Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to axially translate the output coupler housing from a de-coupled state to a coupled state when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in one of an outer surface of the input shaft or an inner surface of the central opening, and one or more engagement members located in the other of the inner surface of the central opening or the outer surface of the input shaft.

Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to magnetize the output coupler housing when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in an inner surface of a central opening in the output coupler housing and one or more engagement members located in the outer surface of the input shaft.

Abstract: Provided is a clutch assembly, a SSSV, and a method for operating an SSSV. The clutch assembly, in one aspect, includes an output coupler housing, an input shaft, and an electromagnet coupled to the input shaft. In at least one aspect, the electromagnet is configured to magnetize the input shaft when the electromagnet is energized. The clutch assembly, in one aspect, further includes one or more grooves located in the input shaft and one or more engagement members located in the inner surface of the central opening of the output coupler housing.

Abstract: A coupling system between the frame and the leg assembly of a workstation is described. The coupling system can be configured to selectively attach and detach the leg assembly from the frame. The leg assembly can include an adjustment mechanism. The adjustment mechanism can be configured to adjust the length of the leg. The leg assembly can include a leg coupling feature and the frame can have a frame coupling feature. The leg coupling feature can be configured to engage with the frame coupling feature, for instance to attach the leg to the frame. The workstation can include a latch configured to engage with the leg assembly. Engagement of the latch with the leg assembly can secure a position of the leg with respect to the frame.

Abstract: The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3?,5?-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.

Abstract: Systems and methods are described for generating and displaying user-specific garment renderings. For instance, a graphical user interface may be presented that includes an initial depiction of a user wearing a first garment in a first display position and a depiction of a next garment at a second display position. In response to a scroll or similar indication, a visual transition and updated user interface may result in presentation of an updated depiction of the user at the first display position, where the updated depiction shows the user wearing the next garment. The updated user interface may additionally include one or more further garments, separate from the user's body depiction, that may be interacted with to request a preview of those one or more additional garments on the depiction of the user within the user interface.

Abstract: A duplex visual tester for testing multiple fiber optic cable runs includes a housing having a first LED and a second LED in a duplex fiber connection. The first LED and the second LED are in electronic communication with a power source, a battery, an on/off switch, and a timer configured to pulse the first LED and the second LED. The first LED and the second LED are installed in the duplex fiber connection. The first LED has a first color, and the second LED has a second, different color, wherein the first color and the second color have the same luminosity. Preferably, the timer pulses the first LED and the second LED at between eight and ten Hz, such that the first color and second color can be seen in the fiber optic cable run.

Abstract: A processing unit for automated preparation of biological samples included in specimen tubes is described herein. The processing unit includes a removable sample preparation component configured to receive specimen tubes, read identifiers associated with the biological samples contained in the specimen tubes, mix reagents included in the specimen tubes, and transfer the specimen tubes to at least one of a centrifuge or a storage compartment. The processing unit further includes a centrifuge loader for automatic loading and unloading of the specimen tubes onto a centrifuge. The automated centrifuge loader includes a magnetic brake that can stop the centrifuge rotor at a precise position to facilitate loading and unloading of a specimen tube. The centrifuge includes a swing bucket designed to pivot around an axis and slide vertically to enable moving the bucket to a position in which the swing bucket can engage with the port where the specimen tube resides.

Abstract: Embodiments are disclosed for performing cache aware searching. In response to a search query, a first bucket and a second bucket in remote storage for processing the search query. A determination is made that a first file in the first bucket is present in a cache when the search query is received. In response to the search query, a search is performed using the first file based on the determination that the first file is present in the cache when the search query is received, and the search is performed using a second file from the second bucket once the second file is stored in the cache.

Abstract: The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.

Abstract: A coupling system between the frame and the leg assembly of a workstation is described. The coupling system can be configured to selectively attach and detach the leg assembly from the frame. The leg assembly can include an adjustment mechanism. The adjustment mechanism, can be configured to adjust the length of the leg. The leg assembly can include a leg coupling feature and the frame can have a frame coupling feature. The leg coupling feature can be configured to engage with the frame coupling feature, for instance to attach the leg to the frame. The workstation can include a latch configured to engage with the leg assembly. Engagement of the latch with the leg assembly can secure a position of the leg with respect to the frame.

