abstract: A respiratory pressure therapy (RPT) device for pressurising breathable air to treat a respiratory disorder in a patient includes a pressure generator configured to pressurise breathable air, an RPT device inlet configured to receive breathable air from externally of the RPT device to be pressurised by the pressure generator, an RPT device outlet configured to be connected to an air circuit to direct breathable air pressurised by the pressure generator to the patient, a dock having a dock outlet and a dock inlet, and an external housing to enclose the pressure generator. The external housing forms an opening sized to alternatively receive an end cap or a water reservoir.

Abstract: A method of treating a disease or condition in a subject in need thereof is disclosed. The method comprising: trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject by orally administering an ingestible device comprising the dispensable substance to the subject. The ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist. The ingestible device releases the dispensable substance as at least one jet to a desired location of the GI tract of the subject.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable and dispersible. The products generally have a Slosh time less than 2 minutes, such as less than about 60 seconds, such as less than about 45 seconds. Surprisingly, the foregoing Slosh times are achieved despite the tissue products having relatively high cross-machine direction (CD) wet tensile strength, such as greater than about 100 g/3?. Typically, increasing wet tensile strength, particularly wet CD tensile strength, negatively effects dispersability and increases Slosh time. Despite this trend, the present invention surprisingly provides a tissue product having a relatively high degree of wet strength and good dispersability.

Abstract: A water reservoir includes a reservoir base configured to hold a predetermined maximum volume of water to be used for humidification of pressurized breathable air, a reservoir lid pivotally connected to the reservoir base to allow the water reservoir to be movable between an open position and a closed position, the reservoir lid comprising an inlet and an outlet, and a seal configured to sealingly engage the reservoir lid and the reservoir base when the water reservoir is in the closed position, wherein the reservoir base includes an overfill protection element having an egress path for water at a predetermined location.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable, smooth and with low levels of Slough. In certain instances the creped tissue product have a geometric mean tensile (GMT) from about 700 to about 1,500 g/3? a basis weight from about 45 to about 60 gsm and a Slough less than about 2.00 mg, more preferably less than about 1.50 mg, such as from about 0.10 to about 2.00, such as from about 0.25 to about 1.50 mg. The inventive tissue products also have good durability, such as a Durability Index from about 10.0 to about 20.0, smooth surfaces, such as a TS750 value from about 15.0 to 40.0 and low stiffness, such as a Stiffness Index less than about 10.0.

Abstract: A water reservoir includes a water reservoir base configured to hold a volume of water to be used for humidification of pressurized breathable air, a water reservoir lid connected to the water reservoir base, and a compressible resilient portion configured to seal between the water reservoir base and the water reservoir lid. The base and the lid are movable relative to one another when connected whilst maintaining sealing therebetween due to the compressible resilient portion. A retainer is configured to secure the water reservoir to a water reservoir dock, and has a protrusion or recess to releasably engage one another when the water reservoir is received in the dock, with a reaction force to compression of the compressible resilient portion urging the protrusion and the recess into engagement with one another.

Abstract: The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.

Abstract: This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.

Abstract: A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises an integrated humidifier including a water reservoir. An RPT device is also disclosed that includes a wireless data communication interface integrated with the housing and configured to connect to another device or a network.

Abstract: Disclosed are non-treated, creped tissue webs, and tissue products produced therefrom, having low stiffness and surface lint. The inventive products may be produced by a print creping process adapted to dispose a non-crosslinked latex polymer on at least one of the outer surfaces of the tissue product. The non-crosslinked latex polymer creping composition does not negatively affect stiffness such that the products generally have a Stiffness Index less than about 5.0, such as from about 2.5 to about 5.0.

Abstract: A respiratory pressure therapy (RPT) device is disclosed for treatment of respiratory-related disorders. The RPT device includes a pressure generator, a pneumatic block, a chassis and a device outlet for delivering a supply of flow of gas to a patient interface. The RPT device also comprises an integrated humidifier including a water reservoir. An RPT device is also disclosed that includes a wireless data communication interface integrated with the housing and configured to connect to another device or a network.