Abstract: The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3?,5?-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.

Abstract: A contact insulator for use with high speed cable with differential pairs of contacts. A contact receiving portion has contact receiving slots which open from a first side of the contact insulator. A conductor receiving portion has conductor receiving slots which open from a second side of the contact insulator. A transition portion is positioned between the contact receiving portion and the conductor receiving portion. The transition portion has a contact receiving opening which extends through the contact insulator. The contact receiving opening is dimensioned to allow the contacts to be inserted therethrough. The contact insulator is rotated about the contacts and signal conductors of the high speed cable to position the contacts in the contact receiving slots through the first side of the contact insulator and position the signal conductor in the conductor receiving slots through the second side of the contact insulator.

Abstract: The present disclosure provides rolling release launching system that is operative to receive and retain a drone or other payload in a protected launcher. The launcher helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload is launched when a rotating door opens to expose the payload in a bay area. The rotating door may be parallel or concentric to a longitudinal axis of the body portion of the device. The payload may be launched using a biasing and fastening mechanism, which may include detachably coupling bracket, to induce an angular moment and releasing force on the payload during launch.

Abstract: Disclosed are a container assembly and a food processing system (20) comprising thereof. The container assembly includes a sealable body including a chamber (32), a chamber opening (56) formed in the sealable body, and a vacuum sealing assembly (52) mounted to the sealable body adjacent the chamber opening (56). The vacuum sealing assembly (52) includes a needle valve (60) having a needle valve opening formed therein. The needle valve (60) is movable relative to the chamber opening (56) such that the needle valve opening is movable into and out of the chamber (32). A biasing mechanism (74) is operably coupled to the needle valve (60) to move the needle valve opening out of the chamber (32).

Abstract: In one embodiment, a device includes a fiber array unit (FAU) coupled to a photonics integrated circuit (PIC) die. The PIC die includes a cavity defined at an edge of the PIC die, with outer edges of the cavity being formed at an angle less than 90 degrees with respect to a bottom surface of the cavity. The PIC die further includes first waveguides protruding into the cavity of the PIC die. The FAU includes a shelf portion extending from a body portion, and a plurality of second waveguides protruding from an outer edge of the shelf portion opposite the body portion. The FAU further includes alignment structures on outer edges of the shelf portion that are in contact with the angled edges of the cavity of the PIC die.

Abstract: This disclosure relates generally to corrugated pipe, and more particularly to corrugated pipe with an outer wrap. In one embodiment, a pipe includes an axially extended bore defined by a corrugated outer wall having axially adjacent, outwardly-extending corrugation crests, separated by corrugation valleys. The pipe also includes an outer wrap applied to the outer wall. The outer wrap may include fibers and plastic. The outer wrap may span the corrugation crests producing a smooth outer surface.

Abstract: The present disclosure relates generally to displaying a visual representation of a stroke.

Abstract: Systems and methods for thermally processing composite components are provided. In one exemplary aspect, a system includes a thermal system, a mover device, and a control system. The system also includes a plurality of vessels in which one or more components may be placed. The vessels are similarly shaped and configured. A vessel containing the one or more components therein may be mounted into a chamber defined by the thermal system during thermal processing. The thermal system and vessels include features that allow components to be thermally processed, e.g., compacted, burnt-out, and densified via a melt-infiltration process, a polymer impregnation and pyrolyzing process, or a chemical vapor infiltration process. utilizing the same thermal system and common vessel design. The control system may control the thermal system and mover device to automate thermal processing of the composite components.

Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to magnetize the output coupler housing when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in an inner surface of a central opening in the output coupler housing and one or more engagement members located in the outer surface of the input shaft.

Abstract: The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.

Abstract: An assembly for terminating a high speed cable. The assembly includes a shell housing and preassembled crosstalk shield. The shell housing has a mating end and a conductor receiving end, One or more shield receiving recesses extend from the conductor receiving end toward the mating end. The preassembled crosstalk shield has mounting projections which are positioned in the one or more shield receiving recesses. The mounting projections and the one or more shield receiving recesses provide an interference engagement to provide a secure mechanical and electrical connection between the shell housing and the preassembled crosstalk shield.

