Patents by Inventor Nicholas I. Carruthers

Nicholas I. Carruthers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS
    Publication number: 20100240648
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • Hexahydro-pyrrolo-isoquinoline compounds
    Patent number: 7754882
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: July 13, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • Cyclopropyl Amines as Modulators of the Histamine H3 Receptor
    Publication number: 20100130485
    Abstract: Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Application
    Filed: January 28, 2010
    Publication date: May 27, 2010
    Inventors: Brett D. Allison, Nicholas I. Carruthers, Cheryl A. Grice, Michael A. Letavic
  • Cyclopropyl amines as modulators of the histamine Hreceptor
    Patent number: 7687499
    Abstract: Certain cyclopropyl amines are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: March 30, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Brett D. Allison, Nicholas I. Carruthers, Cheryl A. Grice, Michael A. Letavic
  • Isoxazole Compounds as Histamine H3 modulators
    Publication number: 20100022539
    Abstract: Certain isoxazole compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Application
    Filed: September 15, 2009
    Publication date: January 28, 2010
    Inventors: Nicholas I. Carruthers, Chandravadan R. Shah, Devin M. Swanson
  • Heterocyclic compounds
    Patent number: 7645758
    Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: January 12, 2010
    Assignee: Janssen Pharmaceutica, N.Y.
    Inventors: Hui Cai, Nicholas I. Carruthers, Curt A. Dvorak, James P. Edwards, Annette K. Kwok, Jianmei Wei
  • NON-IMIDAZOLE ARYLOXYALKYLAMINES
    Publication number: 20100004241
    Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
    Type: Application
    Filed: August 14, 2009
    Publication date: January 7, 2010
    Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Dale A. Rudolph, Chandravadan R. Shah, Wei Xiao
  • SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
    Publication number: 20090291903
    Abstract: Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Application
    Filed: May 19, 2009
    Publication date: November 26, 2009
    Inventors: Nicholas I. Carruthers, Michael A. Letavic, Kiev S. Ly, Neelakandha S. Mani, Daniel J. Pippel, Chandravadan R. Shah, Akinola Soyode-Johnson, Emily M. Stocking, Lana Young
  • FUSED HETEROCYCLIC COMPOUNDS
    Publication number: 20090270370
    Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Application
    Filed: July 2, 2009
    Publication date: October 29, 2009
    Inventors: Nicholas I. Carruthers, Wenying Chai, Xiaohu Deng, Curt A. Dvorak, Annette K. Kwok, Jimmy T. Liang, Neelakandha Mani, Dale A. Rudolph, Victoria D. Wong
  • OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES
    Publication number: 20090263322
    Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
    Type: Application
    Filed: June 30, 2009
    Publication date: October 22, 2009
    Inventors: Richard Apodaca, Nicholas I. Carruthers, John R. Carson, Wenying Chai, Annette K. Kwok, Xiaobing Li, Timothy W. Lovenberg, Dale A. Rudolph, Chandravadan R. Shah
  • Heterocyclic compounds
    Patent number: 7504426
    Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: March 17, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nicholas I. Carruthers, Curt A. Dvorak, James P. Edwards, Cheryl A. Grice, Jill A. Jablonowski, Kiev S. Ly, Barbara A. Pio, Chandravadan R. Shah, Jennifer D. Venable
  • NON-IMIDAZOLE HETEROCYCLIC COMPOUNDS
    Publication number: 20080317671
    Abstract: Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Application
    Filed: August 20, 2008
    Publication date: December 25, 2008
    Inventors: Nicholas I. Carruthers, Chandravadan R. Shah, Devin M. Swanson
  • NON-IMIDAZOLE HETEROCYCLIC COMPOUNDS
    Publication number: 20080306066
    Abstract: Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Application
    Filed: August 6, 2008
    Publication date: December 11, 2008
    Inventors: Nicholas I. Carruthers, Chandravadan R. Shah, Devin M. Swanson
  • NON-IMIDAZOLE ARYLOXYALKYLAMINES
    Publication number: 20080306085
    Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
    Type: Application
    Filed: August 20, 2008
    Publication date: December 11, 2008
    Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Dale A. Rudolph, Chandravadan R. Shah, Wei Xiao
  • Non-imidazole aryloxyalkylamines
    Patent number: 7429586
    Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: September 30, 2008
    Assignee: Ortho-McNeil Pharmaceuticlas, Inc.
    Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Dale A. Rudolph, Chandravadan R. Shah, Wei Xiao
  • Furan compounds as histamine H modulators
    Patent number: 7429659
    Abstract: Certain furan compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: September 30, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nicholas I. Carruthers, Chandravadan R. Shah, Devin M. Swanson
  • Pyridine compounds as histamine H3 modulators
    Patent number: 7423147
    Abstract: Certain non-imidazole heterocyclic compounds are Histamine H3 modulators in the treatment of Histamine H3 receptor mediated diseases.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: September 9, 2008
    Assignee: Janssen Pharmaceutical, N.V.
    Inventors: Nicholas I. Carruthers, Chandravadan R. Shah, Devin M. Swanson
  • Naphthyridine compounds
    Patent number: 7417054
    Abstract: Certain naphthyridine compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: August 26, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nicholas I. Carruthers, John M. Keith, Michael A. Letavic, Chandravadan R. Shah
  • Fused heterocyclic compounds
    Patent number: 7402680
    Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: July 22, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Nicholas I. Carruthers, Wenying Chai, Xiaohu Deng, Curt A. Dvorak, Annette K. Kwok, Jimmy T. Liang, Neelakandha Mani, Dale A. Rudolph, Victoria D. Wong
  • NON-PEPTIDIC NPY Y2 RECEPTOR INHIBITORS
    Publication number: 20080132540
    Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 5, 2008
    Inventors: Nicholas I. Carruthers, Wenying Chai, Scott L. Dax, Jill A. Jablonowski, Xiaobing Li, Timothy W. Lovenberg, William V. Murray, Dale A. Rudolph, Mark Seierstad, Mark A. Youngman