Abstract: The present invention relates to pyridazinones and related compounds having Formula I: and pharmaceutically acceptable salts thereof, which are inhibitors of PARP7 and are useful in the treatment of cancer.

Abstract: The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3?,5?-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.

Abstract: A cap includes an upper cap portion to enclose an opening of a bottle and hold a dosage of fluid, a lower cap portion to extend into the bottle and increase the dosage capacity of the cap, and a skirt configured to engage the exterior surface of the bottle to secure the cap to the bottle. The upper cap portion includes a top and a first sidewall having one or more sections that protrude radially away from other portions of first sidewall.

Abstract: The present technology provides a method of making a fluid catalytic cracking (FCC) catalyst, the method includes: in situ crystallizing Y-zeolite on a precursor microsphere to provide the FCC catalyst, wherein the in situ crystallizing includes: mixing the precursor microspheres with sodium silicate, a zeolite initiator (seeding zeolite crystals), and water to form an alkaline slurry; and heating the alkaline slurry to a temperature of about 38° C. (100° F.) to about 93° C. (200° F.) to obtain a zeolitic microsphere material; and wherein the FCC catalyst has a zeolite content of less than or equal to about 30 weight percent (wt.%). The unit cell size of the zeolite Y is 24.60 to 24.70 angstrom.

Abstract: Systems and methods are disclosed for processing and executing queries in a data intake and query system. The data intake and query system receives a query identifying a set of data to be processed and a manner of processing the set of data. The data intake and query system parses the query and uses a metadata catalog to dynamically identify configuration parameters of datasets and/or rules associated with the query. The identified configuration parameters are communicated to a query processing component of the data intake and query system for use in executing the query.

Abstract: A clamp assembly for securing a conduit to a strut, the clamp assembly includes a pair of brackets, each bracket having a head section and a tail section. The respective tail sections of the pair of brackets being configured to be received within the strut and the pair of brackets having respective apertures formed in the respective head sections thereof. A bolt has a shank that is configured to be received within the respective apertures of the pair of brackets. A nut has a bore therein, the bore is configured to receive the shank of the bolt. Each of the respective apertures includes a pair of opposite, rounded surfaces spaced from each other and connected by a pair of opposite, elongated surfaces.

Abstract: The present disclosure provides rolling release launching system that is operative to receive and retain a drone or other payload in a protected launcher. The launcher helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload is launched when a rotating door opens to expose the payload in a bay area. The rotating door may be parallel or concentric to a longitudinal axis of the body portion of the device. The payload may be launched using a biasing and fastening mechanism, which may include detachably coupling bracket, to induce an angular moment and releasing force on the payload during launch.

Abstract: An unmanned aerial vehicle (UAV) having wings stowed against a fuselage of the UAV in a first arrangement is disclosed. Methods and systems for deploying the wings into a second arrangement are disclosed. For example, after a launch of the UAV, the UAV monitors for at least one pre-set condition. The at least one pre-condition being a pre-condition associated with deploying wings of the UAV into the second arrangement. Upon detecting the at least one pre-set condition, the wings of the UAV are deployed into a second arrangement. Deploying the wings comprises activating, in response to detecting the at least one pre-set condition associated with the UAV, a gearbox configured to transition the wings from the first arrangement to the second arrangement. Roll control may be maintained throughout launch and deployment.

Abstract: Embodiments are disclosed for performing cache aware searching. In response to a search query, a first bucket and a second bucket in remote storage for processing the search query. A determination is made that a first file in the first bucket is present in a cache when the search query is received. In response to the search query, a search is performed using the first file based on the determination that the first file is present in the cache when the search query is received, and the search is performed using a second file from the second bucket once the second file is stored in the cache.

