Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.

Abstract: This disclosure provides systems, methods and apparatus, including computer programs encoded on computer storage media, for adjusting a packet duration for triggered uplink (UL) transmissions to an access point (AP) from one or more stations (STAs). In one aspect, the AP may estimate an amount of data that a STA has queued for UL transmission and select the packet duration based on the estimated amount of queued UL data. The AP may transmit a trigger frame that solicits UL data from the STA and indicates the selected packet duration. In response, the AP may receive an UL packet from the STA and determine an amount of UL data queued in the STA based on the UL packet. In some implementations, the AP may selectively adjust the packet duration for UL transmissions based on the UL packet, the determined amount of UL data queued in the STA, or both.

Abstract: Systems and methods for selectively enabling multi-user (MU) communications are disclosed. In some implementations, an access point (AP) obtains packets associated with a traffic flow, and obtains at least one of service-level agreement (SLA) parameters associated with the traffic flow, attributes of the traffic flow, or network parameters associated with a basic service set (BSS) that includes the AP. The AP provides an indication of whether the traffic flow is suitable for transmission as a single-user (SU) multiple-input multiple output (MIMO) (SU-MIMO) communication, as an MU-MIMO communication, as an orthogonal frequency division multiple access (OFDMA) communication, or as a partial bandwidth (BW) MU-MIMO communication to a WLAN subsystem of the AP, the indication being based on one or more of the SLA parameters, the traffic flow attributes, or the network parameters. The AP initiates transmission of the one or more packets based on the indication.

Abstract: Apparatus includes a sample holder with a cavity and a plurality of devices configured to hold a curvature of a curved substrate in a fixed configuration. Apparatus includes two prisms with a viewing apparatus of the sample holder configured to translate therebetween. Methods can include disposing the curved substrate in the sample holder, transmitting a first beam, translating the sample holder, and transmitting a second beam. Alternatively, apparatus include a light scattering-polarimetry sub-system configured to emit a first beam to impinge an end surface of coupling prism and detect at least a portion of the first beam impinging the first surface of the coupling prism. The apparatus includes an evanescent prism coupling spectroscopy sub-system configured to emit a second beam to impinge a first surface of the coupling system and detect at least a portion of the second beam impinging the second surface of the coupling prism.

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

Abstract: The present disclosure relates to systems, devices and methods for receiving biosensor data acquired by a medical device, e.g., relating to glucose concentration values, and controlling the access and distribution of that data. In some embodiments, systems and methods are disclosed for monitoring glucose levels, displaying data relating to glucose values and metabolic health information, and controlling distribution of glucose data between applications executing on a computer, such as a smart phone. In some embodiments, systems and methods are disclosed for controlling access to medical data such as continuously monitored glucose levels, synchronizing health data relating to glucose levels between multiple applications executing on a computer, and/or encrypting data.

Abstract: The present disclosure relates to systems, devices and methods for receiving biosensor data acquired by a medical device, e.g., relating to glucose concentration values, and controlling the access and distribution of that data. In some embodiments, systems and methods are disclosed for monitoring glucose levels, displaying data relating to glucose values and metabolic health information, and controlling distribution of glucose data between applications executing on a computer, such as a smart phone. In some embodiments, systems and methods are disclosed for controlling access to medical data such as continuously monitored glucose levels, synchronizing health data relating to glucose levels between multiple applications executing on a computer, and/or encrypting data.

Abstract: Systems and methods are provided to determine a time to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a model or pattern. The time to deliver guidance may be calculated to be useful to a user in the management of a glucose concentration level.

Abstract: The present disclosure relates to systems, devices and methods for receiving biosensor data acquired by a medical device, e.g., relating to glucose concentration values, and controlling the access and distribution of that data. In some embodiments, systems and methods are disclosed for monitoring glucose levels, displaying data relating to glucose values and metabolic health information, and controlling distribution of glucose data between applications executing on a computer, such as a smart phone. In some embodiments, systems and methods are disclosed for controlling access to medical data such as continuously monitored glucose levels, synchronizing health data relating to glucose levels between multiple applications executing on a computer, and/or encrypting data.

Abstract: A system includes a nozzle configured to eject a liquid. The system also includes a wall having a surface facing the nozzle, and a thickness extending from the surface. The system also includes one or more capacitance sensors configured to detect, through the thickness of the wall, a presence of the liquid at or adjacent to the surface.

