Abstract: The present disclosure provides a payload deployment system that is operative to receive and retain a configurable payload. The payload deployment mechanism helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload may be released using a hinge mechanism to ensure the payload does not contact the payload deployment mechanism when the payload is deployed. A vent may be utilized to equalize pressure between the external environment and a body portion of the payload deployment mechanism. The vent may generate an additional force to assist in separating the payload from the launcher.

Abstract: A CRISPR-Cas9 system for treating a disease, disorder, or condition associated with one or more somatic mutations in a subject in need of treatment thereof is disclosed. The system comprises a sgRNA-guided Cas9, wherein the sgRNA targets between about 1 to about 50 mutations in a target cell. The CRISPR-Cas9 system can be used to treat diseases, disorders, or conditions associated with one or more somatic mutations, including cancers, autoimmune diseases, and/or neurodegenerative diseases. Additionally, the present disclosure relates to methods of identifying somatic mutations in a tumor that produce a protospacer adjacent motif (PAM) and methods of designing a CRISPR-Cas 9 system to target PAMs identified in a tumor sample obtained from a subject.

Abstract: An unmanned aerial vehicle with deployable components (UAVDC) may comprise a foldable propeller blade with a locking mechanism. Foldable propeller blades may have a stowed configuration and a deployed configuration relative to the UAVDC, and the foldable propeller blades may pivot about a hinge to move between configurations. In the deployed configuration, the foldable propellor may experience forward folding forces acting upon it. The locking mechanism may lock the foldable propeller blade in the deployed configuration. The locking mechanism may keep the foldable propeller locked into place to prevent forward folding tendency.

Abstract: The present disclosure provides a method for processing data using a transformer model with privacy preservation. The method includes receiving input data, applying a dimensionality reduction operation using an input privacy layer positioned horizontally between an input layer and an execution layer of the transformer model, processing the reconstructed data, generating an encryption key for encrypting weights of the input privacy layer, splitting the encryption key into shares, distributing the shares among blockchain addresses, encrypting the weights, receiving signatures from the blockchain addresses, reconstructing the encryption key using the signatures and shares, verifying the authenticity of each signature, decrypting the weights using the reconstructed key if all signatures are verified, and updating the transformer model with the decrypted weights. The input privacy layer includes down projection, transformation, and up projection operations.

Abstract: Embodiments are disclosed for performing cache aware searching. In response to a search query, a first bucket and a second bucket in remote storage for processing the search query. A determination is made that a first file in the first bucket is present in a cache when the search query is received. In response to the search query, a search is performed using the first file based on the determination that the first file is present in the cache when the search query is received, and the search is performed using a second file from the second bucket once the second file is stored in the cache.

Abstract: The present disclosure provides a system for secure compute using artificial intelligence agents. The system includes a hardware execution environment with one or more computerized processors and electronic storage media. The processors are configured to establish a secure agent comprising a secure state management module, an encrypted state transition management module, a threshold cryptography implementation, and a digital signature verification module. The system also includes a plurality of atomic agents, each configured to perform a composite task and comprising a task-specific execution module, a state management interface, and a communication module. An orchestrator agent coordinates secure execution of the atomic agents and includes a task distribution module, a result aggregation module, a workflow management module, and a security policy enforcement module.

Abstract: Data payloads from an external data storage system are processed in an observability pipeline system. In some aspects, the observability pipeline system defines a leader role and worker roles. The leader role generates a data discovery task based on configuration information for a data collection task. A worker role executes the data discovery task, which includes communicating with an external data storage system to identify a data payload that is stored on the external data storage system and contains event data that meet event filter criteria. The leader role generates data collection tasks based on the data payload. Worker roles execute the data collection tasks. Executing a data collection task includes communicating with the external data storage system to obtain a subset of filtered event data from the data payload; and streaming the subset of filtered event data to an observability pipeline process.

