Abstract: Data payloads from an external data storage system are processed in an observability pipeline system. In some aspects, the observability pipeline system defines a leader role and worker roles. The leader role generates a data discovery task based on configuration information for a data collection task. A worker role executes the data discovery task, which includes communicating with an external data storage system to identify a data payload that is stored on the external data storage system and contains event data that meet event filter criteria. The leader role generates data collection tasks based on the data payload. Worker roles execute the data collection tasks. Executing a data collection task includes communicating with the external data storage system to obtain a subset of filtered event data from the data payload; and streaming the subset of filtered event data to an observability pipeline process.

Abstract: A navigation system includes a plurality of information sources for use in determining a position estimate, including an inertial navigation system which determines an inertial-based position estimate, and a receiver which receives wireless signals from external transmitters. A first calculation unit repeatedly determines a first position estimate based on information derived from one or more of the information sources. A second calculation unit repeatedly determine a second position estimate based on information derived from one or more of the information sources. A selection unit repeatedly determines which of the first and second position estimates is more reliable, and selects one of these for output as an output position estimate. Over a period of time, first position estimate is determined based on a first set of information derived from one or more of the information sources, and the second position estimate is determined based on a second set of information.

Abstract: The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3?,5?-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.

Abstract: The present disclosure provides rolling release launching system that is operative to receive and retain a drone or other payload in a protected launcher. The launcher helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload is launched when a rotating door opens to expose the payload in a bay area. The rotating door may be parallel or concentric to a longitudinal axis of the body portion of the device. The payload may be launched using a biasing and fastening mechanism, which may include detachably coupling bracket, to induce an angular moment and releasing force on the payload during launch.

Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to magnetize the output coupler housing when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in an inner surface of a central opening in the output coupler housing and one or more engagement members located in the outer surface of the input shaft.

Abstract: The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.

Abstract: A universal wraparound knee brace includes a central body section having a concavely curved inside surface for engaging and extending vertically across the wearer's knee. A corresponding pair of first and second upper flaps extend from respective opposing vertical edges of the central body section and a pair of corresponding first and second lower flaps similarly extend from the opposite vertical edges of the central body section. The second upper and lower flaps carry respective interior D-rings. Each first flap is engaged with a respective interior D-ring attached to its corresponding second flap and is pulled through the D-ring in a reverse direction so that corresponding first and second flaps wrap around the wearer's leg above and below the knee. The corresponding first and second flaps are secured in place by complementary first and second hook and loop connectors. Each second flap also carries an elongate locking strap and a respective exterior D-ring attached at an inner end of the locking strap.

Abstract: Data payloads from an external data storage system are processed in an observability pipeline system. In some aspects, the observability pipeline system defines a leader role and worker roles. The leader role generates a data discovery task based on configuration information for a data collection task. A worker role executes the data discovery task, which includes communicating with an external data storage system to identify a data payload that is stored on the external data storage system and contains event data that meet event filter criteria. The leader role generates data collection tasks based on the data payload. Worker roles execute the data collection tasks. Executing a data collection task includes: communicating with the external data storage system to obtain a subset of filtered event data from the data payload; and streaming the subset of filtered event data to an observability pipeline process.

Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to magnetize the input shaft when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in the input shaft and one or more engagement members located in the inner surface of the central opening of the output coupler housing.

Abstract: The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.

Abstract: Systems and methods of the present disclosure relate to actuator assemblies for downhole tools. An actuator assembly comprises a ball screw; a ball nut disposed around the ball screw; a cam disposed around the ball nut; a rail disposed adjacent to the cam, the rail operable to stop rotation of the cam to extend the cam axially as the ball nut traverses the ball screw.

Abstract: A processing unit for automated preparation of biological samples included in specimen tubes is described herein. The processing unit includes a removable sample preparation component configured to receive specimen tubes, read identifiers associated with the biological samples contained in the specimen tubes, mix reagents included in the specimen tubes, and transfer the specimen tubes to at least one of a centrifuge or a storage compartment. The processing unit further includes a centrifuge loader for automatic loading and unloading of the specimen tubes onto a centrifuge. The automated centrifuge loader includes a magnetic brake that can stop the centrifuge rotor at a precise position to facilitate loading and unloading of a specimen tube. The centrifuge includes a swing bucket designed to pivot around an axis and slide vertically to enable moving the bucket to a position in which the swing bucket can engage with the port where the specimen tube resides.

Abstract: Embodiments provide techniques, including systems and methods, for identifying and matching requestors and providers. For example, embodiments can display an identification pattern that is unique for a matched requestor and provider to allow the providers and requestors to quickly, easily, and accurately validate one another's identities prior to a service being provided. In some embodiments, the identification element may be presented on a provider communication device to clearly display graphics associated with an identification element to all requestors in an area so that the requestors may easily identify a matched provider.

Abstract: Embodiments are disclosed for performing cache aware searching. In response to a search query, a first bucket and a second bucket in remote storage for processing the search query. A determination is made that a first file in the first bucket is present in a cache when the search query is received. In response to the search query, a search is performed using the first file based on the determination that the first file is present in the cache when the search query is received, and the search is performed using a second file from the second bucket once the second file is stored in the cache.

Abstract: A coupling system between the frame and the leg assembly of a workstation is described. The coupling system can be configured to selectively attach and detach the leg assembly from the frame. The leg assembly can include an adjustment mechanism. The adjustment mechanism can be configured to adjust the length of the leg. The leg assembly can include a leg coupling feature and the frame can have a frame coupling feature. The leg coupling feature can be configured to engage with the frame coupling feature, for instance to attach the leg to the frame. The workstation can include a latch configured to engage with the leg assembly. Engagement of the latch with the leg assembly can secure a position of the leg with respect to the frame.

Abstract: Disclosed herein are testing apparatuses for testing stresses in substrates. The testing apparatus includes a base, a first plate coupled to the base, the first plate being movable relative to the base along a first axis, a second plate coupled to the base, the second plate being movable relative to the base and relative to the first plate along a second axis that is perpendicular to the first axis, a first actuator operable to move the first plate along the first axis towards or away from the second plate, a second actuator operable to move the second plate along the second axis relative to the first plate, and a controller operatively connected to the first actuator and the second actuator operable to control movement of the first plate and the second plate.

Abstract: Load balancing processes are performed in an observability pipeline system comprising a plurality of computing resources. In some aspects, the observability pipeline system defines a leader role and worker roles. A plurality of computing jobs each include computing tasks associated with event data. The leader role dispatches the computing tasks to the worker roles according to a least in-flight task dispatch criteria, which includes iteratively: identifying an available worker role; identifying one or more incomplete computing jobs; selecting, from the one or more incomplete computing jobs, a computing job that has the least number of in-flight computing tasks currently being executed in the observability pipeline system; identifying a next computing task from the selected computing job; and dispatching the next computing task to the available worker role. The worker roles execute the computing tasks by applying an observability pipeline process to the event data associated with the respective computing task.