Abstract: A lampshade ring assembly, a lampshade apparatus including the lampshade ring assembly and a lampshade, and a method of assembling the same. The lampshade ring assembly may include a mounting hub having a plurality of first mounting elements arranged in a spaced apart manner, an outer ring having a plurality of second mounting elements arranged in a spaced apart manner, and a plurality of connectors each having a first end with a third mounting element and a second end with a fourth mounting element. The connectors may be detachably coupled to: (1) the mounting hub via engagement between the first mounting elements and the third mounting element; and (2) the outer ring via engagement between the second mounting elements and the fourth mounting element. The outer ring may be configured to be coupled to a lampshade and the mounting hub may be configured to be coupled to a light fixture.

Abstract: Systems and methods to record, process, and finalize documents such as forms from customized form input data into submission-ready selectable document forms are provided. Data entries are received and mapped to a set of user-defined data field templates. Data mutation export actions are performed to bring data entries into conformance with requirements of the submission-ready selectable document form.

Abstract: A rotating climbing wall can include a frame assembly with uprights forming rails. Slats of a slat assembly can include coupling blocks that are configured to ride along the rails of the uprights. At least one upright can include a power rail that extends alongside the rail. Electrical contacts can be integrated into the coupling blocks to form an electrical connection with the power rail as the respective slats ride along the rails. The electrical connection can be used to power lights that are integrated into the slats and that illuminate holds. The rotating climbing may include actuators that automatically tension chains used to rotate the climbing surface of the rotating climbing wall. The actuators, which may be linear actuators, can detect a level of tension in the chains and, if the tension is below a threshold, increase the distance between sprockets that drive the chains to increase the tension.

Abstract: A lampshade ring assembly, a lampshade apparatus including the lampshade ring assembly and a lampshade, and a method of assembling the same. The lampshade ring assembly may include a mounting hub having a plurality of first mounting elements arranged in a spaced apart manner, an outer ring having a plurality of second mounting elements arranged in a spaced apart manner, and a plurality of connectors each having a first end with a third mounting element and a second end with a fourth mounting element. The connectors may be detachably coupled to: (1) the mounting hub via engagement between the first mounting elements and the third mounting element; and (2) the outer ring via engagement between the second mounting elements and the fourth mounting element. The outer ring may be configured to be coupled to a lampshade and the mounting hub may be configured to be coupled to a light fixture.

Abstract: A scattered light polarimetry (LSP) sub-system of a hybrid system for characterizing stress in a chemically-strengthened (CS) substrate having a top-surface and a near-surface waveguide, includes a LSP light source system, an LSP light source actuator coupled to the LSP light source system, and an optical compensator within an optical path of a LSP laser beam emitted by the LSP light source system. The optical compensator includes a half-wave plate, a half-wave plate actuator, a diffuser, and a diffuser actuator. The LSP sub-system further includes a LSP detector system in optical communication with the optical compensator through an LSP coupling prism having a LSP coupling surface, a focusing lens and a focusing lens actuator, and a support plenum having a surface and a measurement aperture, the support plenum configured to support the CS substrate at a measurement plane at the measurement aperture, and to operably support the LSP coupling prism.

Abstract: A method for predicting an incoming rotational balance of an unfinished workpiece includes obtaining image data of the unfinished workpiece, generating a virtual representation of the unfinished workpiece based on the image data, segmenting the virtual representation into one or more target meshes, determining one or more parameters of the one or more target meshes, where the one or more parameters comprise a volume, a center of gravity, or a combination thereof, and determining a balance metric of the unfinished workpiece based on the one or more parameters and a balance prediction model.

Abstract: This disclosure provides systems, methods and apparatus, including computer programs encoded on computer storage media, for adjusting a packet duration for triggered uplink (UL) transmissions to an access point (AP) from one or more stations (STAs). In one aspect, the AP may estimate an amount of data that a STA has queued for UL transmission and select the packet duration based on the estimated amount of queued UL data. The AP may transmit a trigger frame that solicits UL data from the STA and indicates the selected packet duration. In response, the AP may receive an UL packet from the STA and determine an amount of UL data queued in the STA based on the UL packet. In some implementations, the AP may selectively adjust the packet duration for UL transmissions based on the UL packet, the determined amount of UL data queued in the STA, or both.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.