Abstract: A navigation system includes a plurality of information sources for use in determining a position estimate, including an inertial navigation system which determines an inertial-based position estimate, and a receiver which receives wireless signals from external transmitters. A first calculation unit repeatedly determines a first position estimate based on information derived from one or more of the information sources. A second calculation unit repeatedly determine a second position estimate based on information derived from one or more of the information sources. A selection unit repeatedly determines which of the first and second position estimates is more reliable, and selects one of these for output as an output position estimate. Over a period of time, first position estimate is determined based on a first set of information derived from one or more of the information sources, and the second position estimate is determined based on a second set of information.

Abstract: The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3?,5?-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.

Abstract: The present disclosure provides rolling release launching system that is operative to receive and retain a drone or other payload in a protected launcher. The launcher helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload is launched when a rotating door opens to expose the payload in a bay area. The rotating door may be parallel or concentric to a longitudinal axis of the body portion of the device. The payload may be launched using a biasing and fastening mechanism, which may include detachably coupling bracket, to induce an angular moment and releasing force on the payload during launch.

Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to magnetize the output coupler housing when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in an inner surface of a central opening in the output coupler housing and one or more engagement members located in the outer surface of the input shaft.

Abstract: The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.

Abstract: A universal wraparound knee brace includes a central body section having a concavely curved inside surface for engaging and extending vertically across the wearer's knee. A corresponding pair of first and second upper flaps extend from respective opposing vertical edges of the central body section and a pair of corresponding first and second lower flaps similarly extend from the opposite vertical edges of the central body section. The second upper and lower flaps carry respective interior D-rings. Each first flap is engaged with a respective interior D-ring attached to its corresponding second flap and is pulled through the D-ring in a reverse direction so that corresponding first and second flaps wrap around the wearer's leg above and below the knee. The corresponding first and second flaps are secured in place by complementary first and second hook and loop connectors. Each second flap also carries an elongate locking strap and a respective exterior D-ring attached at an inner end of the locking strap.

Abstract: Data payloads from an external data storage system are processed in an observability pipeline system. In some aspects, the observability pipeline system defines a leader role and worker roles. The leader role generates a data discovery task based on configuration information for a data collection task. A worker role executes the data discovery task, which includes communicating with an external data storage system to identify a data payload that is stored on the external data storage system and contains event data that meet event filter criteria. The leader role generates data collection tasks based on the data payload. Worker roles execute the data collection tasks. Executing a data collection task includes: communicating with the external data storage system to obtain a subset of filtered event data from the data payload; and streaming the subset of filtered event data to an observability pipeline process.

Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to magnetize the input shaft when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in the input shaft and one or more engagement members located in the inner surface of the central opening of the output coupler housing.

Abstract: The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.

Abstract: Systems and methods of the present disclosure relate to actuator assemblies for downhole tools. An actuator assembly comprises a ball screw; a ball nut disposed around the ball screw; a cam disposed around the ball nut; a rail disposed adjacent to the cam, the rail operable to stop rotation of the cam to extend the cam axially as the ball nut traverses the ball screw.

Abstract: A processing unit for automated preparation of biological samples included in specimen tubes is described herein. The processing unit includes a removable sample preparation component configured to receive specimen tubes, read identifiers associated with the biological samples contained in the specimen tubes, mix reagents included in the specimen tubes, and transfer the specimen tubes to at least one of a centrifuge or a storage compartment. The processing unit further includes a centrifuge loader for automatic loading and unloading of the specimen tubes onto a centrifuge. The automated centrifuge loader includes a magnetic brake that can stop the centrifuge rotor at a precise position to facilitate loading and unloading of a specimen tube. The centrifuge includes a swing bucket designed to pivot around an axis and slide vertically to enable moving the bucket to a position in which the swing bucket can engage with the port where the specimen tube resides.

Abstract: Embodiments provide techniques, including systems and methods, for identifying and matching requestors and providers. For example, embodiments can display an identification pattern that is unique for a matched requestor and provider to allow the providers and requestors to quickly, easily, and accurately validate one another's identities prior to a service being provided. In some embodiments, the identification element may be presented on a provider communication device to clearly display graphics associated with an identification element to all requestors in an area so that the requestors may easily identify a matched provider.