Patents by Inventor Nicholas I. Carruthers

Nicholas I. Carruthers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED AMINOMETHYL BENZAMIDE COMPOUNDS
    Publication number: 20080045508
    Abstract: Certain substituted aminomethyl benzamide compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.
    Type: Application
    Filed: June 21, 2007
    Publication date: February 21, 2008
    Inventors: Brett Allison, Nicholas I. Carruthers, Michael P. Curtis, John M. Keith, Michael A. Letavic, Emily M. Stocking
  • SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR
    Publication number: 20080045507
    Abstract: Certain substituted benzamide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
    Type: Application
    Filed: June 21, 2007
    Publication date: February 21, 2008
    Inventors: Brett D. Allison, Nicholas I. Carruthers, Michael A. Letavic, Alejandro Santillan, Chandravadan R. Shah
  • Non-peptidic NPY Y2 receptor inhibitors
    Patent number: 7317025
    Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: January 8, 2008
    Assignee: Johnson & Johnson Pharmaceutical Research & Development, LLC
    Inventors: Nicholas I. Carruthers, Wenying Chai, Scott L. Dax, Jill A. Jablonowski, Xiaobing Li, Timothy W. Lovenberg, William V. Murray, Dale A. Rudolph, Mark Seierstad, Mark A. Youngman
  • 2-oxy, 2-amino, and 2-thio-imidazole compounds
    Patent number: 7265135
    Abstract: The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compounds and methods of using them in the treatment of neurological disorders and other disorders and conditions mediated by the histamine H3 receptor.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: September 4, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Michael Bogenstaetter, Nicholas I. Carruthers, Jill A. Jablonowski, Timothy W. Lovenberg, Kiev S. Ly
  • Non-imidazole aryloxypiperidines
    Patent number: 7241778
    Abstract: Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: July 10, 2007
    Assignee: Ortho McNeil Pharmaceutical, Inc
    Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Chandravadan R. Shah, Wei Xiao
  • Heterocyclic compounds
    Patent number: 7226938
    Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: June 5, 2007
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Hui Cai, Nicholas I. Carruthers, Curt A. Dvorak, James P. Edwards, Annette K. Kwok, Jianmei Wei
  • Phenyl-substituted imidazopyridines
    Patent number: 7199117
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: April 3, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Non-imidazole aryloxyalkylamines
    Patent number: 7186732
    Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: March 6, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Dale A. Rudolph, Chandravadan R. Shah, Wei Xiao
  • Phenyl-substituted imidazopyridines
    Patent number: 7087757
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: August 8, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Non-imidazole aryloxypiperidines
    Patent number: 7071191
    Abstract: Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: July 4, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Richard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Chandravadan R. Shah, Wei Xiao
  • Phenyl-substituted imidazopyridines
    Patent number: 7041828
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: May 9, 2006
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Phenyl-substituted imidazopyridines
    Patent number: 7041827
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: May 9, 2006
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Substituted 4-phenyl-[1,3]-dioxanes
    Patent number: 6951882
    Abstract: Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: October 4, 2005
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nicholas I Carruthers, Todd K. Jones, Xiaobing Li, Timothy W. Lovenberg, Laura C. McAtee, Victor K. Phuong, Dale A. Rudolph, Steven W. Sutton
  • Phenyl-substituted imidazopyridines
    Patent number: 6908929
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: June 21, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Heterocyclic compounds
    Patent number: 6803362
    Abstract: Heterocyclic compounds and methods of making them and using them.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: October 12, 2004
    Assignee: Ortho-McNeil Pharmaceutical inc.
    Inventors: Nicholas I. Carruthers, Wenying Chai, Curt A. Dvorak, James P. Edwards, Cheryl A. Grice, Jill A. Jablonowski, Lars Karlsson, Haripada Khatuya, Jennifer D. Kreisberg, Annette K. Kwok, Timothy W. Lovenberg, Kiev S. Ly, Barbara Pio, Chandravadan R. Shah, Siguan Sun, Robin L. Thurmond, Jianmei Wei, Wei Xiao
  • Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine
    Publication number: 20040167336
    Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
    Type: Application
    Filed: February 6, 2004
    Publication date: August 26, 2004
    Inventors: Richard Apodaca, Nicholas I. Carruthers, John R. Carson, Wenying Chai, Annette K. Kwok, Xiaobing Li, Timothy W. Lovenberg, Dale A. Rudolph, Chandravadan R. Shah
  • Heterocyclic compounds
    Publication number: 20040147577
    Abstract: Pharmaceutically useful heterocyclic compounds, compositions containing them, and methods of using them, for example, as histamine H3 receptor mediators.
    Type: Application
    Filed: January 14, 2004
    Publication date: July 29, 2004
    Inventors: Michael Bogenstaetter, Nicholas I. Carruthers, Jill A. Jablonowski, Timothy W. Lovenberg, Kiev S. Ly
  • Substituted 4-phenyl-[1,3]-dioxanes
    Publication number: 20040147593
    Abstract: Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.
    Type: Application
    Filed: December 12, 2003
    Publication date: July 29, 2004
    Inventors: Nicholas I. Carruthers, Todd K. Jones, Xiaobing Li, Timothy W. Lovenberg, Laura C. McAtee, Victor K. Phuong, Dale A. Rudolph, Steven W. Sutton
  • Heterocyclic compounds
    Publication number: 20040058934
    Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
    Type: Application
    Filed: September 4, 2003
    Publication date: March 25, 2004
    Inventors: Nicholas I. Carruthers, Curt A. Dvorak, James P. Edwards, Cheryl A. Grice, Jill A. Jablonowski, Kiev S. Ly, Barbara A. Pio, Chandravadan R. Shah, Jennifer D. Venable
  • Heterocyclic compounds
    Publication number: 20040048878
    Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 11, 2004
    Inventors: Hui Cai, Nicholas I. Carruthers, Curt A. Dvorak, James P. Edwards, Annette K. Kwok