Abstract: The present invention relates to solid forms of the poly(ADP-ribose) polymerase 14 (PARP14) inhibitor 7-((1-acetylpiperidin-4-yl)methoxy)-5-fluoro-2-(((tetrahydro-2H-pyran-4-yl)thio)methyl)quinazolin-4(3H)-one, including methods of preparation thereof, where the inhibitor is useful in the treatment of cancer and inflammatory diseases.

Abstract: The present invention relates to an oncolytic vaccinia virus and virus vectors for use in cancer therapy where in the virus comprises at least three vaccinia virus promoters which are positioned in the same orientation.

Abstract: The present disclosure provides a release launching system that is operative to receive and retain a drone or other payload in a protected launcher. The launcher helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload is launched when a force initially separates the payload from the launcher and exposes a force generating mechanism. The force generating mechanism may be within the body portion of the device and generate an additional force to assist in separating the payload from the launcher. The payload may be launched using a biasing and fastening mechanism, which may include detachably coupling bracket, to allow for the separation of the payload from the launcher.

Abstract: The present disclosure provides rolling release launching system that is operative to receive and retain a drone or other payload in a protected launcher. The launcher helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload is launched when a rotating door opens to expose the payload in a bay area. The rotating door may be parallel or concentric to a longitudinal axis of the body portion of the device. The payload may be launched using a biasing and fastening mechanism, which may include detachably coupling bracket, to induce an angular moment and releasing force on the payload during launch.

Abstract: Load balancing processes are performed in an observability pipeline system comprising a plurality of computing resources. In some aspects, the observability pipeline system defines a leader role and worker roles. A plurality of computing jobs each include computing tasks associated with event data. The leader role dispatches the computing tasks to the worker roles according to a least in-flight task dispatch criteria, which includes iteratively: identifying an available worker role; identifying one or more incomplete computing jobs; selecting, from the one or more incomplete computing jobs, a computing job that has the least number of in-flight computing tasks currently being executed in the observability pipeline system; identifying a next computing task from the selected computing job; and dispatching the next computing task to the available worker role. The worker roles execute the computing tasks by applying an observability pipeline process to the event data associated with the respective computing task.

Abstract: The present disclosure provides a payload deployment system that is operative to receive and retain a configurable payload. The payload deployment mechanism helps to reduce the drag of the payload and to protect the payload from environmental factors. The payload may be released using a hinge mechanism to ensure the payload does not contact the payload deployment mechanism when the payload is deployed. A vent may be utilized to equalize pressure between the external environment and a body portion of the payload deployment mechanism. The vent may generate an additional force to assist in separating the payload from the launcher.

Abstract: A sales person at a retail store which traditionally does not sell paint assists a consumer in selecting and purchasing a non-paint product and thereafter employs a computer terminal and display in conjunction with a website operated by a paint manufacturer to provide a paint color recommendation to the consumer. The sales person may thereafter respond to consumer selection of a particular paint color by employing an on-line electronic ordering tool to transmit a paint order to an order processing terminal located at a paint manufacturer facility. Thereafter, the paint manufacturer may proceed to process the order, perform tinting and shaking steps to formulate paint of the particular color, package the tinted paint, and cause the packaged paint to be shipped to the consumer.

Abstract: A color calibration system for color correction in an optical device using a database of target colors includes a physical target card. The physical target card includes at least three unique colored patches arranged in a predetermined pattern on the physical target card, identifying indicia, and alignment indicia. The color calibration system also includes an executable machine-readable software. The software is configured to read and assign a value to the colored patches. The software is further configured to read the identifying indicia and identify the physical target card, and to read the alignment indicia for identifying individual colored patches. The software is further configured to compare color values in the optical device to known factory color values, generate a target card profile, and convert native color space for use in subsequent images under the same lighting conditions.