Abstract: A commodity dispenser system includes a terminal dispenser device with a container configured to contain a commodity. The terminal dispenser device includes a user-controlled dispenser for selectively dispensing the commodity from the container. The terminal dispenser device includes a sensor and a communication device, and the sensor is configured to detect an inventory condition of the commodity within the container. The system further includes a server configured to communicate with the communication device of the terminal dispenser device, receive a communication corresponding to the inventory condition detected, and initiate an order for a replenishing shipment of the commodity to the dispenser device based, at least partly, on the communication corresponding to the inventory condition detected.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: A modular crossover system includes one or more platforms, one or more platform guardrails attached to the platform, a plurality of towers supporting the one or more platforms, a plurality of stile assemblies attached to the platforms, or a combination of towers and stile assemblies. An optional fixed ladder may be attached to one of the platforms.

Abstract: A clamp assembly for securing a conduit to a strut, the clamp assembly includes a pair of brackets, each bracket having a head section and a tail section. The respective tail sections of the pair of brackets being configured to be received within the strut and the pair of brackets having respective apertures formed in the respective head sections thereof. A bolt has a shank that is configured to be received within the respective apertures of the pair of brackets. A nut has a bore therein, the bore is configured to receive the shank of the bolt. Each of the respective apertures includes a pair of opposite, rounded surfaces spaced from each other and connected by a pair of opposite, elongated surfaces.

Abstract: A container assembly includes a container having a neck, a cap removably coupled to the neck, and a spout disposed in the neck. The cap includes an upper cap portion and a skirt configured to be received on a rim of the neck. The skirt includes a skirt sidewall and a skirt flange extending radially between a sidewall of the upper cap and the skirt sidewall. The spout includes a central duct extending through an opening of the neck and defining a pouring passage in communication with an interior of the container. The spout includes an outer sidewall extending around the central duct. The spout includes a seal ring disposed on an upper end of the outer sidewall of the spout. A bottom surface of the skirt flange is inclined downward in a direction toward the neck of the container at an angle between about 1° and about 10°.

Abstract: A cap includes an upper cap portion to enclose an opening of a bottle and hold a dosage of fluid, a lower cap portion to extend into the bottle and increase the dosage capacity of the cap, and a skirt configured to engage the exterior surface of the bottle to secure the cap to the bottle. The upper cap portion includes a top and a first sidewall having one or more sections that protrude radially away from other portions of first sidewall.

Abstract: Certain aspects of the present disclosure provide techniques for generating a replacement sentence with the same or similar meaning but a different sentiment than an input sentence. The method generally includes receiving a request for a replacement sentence and iteratively determining a next word of the replacement sentence word-by-word based on an input sentence. Iteratively determining the next word generally includes evaluating a set of words of the input sentence using a language model configured to output candidate sentences and evaluating the candidate sentences using a sentiment model configured to output sentiment scores for the candidates sentences. Iteratively determining the next word further includes calculating convex combinations for the candidate sentences and selecting an ending word of one of the candidate sentences as the next word of the replacement sentence. The method further includes transmitting the replacement sentence in response to the request for the replacement sentence.

Abstract: A container assembly includes a container having a neck defining an opening into the container and a spout disposed in the neck of the container. The spout includes an outer sidewall defining an interior of the spout. The spout includes a flange projecting radially outward from the outer sidewall. The spout includes a plurality of spout teeth extending from a bottom surface of the flange and disposed around a perimeter of the outer sidewall. The neck of the container includes a plurality of neck teeth disposed along an interior surface of the neck and coupled with the spout teeth.

Abstract: The present disclosure is directed to a support block assembly including a strut and an overmolded support block. The strut may include a base, and the support block may include an anchor coupled to the strut. The anchor includes a tang with the support block overmolded on the tang with the tang extending into and encased within the support block forming a bond between the tang and the support block. In an embodiment, the base may define at least one opening. The support block is overmolded on the strut such that the support block extends through at least one opening to form the bond between the strut and the support block. The strut may include a lower side defining a dovetail-shaped groove with the support block overmolded on the strut and extending into the dovetail-shaped groove to form a bond between the strut and the support block.