Abstract: An attachment for use with a food processing system including a container body including a sidewall, a first end configured to be mounted to a food processing base, and a second end remote from said first end. The first end is open and the second end includes an end wall oriented transverse to the sidewall. A chamber is defined by said container body. A first agitating member is receivable at said first end and a second agitating member receivable at said second end. The second agitating member is extendable into said chamber from said second end.

Abstract: An orthopedic instrument, comprising a pair of pivotally-connected arms, extending beyond a pivot axis of a first pivot; a pair of feet mounted to ends of the pair of pivotally-connected arms; and a quadrilateral linkage configured to maintain parallelism between the pair of feet over a range of angles and to selectively alter a distance between the pair of feet.

Abstract: Implementations described herein relate to providing device messages in image compilations based on user content. A computer-implemented method includes determining that a playback mode is entered on a device to display one or more image compilations, each image compilation including images for successive display. Message criteria are obtained for device messages, each device message indicating a device function associated with images of the image compilations or of a user image library. A device message is selected based on associated message criteria. An image is identified in the user image library, the image being in the image compilations, depicts a type of image feature in the image compilations, and/or has characteristic(s) modifiable by the device function. The device message is displayed during image compilation playback and includes the identified image and a message control option. In response to user selection of the message control option, the device function is initiated.

Abstract: Some embodiments provide systems, assemblies, and methods of analyzing patient anatomy, including providing an analysis of a patient's spine, and also analyzing the biomechanical effects of implants. In some embodiments, the systems, assemblies, and/or methods can include obtaining initial patient data, acquiring spinal alignment and contour information, acquiring flexibility and/or biomechanical information, registering patient anatomical landmarks of interest relative to fiducial markers, analyzing databases of measurements and patient data to predict postoperative patient outcomes. Further, in some embodiments, the systems, assemblies, and/or methods can assess localized anatomical features of the patient, and obtain anatomical region data. In some embodiments, the systems, assemblies, and/or methods can also analyze the localized anatomy and therapeutic device location and contouring.

Abstract: A universal wraparound knee brace includes a central body section having a concavely curved inside surface for engaging and extending vertically across the wearer's knee. A corresponding pair of first and second upper flaps extend from respective opposing vertical edges of the central body section and a pair of corresponding first and second lower flaps similarly extend from the opposite vertical edges of the central body section. The second upper and lower flaps carry respective interior D-rings. Each first flap is engaged with a respective interior D-ring attached to its corresponding second flap and is pulled through the D-ring in a reverse direction so that corresponding first and second flaps wrap around the wearer's leg above and below the knee. The corresponding first and second flaps are secured in place by complementary first and second hook and loop connectors. Each second flap also carries an elongate locking strap and a respective exterior D-ring attached at an inner end of the locking strap.

Abstract: The systems and methods disclosed herein can increase the speed and ease with which a user can discover compatible replacement parts for a specified model of a product by automatically determining when the user is interested in replacement parts. A replacement part system can conclude that a user is looking for replacement parts based on the user's search queries, the user's browsing behavior, or the user's prior purchases. By automatically deducing an intention to purchase a replacement part, the replacement part system can make it easier for a user to locate suitable replacement parts. In addition, the replacement part system can be configured to tailor listing set of replacement parts search results it provides to a user. The set of search results can be tailored based on a number of criteria to increase the speed with which the user finds a compatible replacement part.

Abstract: A method, apparatus, and computer-readable medium for artifact attribution is provided. The method can be performed by a generative system, or generative AI. The method can include storing a proprietary artifact created by a creator and terms of use for usage of the proprietary artifact defined by the creator. The method can also include generating a new artifact based on the proprietary artifact and the user's rights to the proprietary artifact. The method can also include determining an attribution for the new artifact.

Abstract: An attachment for use with a food processing system including a container body including a sidewall, a first end configured to be mounted to a food processing base, and a second end remote from said first end. The first end is open and the second end includes an end wall oriented transverse to the sidewall. A chamber is defined by said container body. A first agitating member is receivable at said first end and a second agitating member receivable at said second end. The second agitating member is extendable into said chamber from said second end.

Abstract: The present invention relates to treatment compositions containing polymer systems that provide stability and benefit agent deposition as well as methods of making and using same. Such treatment compositions may be used for example as through the wash and/or through the rinse fabric enhancers as well as unit dose treatment compositions.