Abstract: Example systems and methods of content sharing using notification within a social networking environment are presented. In one example, an indication is received from a first user device associated with a first user, the indication indicating that the first user device is available for supplying media content over a communication network. Social network information regarding the first user is retrieved. A second user of a second user device is identified based on an association between the first user and the second user according to the social network information. The second user device is notified of the availability of the first user device for the supplying of the media content.

Abstract: Example systems and methods of content sharing via multiple content distribution servers are presented. In one example, a media content stream is received at a first distribution server from a source device via a communication network. The received media content is transmitted from the first distribution server to a plurality of destination devices via the communication network. A traffic condition regarding the transmitting of the received media content stream is detected. An indication of the traffic condition is transmitted to a traffic management device. An instruction to assign at least one other distribution server to additional destination devices is received from the traffic management device in response to the indication of the traffic condition. In response to the instruction, the received media content stream is transmitted from the first distribution server to the at least one other distribution server for distribution to the additional destination devices.

Abstract: The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound under conditions where the VGSC and the p11 peptide are capable of forming a complex in the absence of the test compound; and measuring an activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC. Compounds identified in such screening methods are proposed for use in the treatment of VGSC-related conditions, for example in the treatment or prevention of pain. Also provided are methods of enhancing the functional expression of a voltage gated sodium channel (VGSC) in a cell comprising the step of increasing the level of p11 in the cell.

Abstract: A sensing device, apparatus and system, and method for operating the same are provided. The sensing apparatus includes a first module and a second module. The first module includes a controller, a transmitter and an array of sensor elements. The controller is capable of activating one or more sensor elements in the array independently of others in the array, in order to obtain a sensor output from the array at different times by using different sensor elements in said array. The transmitter is configured to transmit sensor data derived from the sensor output from the first module to a receiver of the second module. Each sensor element is a biological sensor for detecting the presence of the same analyte in the environment in which the sensor array is to be deployed.

Abstract: An intermediary node on a data communications network implements a flow control algorithm to control network congestion. The intermediary node receives messages destined for servers or other upstream nodes from clients or other downstream nodes and determines whether to forward the messages based on the flow control algorithm, which may be adaptive. The algorithm may consider explicit back-off messages received from upstream nodes, failure of upstream nodes to respond to messages forwarded by the intermediary node, and/or other criteria. When a back-off condition applies, the intermediary node refrains from forwarding messages it receives and sends back-off messages to nodes initiating the messages. Back-off messages may include a back-of time period and/or other back-off criteria.

Abstract: A method for determining the dosage regime of a drug suitable for use in the treatment of a neurological condition in a subject, which method comprises typing the SCN1A gene of the subject. The method may be used to determine the dosage regime of an anti-epileptic drug (AED) in a subject. A subject may be treated in accordance with the dosage regime determined using such a method.

Abstract: The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.

Abstract: The receptacle is shown for storing biologically contaminated items. The receptacle has a storage portion (901) and a closure portion (902) each fabricated from plastic card. The closure portion is placed in an open condition for receiving items or in a closed condition in which the receptacle is liquid-tight. A first sealing device (903) is provided for sealing the closure portion to allow transportation to a decontamination station.

Abstract: The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound under conditions where the VGSC and the p11 peptide are capable of forming a complex in the absence of the test compound: and measuring an activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC. Compounds identified in such screening methods are proposed for use in the treatment of VGSC-related conditions, for example in the treatment or prevention of pain. Also provided are methods of enhancing the functional expression of a voltage gated sodium channel (VGSC) in a cell comprising the step of increasing the level of p11 in the cell.

Abstract: The invention describes a bone anchor 76 comprising a head region 94 and supporting legs 78 and a method for soft tissue-bone grafting using the said bone anchor 76. A hole 84 is drilled through cortical bone 82 forming a socket 70 in a cancellous bone 90, and the bone anchor 76 is inserted therein thereby trapping ligaments 88a and 88b between the radially outermost portion of the anchor 76 and the inside surface of the socket 70. An optional expansion peg (not shown) is inserted into a hole 86 within the bone anchor 76, thereby causing the proximal ends of the legs 70 of the bone anchor 76 to expand radially causing the ligaments 88a and 88b to closely abut the cancellous bone 90 thereby encouraging the grafting process.

Abstract: The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.

Abstract: An apparatus and method for predicting potentially fatal arrhythmias up to twenty four hours in advance of the event by employing formulas indicating either too little or too much heart rate variability. A number of these formulas have both predetermined upper and lower limits, which if exceeded for a period of time are a predictor of a potentially fatal arrhythmia. When a patient's ALARM condition is predicted, whether the patient is indoors or outdoors, conscious or unconscious, a redundant protocol is utilized to relay that ALARM condition to a central monitoring station. The central monitoring station informs the patient's doctor, and then uses what ever means are available to transport the patient to the nearest emergency room for treatment. An apparatus and method for pacing the heart in a natural way, once a potentially fatal arrhythmia has been predicted is also disclosed.

Abstract: The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.

Abstract: An intermediary node on a data communications network implements a flow control algorithm to control network congestion. The intermediary node receives messages destined for servers or other upstream nodes from clients or other downstream nodes and determines whether to forward the messages based on the flow control algorithm, which may be adaptive. The algorithm may consider explicit back-off messages received from upstream nodes, failure of upstream nodes to respond to messages forwarded by the intermediary node, and/or other criteria. When a back-off condition applies, the intermediary node refrains from forwarding messages it receives and sends back-off messages to nodes initiating the messages. Back-off messages may include a back-of time period and/or other back-off criteria.

Abstract: A microprocessor (300) with a date and time clock gathers time interval data (80, 86). The duration of the time intervals in an electrocardiogram, or pulses are recorded. Stress data accumulated for the user are down loaded to a PC (301). The battery power pack (303) supplies electricity to operate the components (80-318). The user's stress status is displayed on a liquid crystal diode (302), and the voice microprocessor (318) broadcasts from a microspeaker CPR instructions. If the battery (303) has less than a 20% charge, a buzzer (304) notifies the user.

Abstract: The duration of Time Intervals, preferably 101, in an electrocardiogram, or pulses are recorded. The Mode, ?Mo!, or the duration most often recorded, the Median, ?M!, of all durations recorded, the Amplitude of the Mode, ?AMo!, expressed as a percentage of the most frequently recorded Modes, and the difference in duration between the longest and the shortest duration recorded, Delta X, ?DX!, are determined and consolidated into one or more Cluster Modes, ?CMo!, comprised of three Modes each, establishes a user's baseline. If any of the 9 formulas derived from these functions differs by a predetermined percentage and time duration from the user's baseline, then the user's stress has reached an ALARM level. The apparatus make take the form of a chest strap on which are mounted electrocardiogram electrodes, which transmits Time Intervals to a wrist watch like device where the calculations are performed and the results displayed.